A5040295748- Wound Healing and Treatments
- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Dermatologic Treatments and Research
- Dermatology and Skin Diseases
- Corneal Surgery and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Surgical Sutures and Adhesives
- Periodontal Regeneration and Treatments
- Pluripotent Stem Cells Research
- 3D Printing in Biomedical Research
- Psoriasis: Treatment and Pathogenesis
- Silk-based biomaterials and applications
- Skin Protection and Aging
- Allergic Rhinitis and Sensitization
- Neurogenetic and Muscular Disorders Research
- Health, psychology, and well-being
- Asthma and respiratory diseases
- Antimicrobial agents and applications
- Pressure Ulcer Prevention and Management
- Cardiac Health and Mental Health
- Adipokines, Inflammation, and Metabolic Diseases
- Osteoarthritis Treatment and Mechanisms
- Adipose Tissue and Metabolism
- Infection Control and Ventilation
Sociedad Andaluza de Trasplantes de Órganos y Tejidos
2020-2025
Instituto de Investigación Biosanitaria de Granada
2016-2025
Hospital Universitario Virgen de las Nieves
2021-2025
Wake Forest University
2025
Forest Institute
2025
Universidad de Granada
2024
Université Laval
2023
Complejo Hospitalario Universitario de Granada
2016-2017
Andalusian Agency for Healthcare Quality
2017
Abstract Background There is not an ideal biomaterial for tissue‐engineered skin substitutes (TESSs), and most of the studies or existing therapies use xenogeneic origin natural biomaterials biosynthetic scaffolds. Objective To analyse clinical, histological integration homeostasis parameters a human TESS manufactured with fibrin–hyaluronic acid (HA‐Skin), grafted in immunodeficient mice 8 weeks, compared gold standard treatment (Autograft), fibrin–agarose (AG‐Skin) secondary wound healing...
Osteoarthritis (OA) is one of the most prevalent articular diseases. The identification proteins closely associated with diagnosis, progression, prognosis, and treatment response dramatically required for this pathology. In work, differential serum protein profiles have been identified in OA rheumatoid arthritis (RA) by antibody arrays containing 151 antibodies against 121 antigens a cohort 36 samples. Then validated larger 282 overall immunoreactivity higher pathological situations...
Coronavirus disease 2019 (COVID-19) has increased the frequency of handwashing. There is scarce evidence regarding impact different hand hygiene procedures on skin barrier function in clinical practice.To compare measures healthcare workers daily practice.A randomized controlled trial was conducted. Participants were to sanitize their hands with water and soap, alcohol-based sanitizers (ABHSs), or disinfectant wipes during 8-hour working shift. Epidermal functional parameters, such as...
Background Transepidermal water loss (TEWL), stratum corneum hydration (SCH), and skin surface pH are indicators of barrier integrity. There is scant evidence on normative data for cutaneous homeostasis parameters in healthy individuals. Objectives To develop erythema, melanin, pH, SCH, TEWL; identify differences these variables among different anatomical locations; explore factors that may modify values. Material & methods A cross-sectional study was conducted 87 volunteers (34 males) aged...
For the development of advanced therapies, use primary cells instead cell lines is preferred. The manufacture human tissue-engineered skin substitutes requires efficient isolation and culture protocols allowing a massive expansion in from an initial specimen minimal size. This study compared two protocols, routinely applied clinical laboratories. Epithelial (keratinocytes) dermal (fibroblasts) were isolated cultured three biopsies (N = 3). two-step digestion protocol (LOEX-Protocol) firstly...
Psoriasis is a major global health problem. There need to develop techniques help physicians select the most appropriate cost-effective therapy for each patient. The main objectives of this study are (1) evaluate changes in epidermal barrier function and skin homeostasis after phototherapy (2) explore potentially predictive values assess clinical improvement fifteen sessions phototherapy. A total 76 subjects, 38 patients with plaque-type psoriasis gender- age-matched healthy volunteers, were...
Abstract Background The aim of this in vitro study was to compare side-by-side two models human bilayered tissue-engineered skin substitutes (hbTESSs) designed for the treatment severely burned patients. These are scaffold-free self-assembled substitute (SASS) and plasma-based (HPSS). Methods Fibroblasts keratinocytes from three humans were extracted biopsies (N = 3) cells same donor used produce both hbTESS models. For SASS manufacture, seeded over dermal sheets comprising fibroblasts...
Abstract Human plasma is a natural biomaterial that due to their protein composition widely used for the development of clinical products, especially in field dermatology. In this context, has been as scaffold alone or combined with others cellular human plasma-based skin substitutes (HPSSs). Herein, biological properties (cell viability, cell metabolic activity, secretion profile and histology) several variations HPSS model, regarding (alone six secondary biomaterials – serine, fibronectin,...