A5102909916- Neuroscience and Neuropharmacology Research
- Cannabis and Cannabinoid Research
- Alzheimer's disease research and treatments
- Nanoplatforms for cancer theranostics
- Plant tissue culture and regeneration
- Photodynamic Therapy Research Studies
- Hip disorders and treatments
- Cancer, Hypoxia, and Metabolism
- Pelvic and Acetabular Injuries
- Luminescence and Fluorescent Materials
- Phosphodiesterase function and regulation
- Orthopaedic implants and arthroplasty
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience of respiration and sleep
- Tryptophan and brain disorders
- Pharmacological Receptor Mechanisms and Effects
- HIV/AIDS drug development and treatment
- Cancer Research and Treatments
- Receptor Mechanisms and Signaling
- Multiple Myeloma Research and Treatments
- S100 Proteins and Annexins
- Plant-Microbe Interactions and Immunity
- Antimicrobial Peptides and Activities
- Functional Brain Connectivity Studies
- Amyotrophic Lateral Sclerosis Research
First Affiliated Hospital of Jinan University
2020-2024
Second Hospital of Hebei Medical University
2024
Hebei Medical University
2024
Third Hospital of Hebei Medical University
2024
Hebei General Hospital
2024
Huazhong Agricultural University
2017-2020
University of Pittsburgh
2013-2018
UPMC Hillman Cancer Center
2016
Xi'an Jiaotong University
2014-2015
First Affiliated Hospital of Xi'an Jiaotong University
2013-2014
Abstract Background Alzheimer’s disease (AD) is one of the most burdening diseases century with no disease-modifying treatment at this time. Nonhuman primates (NHPs) share genetic, anatomical, and physiological similarities humans, making them ideal model animals for investigating pathogenesis AD potential therapies. However, use NHPs in research has been hindered by paucity monkey models due to their long generation time, ethical considerations, technical challenges genetically modifying...
The type 2 cannabinoid receptor (CB2R) plays a vital role in carcinogenesis and progression is emerging as therapeutic target for cancers. However, the exact of CB2R cancer therapy remains unclear. This has driven increasing efforts to study cancers using molecular imaging tools. In addition, many types overexpress CB2R, expression levels appear be associated with tumor aggressiveness. Such upregulation cells provides opportunities CB2R-targeted high contrast low side effects. present study,...
Translocator protein 18 kDa (TSPO) positron emission tomography (PET) can be harnessed for the non-invasive detection of macrophage-driven inflammation. [18F]LW223, a newly reported TSPO PET tracer which was insensitive to rs6971 polymorphism, showed favorable performance characteristics in recent imaging study involving rat myocardial infarction model. To enable quantitative neuroimaging with we conducted kinetic analysis non-human primate (NHP) brain. Further, sought assess utility...
Cannabinoid CB2 receptors (CB2R) hold promise as therapeutic targets for treating diverse diseases, such cancers, neurodegenerative pain, inflammation, osteoporosis, psychiatric disorders, addiction, and immune disorders. However, the fundamental role of CB2R in regulation diseases remains unclear, largely due to a lack reliable imaging tools receptors. The goal this study was develop CB2R-targeted molecular probe evaluate specificity using human tumor cells that naturally overexpress CB2R....
The success of targeted cancer therapy largely relies upon the selection target and development efficient therapeutic agents that specifically bind to target. In current study, we chose a cannabinoid CB2 receptor (CB2R) as new used CB2R-targeted photosensitizer, IR700DX-mbc94, for phototherapy treatment. IR700DX-mbc94 was prepared by conjugating IR700DX, mbc94, whose binding specificity CB2R has been previously demonstrated. We found treatment using greatly inhibited growth positive tumors...
Recent studies indicate that the type 2 cannabinoid receptors (CB R ) have become an attractive target for treating a variety of pathologies, including cancers, neurodegenerative diseases, inflammation, pain, osteoporosis, immunological disorders and drug abuse. In addition, it appears many these diseases up-regulated CB expression. However, precise role in regulation remains unclear. The ability to specifically image would contribute develop reliable -based therapeutic approaches with...
