A5049276731- Genomics and Chromatin Dynamics
- Microtubule and mitosis dynamics
- Chromosomal and Genetic Variations
- RNA and protein synthesis mechanisms
- Marine Bivalve and Aquaculture Studies
- Aquaculture Nutrition and Growth
- CRISPR and Genetic Engineering
- Fungal and yeast genetics research
- Genetic and phenotypic traits in livestock
Ocean University of China
2024
BGI Group (China)
2017-2023
BGI Research
2022
Aneuploidy compromises genomic stability, often leading to embryo inviability, and is frequently associated with tumorigenesis aging. Different aneuploid chromosome stoichiometries lead distinct transcriptomic phenotypic changes, making it helpful study aneuploidy in tightly controlled genetic backgrounds. By deploying the engineered SCRaMbLE (synthetic rearrangement modification by loxP-mediated evolution) system newly synthesized megabase Sc2.0 VII (synVII), we constructed a synthetic...
Abstract Aneuploidy compromises genomic stability, often leading to embryo inviability, and is frequently associated with tumorigenesis aging. Different aneuploid chromosome stoichiometries lead distinct transcriptomic phenotypic changes, making it helpful study aneuploidy in tightly controlled genetic backgrounds. By deploying the engineered SCRaMbLE system newly synthesized Sc2.0 megabase VII ( synVII ), we constructed a synthetic disomic yeast screened hundreds of SCRaMbLEd derivatives...