A5042302114- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Neurogenesis and neuroplasticity mechanisms
- RNA Interference and Gene Delivery
- Alzheimer's disease research and treatments
- Cancer Cells and Metastasis
- Nuclear Receptors and Signaling
- Advanced Neuroimaging Techniques and Applications
- Wound Healing and Treatments
- MicroRNA in disease regulation
- S100 Proteins and Annexins
- Pluripotent Stem Cells Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Nerve injury and regeneration
German Center for Neurodegenerative Diseases
2022-2024
Ludwig-Maximilians-Universität München
2018-2019
Helmholtz Zentrum München
2018-2019
Institute of Molecular Biology and Pathology
2014
Abstract A hallmark of nervous system aging is a decline white matter volume and function, but the underlying mechanisms leading to pathology are unknown. In present study, we found age-related alterations oligodendrocyte cell state with reduction in total density murine matter. Using single-cell RNA-sequencing, identified interferon (IFN)-responsive oligodendrocytes, which localize proximity CD8 + T cells Absence functional lymphocytes decreased number IFN-responsive oligodendrocytes...
Astrocytes are particularly promising candidates for reprogramming into neurons, as they maintain some of the original patterning information from their radial glial ancestors. However, to which extent position astrocytes influences fate reprogrammed neurons remains unknown. To elucidate this, we performed stab wound injury covering an entire neocortical column, including gray matter (GM) and white (WM), targeted local reactive via injecting FLEx switch (Cre-On) adeno-associated viral (AAV)...
Article9 April 2018Open Access Transparent process Cross-talk between monocyte invasion and astrocyte proliferation regulates scarring in brain injury Jesica Frik Physiological Genomics, Biomedical Center, Ludwig-Maximilians-University Munich, Germany Institute for Stem Cell Research, Helmholtz Center Instituto de Biotecnología y Biología Molecular, UNLP-CONICET, La Plata, Argentina Search more papers by this author Juliane Merl-Pham Research Unit Protein Science, Nikolaus Plesnila Stroke...
Abstract Age-related myelin damage induces inflammatory responses, yet its involvement in Alzheimer’s disease remains uncertain, despite age being a major risk factor. Using mouse model of disease, we found that amyloidosis itself triggers age-related oligodendrocyte and damage. Mechanistically, CD8 + T cells promote the progressive accumulation abnormally interferon-activated microglia display myelin-damaging activity. Thus, our data suggest immune responses against myelinating...
The neurotrophins Ngf, Bdnf, NT-3, NT4–5 have key roles in development, survival, and plasticity of neuronal cells. Their action involves broad gene expression changes at the level transcription translation. MicroRNAs (miRs)—small RNA molecules that control post-transcriptionally—are increasingly implicated regulating development neural Using PC12 cells as a model system, we show Ngf modulates variety microRNAs, including miRs known to be modulated by neurotrophins—such miR-212/132...
Abstract Traumatic brain injury frequently affects the cerebral cortex, yet little is known about differential effects that occur if only gray matter (GM) damaged or also involves white (WM). To tackle this important question and directly compare similarities differences in reactive gliosis, we performed stab wound affecting GM WM (GM+) one restricted to (GM−) adult murine cortex. First, examined glial reactivity regions affected (WM GM) determined influence of on gliosis comparing same area...
SUMMARY A hallmark of nervous system aging is a decline white matter volume and function, but the underlying mechanisms leading to pathology are unknown. Here, we found age-related alterations oligodendrocytes with reduction total oligodendrocyte density in murine matter. Using single-cell RNA sequencing, identify interferon-responsive oligodendrocytes, which localize proximity CD8 + T cells Absence functional lymphocytes decreased reactivity rescued loss, while T-cell checkpoint inhibition...