Summary During Agrobacterium ( tumefaciens ) infection, the translocated virulence proteins (VirD2, VirE2, VirE3, VirF and VirD5) play crucial roles. It is thought that, through protein–protein interactions, uses abuses host plant factors systems to facilitate its infection. Although some molecular functions have been revealed, roles of VirD5 still need be further elucidated. Here, transformation tumorigenesis mediated by genetically modified strains were performed examine In addition,...
cKIT kinase inhibitors, e.g., imatinib, could induce drug-acquired mutations such as T670I that rendered drug resistance after chronic treatment. Through a type II inhibitor design approach we discovered highly potent compound 35 (CHMFL-KIT-8140), which potently inhibited both wt (IC50 = 33 nM) and gatekeeper mutant 99 nM). Compound displayed strong antiproliferative effect against GISTs cancer cell lines GIST-T1 (cKIT wt, GI50 4 GIST-5R T670I, 26 In the cellular context it strongly c-KIT...
Patients with refractory epilepsy are not only free of seizures after resecting epileptic foci, but also experience significantly improved quality life. Fluorine-18-fluorodeoxyglucose positron-emission tomography (18F-FDG PET) is a promising avenue for detecting foci in patients magnetic resonance imaging (MRI)-negative epilepsy. However, the detection by visual assessment based on 18F-FDG PET often complicated variety factors clinical practice. Easy methods images, such as statistical...
Cannabinoids are emerging as promising antitumor drugs. However, complete tumor eradication solely by cannabinoid therapy remains challenging. In this study, we developed a far-red light activatable prodrug, which allows for tumor-specific and combinatory photodynamic therapy. This prodrug consists of phthalocyanine photosensitizer (PS), reactive oxygen species (ROS)-sensitive linker, cannabinoid. It targets the type-2 receptor (CB2R) overexpressed in various types cancers. Upon 690-nm...
As a member of cyclic nucleotide phosphodiesterase (PDE) enzyme family, PDE10A is in charge the degradation adenosine (cAMP) and guanosine monophosphates (cGMP). While primarily expressed medium spiny neurons striatum, it has been implicated variety neurological disorders. Indeed, inhibition proven to be potential use for treatment central nervous system (CNS) pathologies caused by dysfunction basal ganglia-of which striatum constitutes largest component. A PDE10A-targeted positron emission...
Here we report a near infrared, water-soluble, functional and dendrimeric photosensitizer (PS) based on quinoxalinoporphyrazine structure. The photophysical properties in vitro photodynamic therapy results suggest that this quinoxalinoporphyrazine-based dendrimer may serve as an efficient infrared (NIR) PS platform.
Cholesterol-rich regions are attractive targets for studying metabolic disorders that involve accumulation of cholesterol. Despite efforts to develop probes labelling cholesterol-rich in cells, few these reagents have a low molecular weight. Previous studies shown the acidotropic pH indicator, N-{3-[(2,4-dinitrophenyl)amino]propyl}-N-(3-aminopropyl)methylamine dihydrochloride (DAMP), reacts with organelles, such as endocrine secretary granules from cells. In this study, we demonstrated DAMP...
A series of photostable, hydrophilic and functional near infrared quaterrylenediimide-cored dendrimers (QR-4Gn-COOH, n=1-5) based on polyamides were developed. Preliminary in vitro fluorescence imaging QR-4G5-COOH showed that the dendrimer was primarily located cytoplasm.
Cynomolgus monkeys are widely used in studies related to osteoporosis, and there is no evidence of age-related changes volumetric bone mineral density (vBMD) measured using quantitative computed tomography (QCT) nonhuman primates. This study aimed describe the characteristics lumbar vBMD with age, analyze relationship between body composition, investigate precision QCT measurements healthy female cynomolgus monkeys.Age-related were described cubic regression models, accumulated loss rates...