Nasreen Mahomed
A5076600605- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Infectious Diseases and Tuberculosis
- Diagnosis and treatment of tuberculosis
- Pleural and Pulmonary Diseases
- Tuberculosis Research and Epidemiology
- Congenital Diaphragmatic Hernia Studies
- Ultrasound in Clinical Applications
- Emergency and Acute Care Studies
- Gastrointestinal disorders and treatments
- COVID-19 diagnosis using AI
- Urological Disorders and Treatments
- Lung Cancer Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Radiology practices and education
- Orthopedic Infections and Treatments
- Neonatal and fetal brain pathology
- Pneumocystis jirovecii pneumonia detection and treatment
- Craniofacial Disorders and Treatments
- Advanced X-ray and CT Imaging
- Radiation Dose and Imaging
- Genetic and Kidney Cyst Diseases
- Neurofibromatosis and Schwannoma Cases
- Aortic Disease and Treatment Approaches
- Chromatin Remodeling and Cancer
University of the Witwatersrand
2012-2025
Respiratory and Meningeal Pathogens Research Unit
2017
Medical Research Council
2017
Johannesburg Hospital
2017
Chris Hani Baragwanath Hospital
2012-2015
University of Cape Town
2014
University Health Network
2008
Toronto Western Hospital
2008
Helen Joseph Hospital
2007
Pneumonia is the leading cause of death among children younger than 5 years. In this study, we estimated causes pneumonia in young African and Asian children, using novel analytical methods applied to clinical microbiological findings.
Previous studies suggested an association between upper airway pneumococcal colonization density and pneumonia, but data in children are limited. Using from the Pneumonia Etiology Research for Child Health (PERCH) study, we assessed this potential association. PERCH is a case-control study 7 countries: Bangladesh, The Gambia, Kenya, Mali, South Africa, Thailand, Zambia. Cases were aged 1–59 months hospitalized with World Organization–defined severe or very pneumonia. Controls randomly...
The etiologic inference of identifying a pathogen in the upper respiratory tract (URT) children with pneumonia is unclear. To determine if viral load could provide evidence causality pneumonia, we compared URT World Health Organization-defined severe and very age-matched community controls.In 9 developing country sites, nasopharyngeal/oropharyngeal swabs from without were tested using quantitative real-time polymerase chain reaction for 17 viruses. association case status was evaluated...
Chest radiographs (CXRs) are a valuable diagnostic tool in epidemiologic studies of pneumonia. The World Health Organization (WHO) methodology for the interpretation pediatric CXRs has not been evaluated beyond its intended application as an endpoint measure bacterial vaccine trials.The Pneumonia Etiology Research Child (PERCH) study enrolled children aged 1-59 months hospitalized with WHO-defined severe and very pneumonia from 7 low- middle-income countries. An process categorized each CXR...
Chest radiographs (CXRs) are frequently used to assess pneumonia cases. Variations in CXR appearances between epidemiological settings and their correlation with clinical signs not well documented.The Pneumonia Etiology Research for Child Health project enrolled 4232 cases of hospitalized World Organization (WHO)-defined severe very from 9 sites 7 countries (Bangladesh, the Gambia, Kenya, Mali, South Africa, Thailand, Zambia). At admission, each case underwent a standardized assessment risk...
There is limited information on the association between colonization density of upper respiratory tract colonizers and pathogen-specific pneumonia. We assessed this for Haemophilus influenzae, Moraxella catarrhalis, Staphylococcus aureus, Pneumocystis jirovecii.In 7 low- middle-income countries, nasopharyngeal/oropharyngeal swabs from children with severe pneumonia age-frequency matched community controls were tested using quantitative polymerase chain reaction (PCR). Differences in median...
Induced sputum (IS) may provide diagnostic information about the etiology of pneumonia. The safety this procedure across a heterogeneous population with severe pneumonia in low- and middle-income countries has not been described. IS specimens were obtained as part 7-country study very hospitalized children <5 years age. Rigorous clinical monitoring was done before, during, after to record oxygen requirement, saturation, respiratory rate, consciousness level, other evidence deterioration....
It is standard practice for laboratories to assess the cellular quality of expectorated sputum specimens check that they originated from lower respiratory tract. The presence low numbers squamous epithelial cells (SECs) and high polymorphonuclear (PMN) are regarded as indicative a tract specimen. However, these ratings have never been evaluated induced children with suspected pneumonia. We Gram stain smears cultures hospitalized aged 1–59 months enrolled in large study community-acquired...
Sputum examination can be useful in diagnosing the cause of pneumonia adults but is less well established children. We sought to assess diagnostic utility polymerase chain reaction (PCR) for detection respiratory viruses and bacteria induced sputum (IS) specimens from children hospitalized with severe or very pneumonia.Among aged 1-59 months, we compared organism by multiplex PCR IS nasopharyngeal/oropharyngeal (NP/OP) specimens. To whether presence density was associated chest radiographic...
Abstract Background: Since COVID-19 became a global pandemic in 2020, Computed tomography (CT) chest and CT pulmonary angiography (CTPA) have been identified to be highly sensitive for identifying features complications. Objectives: The study aimed describe the typical imaging findings on prevalence of embolism patients across three infection periods, each with dominant virus strain, Beta, Delta, Omicron variants. Methods: A retrospective review CTPA images adult imaged from October 2020...
The Greulich and Pyle (GP) method is the most commonly used manual bone age assessment but it associated with interrater variability. BoneXpert fully automated, eliminates variability has been validated for use in various populations. To compare GP automated performing of children paediatric endocrinology diagnoses. Three readers performed assessment, software on 260 left hand-wrist radiographs. Images where average three (Manual BA) deviated from BA by > 1.5 years, were re-read an external...
Detection of pneumococcus by lytA polymerase chain reaction (PCR) in blood had poor diagnostic accuracy for diagnosing pneumococcal pneumonia children 9 African and Asian sites. We assessed the value quantification pneumonia.The Pneumonia Etiology Research Child Health (PERCH) case-control study tested whole PCR aged 1-59 months hospitalized with signs age-frequency matched community controls. The distribution load among PCR-positive participants was compared between microbiologically...
SUMMARY Background Paradoxical tuberculosis (TB)‐associated Immune Reconstitution Inflammatory Syndrome (IRIS) is a common complication of combination antiretroviral treatment (cART) initiation in adults residing resource‐limited regions. Little known about the burden and presentation TB‐IRIS children initiating cART while receiving TB treatment. Methods Prospective cohort study South African on Children were assessed clinically by chest x‐ray before starting at 2, 4, 6, 12 weeks post...
Variations and abnormalities of skull appearance shape are generally related to a primary maldevelopment the brain. The copper-beaten is typically associated with craniosynostosis, where premature fusion cranial bone sutures results in growing brain exerting pressure on malleable cranium, producing pattern known as appearance.
Diagnostic reference levels (DRLs) are a crucial element of auditing radiation doses in paediatric computed tomography (CT). Currently, there no national CT DRLs South Africa.The aim this article was to establish local for examinations at two academic hospitals and compare output with established the developed developing world.Computed Tomography Dose Indexvolume (CTDIvol) dose length product (DLP) values were collected from performed university patients aged 0-15 years, during 01 November...
Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in paediatric age group, ranking fourth frequency after central nervous system tumours, neuroblastomas and nephroblastomas. Embryonal RMS of biliary tree considered a rare entity, with clinical presentation being that obstructive jaundice. We present case 4-year-old boy who presented hepatomegaly Biochemically, there was evidence elevated ductal enzymes conjugated hyperbilirubinaemia. The magnetic resonance imaging (MRI) features...