A5026438319- Photonic Crystal and Fiber Optics
- Advanced Fiber Laser Technologies
- Optical Network Technologies
- Advanced Fiber Optic Sensors
- Photonic and Optical Devices
- Spectroscopy Techniques in Biomedical and Chemical Research
- Laser-Matter Interactions and Applications
- Solid State Laser Technologies
- Glass properties and applications
- Quantum optics and atomic interactions
- Optical Coherence Tomography Applications
- Metabolomics and Mass Spectrometry Studies
- Nonlinear Optical Materials Studies
- Photoacoustic and Ultrasonic Imaging
- Luminescence Properties of Advanced Materials
- Advanced Photonic Communication Systems
- Photorefractive and Nonlinear Optics
- Atomic and Subatomic Physics Research
- Semiconductor Lasers and Optical Devices
- Bee Products Chemical Analysis
- ATP Synthase and ATPases Research
- Random lasers and scattering media
- Calcium signaling and nucleotide metabolism
- Genetics, Aging, and Longevity in Model Organisms
- Phase-change materials and chalcogenides
Janelia Research Campus
2025
Howard Hughes Medical Institute
2025
Baylor College of Medicine
2020-2022
The University of Tokyo
2016-2020
Tokyo University of Information Sciences
2017-2020
Toyota Technological Institute
2013-2017
Heinz Optical Engineering (United States)
2015
National Institute of Technology, Toyota College
2013
Shanghai Jiao Tong University
2008-2011
Combining the strength of flow cytometry with fluorescence imaging and digital image analysis, is a powerful tool in diverse fields including cancer biology, immunology, drug discovery, microbiology, metabolic engineering. It enables measurements statistical analyses chemical, structural, morphological phenotypes numerous living cells to provide systematic insights into biological processes. However, its utility constrained by requirement fluorescent labeling for phenotyping. Here we present...
The advent of image-activated cell sorting and imaging-based picking has advanced our knowledge exploitation biological systems in the last decade. Unfortunately, they generally rely on fluorescent labeling for cellular phenotyping, an indirect measure molecular landscape cell, which critical limitations. Here we demonstrate Raman by directly probing chemically specific intracellular vibrations via ultrafast multicolor stimulated scattering (SRS) microscopy phenotyping. Specifically,...
We demonstrate the supercontinuum (SC) generation in a suspended-core As(2)S(3) chalcogenide microstructured optical fiber (MOF). The variation of SC is investigated by changing length, pump peak power and wavelength. In case long fibers (20 40 cm), ranges are discontinuous stop at wavelengths shorter than 3500 nm, due to absorption fiber. short (1.3 2.4 continuous can extend longer 4 μm. broadening observed when increases from 0.24 1.32 kW 2500 nm. range with wavelength 2200 2600...
An As2S3 fiber-based supercontinuum source that covers 3500 nm, extending from near visible to the midinfrared, is successfully reported by using a 200-fs-pulsed pump with nJ-level energy at 2.5 μm. The main features of our are two-fold. On one hand, low-loss microstructured optical fiber has been fabricated, typical attenuation below 2 dB/m in 1–4 μm wavelength range. other 20-mm-long sample sufficient enable spectral broadening, spreading 0.6 4.1 40 dB dynamic
We demonstrate the direct generation of 55 fs pulses from an all-fiber Erbium-doped ring laser oscillator using nonlinear polarization rotation mode-locking. The average output power is 56.4 mW but limited by available pump 330 mW. linear chirped pulse duration after recompression standard single-mode fiber. show to resist optical wave breaking with a smooth spectrum without any side lobe and cw-breakthrough. This exhibits relatively high transfer efficiency 17% single energy reaches 1.5 nJ.
A hybrid four-hole AsSe2-As2S5 microstructured optical fiber (MOF) is fabricated by the rod-in-tube drawing technique. The core made of AsSe2 glass and cladding As2S5 glass. material refractive indices are ∼2.832 ∼2.219 at wavelength ∼2.8 μm, respectively. calculated zero-dispersion MOF 2.759 μm. Soliton self-frequency shift with a soliton central from 2.986 to 3.419 μm observed when pumped an parametric oscillator pump At same time blue-shift dispersive wave emitted soliton.
