To assess the phytochemical constituents, total phenolic content, cytotoxicity and in-vitro antioxidant activity of stem bark extracts Moringa oleifera (M. oleifera) (Moringaceae). Brine shrimp lethality (BSL) bioassay was used to investigate cytotoxic effects. DPPH nitric oxide radical scavenging demonstrate activity. Phytochemical analysis revealed presence tannins, flavonoids, steroids alkaloids. The LC50 values were obtained for as 850 μg/mL petroleum ether extract, 800 chloroform...

The methanol extract of Costus pictus (C. pictus) D. DON (Family: Zingiberaceae) leaf was investigated for its anti-diabetic effect in Wistar Albino rats. Diabetes induced rats by administration single doses alloxan monohydrate (120 mg/kg, i.p.). C. (MECP) at a dose 120 p.o. administered as per day to diabetes-induced period 21 days. MECP on blood glucose, plasma insulin, serum lipid profile [cholesterol, triglycerides, phospholipids, very low-density lipoprotein (VLDL), (LDL), and...

The growing need for high-speed, secure, and sustainable data communication in 6G networks has driven researchers to develop advanced techniques address safety privacy concerns transmission. Quantum Key Distribution (QKD) plays a crucial role enhancing security through quantum mechanics. proposed system introduces novel approach cloud-based secure by combining QKD with hybrid optimization techniques. This integrates Convolutional Neural Networks (CNNs) Long Short-Term Memory (LSTM)...

Introduction: The antihypertensive drug Olmesartan Medoxomil has low oral bioavailability (28%) because it is poorly soluble in water, pre-systemic metabolism, and p-glycoprotein mediated efflux. Objective: goal of current investigation was to design loaded polymeric nanoparticles enhance through administration by using a solvent evaporation technique. Methods: formulation comprises ethyl cellulose, polyvinyl alcohol, Tween 80 as polymer, co-polymer, surfactant different concentrations were...

Background: Breast cancer is a leading cause of cancer-related deaths among women worldwide. The limitations current therapies, including drug resistance and toxicity, emphasize the urgent need for novel, targeted therapeutic agents. 4H-chromen-4-one scaffold has emerged as promising framework developing potent anticancer agents, particularly against MCF-7 breast cells. This study investigates potential derivatives using computational modeling. Objective: To develop an integrative...

In search of potential anticancer drug candidates in ruthenium complexes, a series mononuclear complexes the type [Ru(phen)2(nmit)]Cl2 (Ru1), [Ru(bpy)2(nmit)]Cl2 (Ru2), [Ru(phen)2(icpl)]Cl2 (Ru3), Ru(bpy)2(icpl)]Cl2 (Ru4) (phen=1,10-phenanthroline; bpy=2,2′-bipyridine; nmit=N-methyl-isatin-3-thiosemicarbazone, icpl=isatin-3-(4-Cl-phenyl)thiosemicarbazone) and [Ru(phen)2(aze)]Cl2 (Ru5), [Ru(bpy)2(aze)]Cl2 (Ru6) (aze=acetazolamide) [Ru(phen)2(R-tsc)](ClO4)2 (R=methyl (Ru7), ethyl (Ru8),...

A new reversed-phase high performance liquid chromatography method was developed and validated for the simultaneous determination of losartan potassium atenolol in tablets. The separation achieved on Supelcosil ODS analytical column (25×0.46 cm, i.d., 5 µm) using acetonitrile 25 mM dihydrogen phosphate (45:55 v/v, pH 3.00±0.05) as mobile phase at a flow rate 1.2 ml/min. Detection carried out UV detector 227 nm. validated. successfully applied quantitative analysis Losar beta® total...

Linezolid has a better choice for eradication of methicillin-resistant Staphylococcus aureus (MRSA) infections, but its use is limited because linezolid-induced hepatotoxicity, myelosuppression, and lactic acidosis. This research elucidated the role silymarin against hepatoxicity linezolid therapy in MRSA infected Wistar rats. The rats were rendered neutropenic by an intraperitoneal injection cyclophosphamide injection. injected subcutaneously with 106 CFU/ml MRSA. divided into 6 groups....

Objective This cross-sectional, observational study aimed at finding the prevalence of anxiety and depression in cancer patients correlation with various factors, such as age, sex, marital status, educational occupation, financial support, duration, type care, sort carcinoma, stages malignancy, among attending G. Kuppuswamy Naidu Memorial Hospital, Coimbatore, Tamil Nadu, India from July 2022 to December 2022, using Hospital Anxiety Depression Scale (HADS). Methods A total 162 referred for...

