A5099590225- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Long-Term Effects of COVID-19
- Alzheimer's disease research and treatments
- Infectious Encephalopathies and Encephalitis
- Thermal Regulation in Medicine
- Sphingolipid Metabolism and Signaling
- Lysosomal Storage Disorders Research
- Autoimmune and Inflammatory Disorders Research
German Center for Neurodegenerative Diseases
2024-2025
Abstract Age-related myelin damage induces inflammatory responses, yet its involvement in Alzheimer’s disease remains uncertain, despite age being a major risk factor. Using mouse model of disease, we found that amyloidosis itself triggers age-related oligodendrocyte and damage. Mechanistically, CD8 + T cells promote the progressive accumulation abnormally interferon-activated microglia display myelin-damaging activity. Thus, our data suggest immune responses against myelinating...
SARS-CoV-2 infection is associated with long-lasting neurological symptoms, although the underlying mechanisms remain unclear. Using optical clearing and imaging, we observed accumulation of spike protein in skull-meninges-brain axis human COVID-19 patients, persisting long after viral clearance. Further, biomarkers neurodegeneration were elevated cerebrospinal fluid from COVID proteomic analysis skull, meninges, brain samples revealed dysregulated inflammatory pathways...
Abstract Interest in the role of bis(monoacylglycero)phosphate (BMP) lipids lysosomal function has significantly grown recent years. Emerging evidence highlights BMPs as critical players not only Niemann-Pick disease type C (NPC) but also other pathologies such neurodegeneration, cardiovascular diseases, and cancers. However, selective analysis is hindered by isomeric phosphatidylglycerol (PG) lipids. While this can be addressed chromatographic separation, it poses a significant challenge...