We demonstrate the broadband cascaded four-wave mixing (FWM) and supercontinuum (SC) generation in a tellurite MOF which is made from 76.5TeO(2)-6ZnO-11.5Li(2)O-6Bi(2)O(3) (TZLB, mol%) glass. By using 2-μm picosecond laser with center wavelength of ~1958 nm as pump source, FWM frequency separation ~1.1 THz obtained. The bandwidth comb spans range ~630 ~1620 to 2250 at average power ~125 mW. With increasing ~800 mW, mid-infrared SC spectrum ~900 3900 observed. Changing source femtosecond...
A hybrid four-hole AsSe2-As2S5 microstructured optical fiber (MOF) with a large refractive index difference is fabricated by the rod-in-tube drawing technique. The core and cladding are made from AsSe2 glass As2S5 glass, respectively. propagation loss ~1.8 dB/m nonlinear coefficient ~2.03 × 10(4) km(-1)W(-1) at 2000 nm. Raman scattering observed in normal dispersion regime when pumped 2 μm mode-locked picosecond laser. Additionally, soliton generated anomalous an parametric oscillator (OPO)...
novel AsSe(2)-As(2)S(5) hybrid MOF (HMOF) is designed and fabricated by the rod-in-tube drawing technique. The core made from AsSe2 glass cladding As(2)S(5) glass. loss ~1.2 dB/m at ~3000 nm. Zero dispersion wavelength (ZDW) of HMOF ~3380 Supercontinuum (SC) generation in a 2 cm-long investigated with pump wavelengths ~3062, 3241 3389 nm tunable optical parametric oscillator (OPO) system. Broadband midinfrared (MIR) SC spectrum ~1256 to 5400 obtained peak power ~1337 kW ~3389
Soliton self-frequency shift (SSFS) and third-harmonic generation (THG) are observed in a four-hole As2S5 chalcogenide microstructured optical fiber (MOF). The MOF is tapered to offer an ideal environment for SSFS. After tapering, the zero-dispersion wavelength (ZDW) shifts from 2.02 1.61 μm, rate of SSFS can be enhanced by increasing energy density pulse. By varying average input power 220 340 mW, soliton central 2.206 2.600 μm mid-infrared segment, THG at 632 nm untapered segment.
An ultra-broadband supercontinuum (SC) covering 0.2–8.0 µm which is more than 5 octaves, demonstrated in a piece of fluoride glass. The 20 dB bandwidth spans from 0.39 to 7.4 µm. filaments, bright conic visible emission, and interference fringe pattern are observed. glass thickness, optical path, pump conditions optimized enable the SC cover entire transmission range glass, includes whole functional group region chemical bands groups. conversion efficiency confirmed be stable.
A simple all-solid tellurite microstructured optical fiber which has only one layer of high-index rods in the cladding is proposed and fabricated paper. The core with low index are made from TeO(2)-ZnO-Na(2)O-La(2)O(3) glass, TeO(2)-Li(2)O-WO(3)-MoO(3)-Nb(2)O(5) glass. guiding regime this can be explained by ARROW model. support near- mid-infrared light transmitting within transmission bands while silica cannot. When pump outside bands, will transmit six TLWMN rods.
The endolysosomal system plays a crucial role in maintaining cellular homeostasis and promoting organism fitness. pH of its acidic compartments is parameter for proper function, it dynamically influenced by both intracellular environmental factors. Here, we present method based on fluorescence lifetime imaging microscopy (FLIM) quantitatively analyzing the profiles diverse types primary mammalian cells live Caenorhabditis elegans. This FLIM-based exhibits high sensitivity resolving subtle...
