About
Contact & Profiles
A5099590226
Research Areas
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
Universitätsmedizin Göttingen
2024
Abstract Age-related myelin damage induces inflammatory responses, yet its involvement in Alzheimer’s disease remains uncertain, despite age being a major risk factor. Using mouse model of disease, we found that amyloidosis itself triggers age-related oligodendrocyte and damage. Mechanistically, CD8 + T cells promote the progressive accumulation abnormally interferon-activated microglia display myelin-damaging activity. Thus, our data suggest immune responses against myelinating...
10.1038/s41593-024-01682-8
article
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cc-by
Nature Neuroscience
2024-06-27
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