A5055650765- Mosquito-borne diseases and control
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Vectors
- Antibiotic Resistance in Bacteria
- Insect symbiosis and bacterial influences
- SARS-CoV-2 detection and testing
- Cancer therapeutics and mechanisms
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Malaria Research and Control
- Respiratory viral infections research
- Antibiotics Pharmacokinetics and Efficacy
- Influenza Virus Research Studies
- Vector-Borne Animal Diseases
- Trypanosoma species research and implications
- Virology and Viral Diseases
- Antimicrobial Resistance in Staphylococcus
- Animal Disease Management and Epidemiology
- Genetics and Neurodevelopmental Disorders
- Synthesis of heterocyclic compounds
- Vibrio bacteria research studies
- Quinazolinone synthesis and applications
- Viral Infections and Outbreaks Research
- Rabies epidemiology and control
- vaccines and immunoinformatics approaches
Universidad del Rosario
2019-2025
University of Boyaca
2019-2025
Universidade do Estado da Bahia
2024-2025
Dongguan People’s Hospital
2023
Icahn School of Medicine at Mount Sinai
2023
Universidad Cooperativa de Colombia
2023
IQE (United Kingdom)
2023
Fundación Instituto de Inmunología de Colombia
2019-2020
Adamas Pharmaceuticals (United States)
2017
Fraxa Research Foundation
2014
Abstract The high numbers of COVID-19 cases and deaths in Brazil have made Latin America an epicentre the pandemic. SARS-CoV-2 established sustained transmission early pandemic, but important gaps remain our understanding virus dynamics at a national scale. We use 17,135 near-complete genomes sampled from 27 Brazilian states bordering country Paraguay. From March to November 2020, we detected co-circulation multiple viral lineages that were linked importations (predominantly Europe). After...
ABSTRACT ACHN-490 is a neoglycoside, or “next-generation” aminoglycoside (AG), that has been identified as potentially useful agent to combat drug-resistant bacteria emerging in hospitals and health care facilities around the world. A focused medicinal chemistry campaign produced collection of over 400 sisomicin analogs from which was selected. We tested against two panels Gram-negative Gram-positive pathogens, many harbored AG resistance mechanisms. Unlike legacy AGs, active strains...
ABSTRACT Avibactam, a non-β-lactam β-lactamase inhibitor with activity against extended-spectrum β-lactamases (ESBLs), KPC, AmpC, and some OXA enzymes, extends the antibacterial of ceftazidime most ceftazidime-resistant organisms producing these enzymes. In this study, bactericidal ceftazidime-avibactam 18 Pseudomonas aeruginosa isolates 15 Enterobacteriaceae isolates, including wild-type ESBL, and/or AmpC producers, was evaluated. Ceftazidime-avibactam MICs (0.016 to 32 μg/ml) were lower...
Abstract Summary Oropouche virus (OROV), initially detected in Trinidad and Tobago 1955, has been historically confined to the Amazon Basin. However, since late 2022, OROV reported northern Brazil as well urban centers Bolivia, Colombia, Cuba, Peru. Herein, we describe generation of 133 new publicly available full genomes. We show how evolved via genome component reassortment it rapidly spread across multiple states Brazil, causing largest outbreak ever recorded outside basin, including...
Oropouche virus (OROV), first detected in Trinidad and Tobago 1955, was historically confined to the Brazilian Amazon Basin. However, since late 2022, an increasing number of OROV cases have been reported across various regions ofBrazilas well as urban centers Bolivia, Ecuador, Guyana, Colombia, Cuba, Panama Peru. In collaboration with Central Public Health Laboratories Brazil, we integrated epidemiological metadata genomic analyses from recent cases, generating 133 whole-genome sequences...
Abstract Comparative studies of the microbiota in whole-body mosquitoes from natural populations and laboratory-reared specimens are scarce, particularly tropical countries like Colombia, where understanding microbial patterns is critical for effective disease control vector management. This study examines bacterial Aedes aegypti by comparing field-collected 3 Colombian regions (Southern Amazon, Central Andean region, Northern Caribbean coast) with laboratory strains (Rockefeller, Otanche,...
Abstract The appearance of new variants SARS‐CoV‐2 has recently challenged public health authorities with respect to tracking transmission and mitigating the impact in evolving pandemic across countries. B.1.525 is considered a variant under investigation since it carries specific genetic signatures present P.1, B.1.1.7, B.1.351. Here we report genomic evidence first likely imported case variant, isolated traveler returning from Nigeria.
Fosfomycin is a broad-spectrum cell wall active agent that inhibits the MurA enzyme involved in peptidoglycan synthesis and FDA-approved for treatment of uncomplicated urinary tract infections (UTIs) caused by Escherichia coli Enterococcus faecalis women. Data regarding susceptibility recent UTI isolates to fosfomycin are limited. This study compared 658 US with ciprofloxacin, levofloxacin, nitrofurantoin, trimethoprim/sulfamethoxazole (SXT). Isolates included E. (n = 257), Klebsiella spp....
Conformationally constrained tetracyclic fluoroquinolones (FQs) were synthesized and profiled for their microbiological spectrum. The installation of a seven-membered ring between the pyrrolidine substituents C8 position on FQ core scaffold resulted in remarkable enhancement potency toward both Gram-positive Gram-negative bacteria. Focused optimization composition, stereochemistry, amine placement led to discovery two lead compounds that selected further progression.
Abstract Influenza A and B viruses represent significant global health threats, contributing substantially to morbidity mortality rates. However, a comprehensive understanding of the molecular epidemiology these in Brazil, continental-size country crucial hub for entry, circulation, dissemination influenza within South America, still needs be improved. This study addresses this gap by consolidating data samples across all Brazilian macroregions, as part Center Viral Surveillance Serological...
Tracking the spread of SARS-CoV-2 variants concern is crucial to inform public health efforts and control ongoing pandemic. Here, we report genetic evidence for circulation P.1 variant in Northeast Brazil. We advocate increased active surveillance ensure adequate this throughout country.
There is limited and controverting evidence looking at possible associations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA copies patient variables in large cohorts symptomatic asymptomatic patients.We studied 2275 patients from Colombia with disease 2019 (COVID-19) analyzed the between RT-PCR cycle threshold (Ct) value gender, age, comorbidities, symptomatology, severity.15.4 % samples (n = 428) reported least one comorbidity. were 2011 cases (72.4 %), being most...
Abstract Tracking the spread of SARS-CoV-2 variants concern is crucial to inform public health efforts and control ongoing pandemic. Here, we report genetic evidence for circulation P.1 variant in Northeast Brazil. We advocate increased active surveillance ensure adequate this throughout country. Article Summary Line Active genomic SARS- CoV-2 suspected cases from recent travelers reveals P1 Bahia state,
A comprehensive understanding of the virome in mosquito vectors is crucial for assessing potential transmission viral agents, designing effective vector control strategies, and advancing our knowledge insect-specific viruses (ISVs). In this study, we utilized Oxford Nanopore Technologies metagenomics to characterize
Abstract Bats are known reservoirs for a wide range of pathogenic microorganisms, including viruses, bacteria, fungi, helminths, and protozoa, which can be transmitted infect other zoonotic organisms. Various studies have utilised next-generation sequencing (NGS) to describe the pathogens associated with bats. Although most characterised microbial communities in specific body fluids, few analysed composition diversity these across different fluids at individual level. In this study, we...
Here, we report the first draft genome sequence of Lactobacillus kunkeei strain MP2, isolated from a Chilean honeybee gut. The sequenced has total size 1.58 Mb distributed into 44 contigs and 1,356 protein-coding sequences.