The parametric amplification gain and bandwidth in highly nonlinear tellurite hybrid microstructured optical fiber (HMOF) are simulated based on four wave mixing process. core cladding materials made of TeO(2)–Li(2)O–WO(3)–MoO(3)–Nb(2)O(5) TeO(2)–ZnO–Na(2)O–P(2)O(5) glass, respectively. has zero-dispersion wavelengths the chromatic dispersion is flattened near zerodispersion wavelengths. A broad as wide 1200 nm from 1290 to 2490 can be realized infrared window by using a HMOF short 25 cm.
Energy transfer between Tm3+ and Tb3+ dependent on the power density of pump laser was investigated in NaYF4: Tb3+,Tm3+,Yb3+ microcrystals. Under excitation a 976-nm near-infrared at various densities, Tb3+-Tm3+-Yb3+ doped samples exhibited intense visible emissions with tunable color green blue. The ratio blue emission were determined by energy Tb3+. When low, process from (3F4) to (7F0) occurred efficiently. Upconversion processes inhibited, only observed. increased, 3F4 (Tm3+) 7F0 level...
A chalcogenide-tellurite hybrid optical fiber with a step-index structure is fabricated by the rod-in-tube drawing technique. The core made of 15Ge-3Ga-12Sb-70S (mol. %) glass, and cladding 78TeO₂-5ZnO-12Li₂O-5Bi₂O₃ glass. refractive index difference Δn=0.24. Tunable third-harmonic generation from 568 to 869 nm observed when pumped an parametric oscillator pump wavelength changing 1700 2600 nm.
The supercontinuum generation has been obtained in short conventional dispersion-shifted fiber using the femtosecond pulses from a passively mode-locked erbium-doped laser. In experiment, spectrum of >300 nm observed by injecting 70-fs into several-meter fiber. simulation evolution shows that spectral broadening arises soliton dynamics when pumping anomalous group velocity dispersion regime
We demonstrate a highly efficient, stable, and tunable dispersive wave (DW) emitted by the soliton in tellurite microstructured optical fiber. The dependence of generated DW properties on average pump power is experimentally investigated. By using 80-MHz pulse from an parametric oscillator as source, ~1626 to 1685 nm obtained with changing ~250 440 mW at wavelength ~1760 nm. conversion efficiency over ~65%. full width half maximum (FWHM) center 1626 ~90 fs, which was measured intensity...
A high numerical aperture (NA) step-index fiber with As2Se3 core and As2S5 cladding was fabricated for deep mid-infrared (MIR) transmission over 10 µm. MIR supercontinuum generation covering the wavelength from 3 to µm successfully demonstrated in this using a pulsed laser source µJ-level energy output around 7 4-cm-long sample is sufficient enable spectral broadening spreading 20 dB dynamic range.
Chalcogenide (As(2)S(3)) nanofibers as narrow 200 nm in diameter are drawn by the fiber pulling method, successfully embedded SU8 polymer, and form on-chip waveguides high-Q microknot resonators (Q = 3.9 × 10(4)) with smooth cleaved end faces. Resonance tuning of is realized localized laser irradiation. Strong supercontinuum generation a bandwidth 500 achieved 7-cm-long chalcogenide waveguide. Our result provides method for development compact, high-optical-quality, robust photonic devices.
We report on the multiple midinfrared soliton generation based a birefringent tellurite microstructured optical fiber pumped in deep anomalous dispersion regime at 2 μm. The wavelengths of solitons can be continuously shifted to longer wavelength region by Raman-induced frequency shift effect. central first polarized parallel fast axis tuned as wide 680 nm from 2050 2730 adjusting pump power. After polarization is operated 45° axis, two pairs generated trapping
A chalcogenide-tellurite hybrid microstructured optical fiber is designed and fabricated by the rod-in-tube drawing technique. The core made of chalcogenide glass with a composition 15Ge-3Ga-12Sb-70S (atm%, GGSS) cladding tellurite 78TeO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> -5ZnO-12Li O-5Bi O xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> (mol%, TZLB). loss ~1.1 dB/m at ~2.0 μm. Zero dispersion wavelength HMOF shifted down...