Soil samples were collected from the different locations in Sathuragiri Hills (Western Ghats, Tamilnadu).The Total Fungal Counts soil of analyzed.The percentage frequencies occurrence fungal isolates are identified.The identified based on morphological and cultural characteristics they as Cladosporium sp, Aspergillus niger, Penicillium Alternaria Curvularia Helminthosporium sp flavus.Among maximum amount citric acid levels was produced by niger (2.2 ± 0.001 g/l).The effect pH, temperature,...

AbstractThese ligands (L) show a bidentate behavior, forming octahedral ruthenium complexes. The title complexes were subjected to in-vivo anticancer activity tests against transplantable murine tumor cell line, Ehrlich's Ascitic Carcinoma (EAC) and in-vitro antibacterial several Gram positive negative bacterial strains. [Ru(bpy)2(ihqs)]Cl2 [Ru(bpy)2(hc)]Cl2 (where bpy=2,2′-bipyridine, ihqs=7-iodo-8hydroxy quinoline-5-sulphonic acid hc=3-hydroxy coumarin) showed promising antitumor activity....

A reverse phase HPLC method is described for the determination of rosiglitazone and gliclazide in tablet dosage form. Chromatography was carried on Phenomenix Gemini C 18 column using mixture ammonium phosphate buffer, Acetonitrile methanol ratio 50: 35: 15 v/v as mobile at a flow rate 1 mL min -1 effluent monitored 254 nm. The retention time 3.74 7.84 min. limit detection 4.07μg/mL 1.19 μg/mL. LOQ obtained 12.33 μg/mL 3.612 percentage assay 99.92% 99.82%. validated accuracy precision system...

Objective: An effort was made to design and synthesize the series of sulfadiazine building blocks as a targeted candidate for antimycobacterial activity.Method: The synthesized compounds were subjected preliminary in silico screening study testing their action by doing molecular docking on bioinformatics software, operating environment 2009.10.Result: results obtained from this tool showed that there is best affinity score these target against enzyme InhA Enoyl-(acyl-carrier-protein)...

In order to scientifi cally appraise some of the anecdotal, folkloric, ethno medical uses Pisonia aculeata Linn. (Nyctaginaceae), present study was undertaken examine antitumor activity leaves extract on Ehrlich Ascites Carcinoma (EAC) in mice. Tumor induced mice by intraperitoneal injection cells (1X106 cells/mouse). Ethanol (EEPA) administered experimental animals at doses 250 & 500 mg/kg/day, p.o. Th e effect evaluated using survival time, hematological parameters, increase body weight,...

Objective: To synthesize, evaluate and performing the docking studies of novel formazan derivatives as enoyl-ACP reductase inhibitors.Materials: In present investigation, a series formazans (Ia-d) were synthesized by stirring aryl diazonium salts solution with Schiff's base at 0-5˚C for 2 h. The intermediate azomethine (Schiff base) itself was condensation para aminobenzoic acid dimethylamino benzaldehyde in presence glacial acetic catalyst. antimicrobial activity done these compounds cup...

Objective: The aim of the present work is development new, sensitive, specific, and accurate high-performance liquid chromatographic method for separation determination dapagliflozin its impurities in tablet dosage form.
 Methods: drug was achieved using Hypersil BDS C18 column (250 mm × 4.6 mm, 5 μ) with mobile phase consisted phase-A (Buffer pH 6.5) phase-B (acetonitrile:water 90:10) by gradient program at a flow rate 1 mL/min ultraviolet detection 245 nm.
 Results: Dapagliflozin...

The present study reports an experiment on some derivatives of 2-phenyl-chromen-4-one (flavone ring) have a proven inhibitory activity against variety human pathogens, including antibiotic-resistant Gram-positive and Gram-negative bacteria antifungal activities screened four pathogenic two phytopathogenic fungi. Flavanoid been made through Algar– Flynn–Oyamada reaction from hydroxyacetophenones aromatic-aldehydes. structures the synthesized compounds were elucidated by UV, IR 1H NMR...

Background: The widespread usage of synthetic chemical drugs often contributes to the development drug resistance in clinical pathogens along with hazardous side effects human side. Among those pathogens, Candida albicans is a prime consideration explore. C. wildly causing fungal infection oral cavity well known as candidiasis. This study prompted find some novel natural compounds from medicinal plant, Piper betle against . Methods: Bioactive were extracted betel leaves using different...

A simple, specific, sensitive and rapid Reverse phase high performance liquid chromatographic (RP-HPLC) method has been developed validated for the quantification of Metoprolol Tartrate in small volumes rabbit plasma. The was further extended its pharmacokinetic studies plasma samples after transdermal oral administration. Biological sample preparation involving simple extraction with organic solvent, followed by dilution mobile adopted to eliminate any solvent effects. proven be linear over...