A5023681774- Pancreatic and Hepatic Oncology Research
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Advanced biosensing and bioanalysis techniques
- NF-κB Signaling Pathways
- Pancreatitis Pathology and Treatment
- Endoplasmic Reticulum Stress and Disease
- Dendrimers and Hyperbranched Polymers
- Esophageal and GI Pathology
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Cancer Genomics and Diagnostics
- Cell death mechanisms and regulation
- Renal and related cancers
- Gastrointestinal disorders and treatments
- biodegradable polymer synthesis and properties
- Fibroblast Growth Factor Research
- Inflammatory mediators and NSAID effects
- Wnt/β-catenin signaling in development and cancer
- TGF-β signaling in diseases
- Epigenetics and DNA Methylation
- Blood properties and coagulation
- Gastrointestinal Bleeding Diagnosis and Treatment
- Ubiquitin and proteasome pathways
Shanghai Jiao Tong University
2014-2020
Ruijin Hospital
2016-2020
Second Military Medical University
2018
The University of Texas MD Anderson Cancer Center
2009-2011
Children's Cancer Center
2010
Baylor College of Medicine
2010
Fudan University
1999
Epithelial tumor cells transit to a mesenchymal state in response extracellular cues, process known as epithelial-to-mesenchymal transition (EMT). The precise nature of these cues has not been fully defined, an important issue given that EMT is early event metastasis. Here, we have found population metastasis-prone mouse lung adenocarcinoma expresses Notch and ligands the ligand Jagged2 promotes Mechanistically, was promote metastasis by increasing expression GATA-binding (Gata) factors,...
Abstract The microRNA-200 (miR-200) family is part of a gene expression signature that predicts poor prognosis in lung cancer patients. In mouse model K-ras/p53-mutant adenocarcinoma, miR-200 levels are suppressed metastasis-prone tumor cells, and forced inhibits growth metastasis, but the target genes drive tumorigenesis have not been fully elucidated. Here, we scanned genome for putative binding sites found them 3′-untranslated region (3′-UTR) 35 amplified human cancer. Mining database...
Research Article27 March 2017Open Access Transparent process Niacin ameliorates ulcerative colitis via prostaglandin D2-mediated D prostanoid receptor 1 activation Juanjuan Li Department of Gastroenterology, Ruijin Hospital affiliated to Shanghai Jiao Tong University School Medicine, Shanghai, China Key Laboratory Food Safety Research, Institute for Nutritional Sciences, Institutes Biological Chinese Academy Search more papers by this author Deping Kong Qi Wang Wei Wu Yanping Tang Tingting...
// Qi Wang 1, * , Juanjuan Li Wei Wu Ruizhe Shen He Jiang 1 Yuting Qian Yanping Tang Tingting Bai Sheng Lumin Yi Zang Ji Zhang 2 Lifu Department of Gastroenterology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School Medicine, 200025, China State Key Laboratory Medical Genomics and Sino-French Research Center for Life Sciences Genomics, Authors share co-first authorship Correspondence to: Wang, e-mail: lifuwang@sjtu.edu.cn Keywords: Pitx2, Smad4, PPP2R2A, pancreatic cancer,...
Spindle and kinetochore-associated protein 1(SKA1), originally identified as a essential for proper chromosome segregation, has been recently linked to multiple malignancies. This study aimed explore the biological, clinical role molecular mechanism of SKA1 in pancreatic carcinogenesis.SKA1 expression was detected 145 ductal adenocarcinoma (PDAC) specimens by immunohistochemistry. Biological behaviour assays were used determine PDAC progression vitro vivo. Using isobaric tags relative...
Wnt1 inducible signaling pathway protein-1 (WISP1) may play an important role in promoting carcinogenesis. However, the biological function and underlying mechanism of WISP1 pancreatic carcinogenesis still remains enigmatic. In this study, immunochemistry staining showed that protein levels were more significantly upregulated ductal adenocarcinoma (PDAC) tissues with Tp53 mutation than PDAC wild-type. addition, a significant correlation was observed between increased malignant phenotype...
Cationic polymers readily degradable in response to cellular environment are especially favored as easy-formulating materials pack siRNA into a nanoparticle and release the cargo cytoplasm time. In addition efficiency of cytosomal release, degradation products should best be free safety concerns, typical challenge for cationic polymers. To satisfy two criteria, we report new polymer, polyspermine imine, named PSP-Imine, which is formed by condensing endogenous molecules, spermine glyoxal,...
The EI24 autophagy-associated transmembrane protein is frequently associated with tumor growth and patient survival. In the present study, we found that was downregulated in pancreatic ductal adenocarcinoma (PDAC) tissues compared adjacent normal cancer cell differentiation. Overexpression of suppressed vitro vivo induced cycle S phase arrest, no impact on caspase-dependent apoptosis. overexpression also resulted reduced c-Myc expression, an oncogene PDAC, accompanied increased LC3B-II...
Objective . This study aimed at investigating the clinical value of magnetic-guided capsule endoscopy (MGCE) in diagnosis gastrointestinal diseases minors. Methods Eighty-four minor patients hospitalized pediatric department Ruijin Hospital between June 2015 and January 2018 were enrolled for this study. Following bowel preparation, all underwent MGCE. The feasibility, safety, diagnostic yield, sensitivity MGCE analyzed. Patients followed up more than 2 weeks. Results main indications minors...
// Xiao Su 1 , Xiangyi He Qiwen Ben Weiyi Wang 2 Huan Song Qiao Ye Yi Zang Weiguang Li Ping Chen Weiyan Yao and Yaozong Yuan Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School Medicine, 200025, China Eastern Hepatobiliary Second Military Medical University, 200433, Correspondence to: Yuan, email: yyz28@medmail.com.cn Keywords: transglutaminase2, p53 gene, glucose metabolic stress, diabetes-associated pancreatic cancer Abbreviations: TG2: tissue...
Abstract Metastatic disease originates from populations of tumor cells that have the propensity to undergo epithelial-to-mesenchymal transition (EMT), but signals initiate EMT in these not been fully defined. Here we addressed this question mice develop metastatic lung adenocarcinoma owing expression mutant K-ras and p53. We found metastases arose a population had high Notch ligands. Jagged2 promoted by Notch-dependent suppression microRNA-200 (miR-200), family miRs negatively regulates ZEB...
Methylenediphenyl diisocyanate (MDI) was used as the chain extender for low molecular weight poly(lactic acid) (PLA) to produce high biodegradable polymer material with a better heat resistance. PLA prepolymer number-average (Mn) of 5800 and weight-average (Mw) 9800 produced by direct polycondensation using stannous octoate catalyst. After 40 min extension at 175°C, resulting had Mn 15,000 Mw 57,000. The glass transition temperature (Tg) 48.6°C. extension, Tg raised 67.9°C, determined DSC....