A5102007403- Vagus Nerve Stimulation Research
- Acupuncture Treatment Research Studies
- Immune Response and Inflammation
- Dental Implant Techniques and Outcomes
- Heart Rate Variability and Autonomic Control
- Pharmacological Effects of Natural Compounds
- Botulinum Toxin and Related Neurological Disorders
- Ginseng Biological Effects and Applications
- Immune Cell Function and Interaction
- interferon and immune responses
- Mesenchymal stem cell research
- Ammonia Synthesis and Nitrogen Reduction
- Uterine Myomas and Treatments
- RNA Interference and Gene Delivery
- Management of metastatic bone disease
- Bone Tissue Engineering Materials
- Dental Trauma and Treatments
- Metabolomics and Mass Spectrometry Studies
- Periodontal Regeneration and Treatments
- Psoriasis: Treatment and Pathogenesis
- Acute Myeloid Leukemia Research
- Rheumatoid Arthritis Research and Therapies
- Spinal Fractures and Fixation Techniques
- Tryptophan and brain disorders
- Thyroid and Parathyroid Surgery
South China Agricultural University
2023
Capital Medical University
2010-2022
Beijing Hospital of Traditional Chinese Medicine
2018-2022
China Academy of Chinese Medical Sciences
2020-2022
Zhejiang Hospital
2013-2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2020
The Affiliated Yongchuan Hospital of Chongqing Medical University
2017-2018
Chongqing Medical University
2017-2018
Shandong University
2017
Chinese Academy of Sciences
2014
Nitrogen is one of the most important nutrients needed for plants and algae to survive, photosynthetic ability related nitrogen abundance. Red are unique eukaryotic organisms in evolution algae, as they contain phycobilisomes (PBSs) on their thylakoid membranes. In this report, vivo chlorophyll (Chl) a fluorescence kinetics nitrogen-starved Porphyridium cruentum were analyzed determine effects deficiency performance using multi-color pulse amplitude modulation (PAM) fluorometer. Due...
Flavonoids are well known as a large class of polyphenolic compounds, which have variety physiological activities, including anti-influenza virus activity. The influenza A/WSN/33 infected A549 cells been used to screen drugs from natural flavonoid compounds library. Unexpectedly, some significantly inhibited replication, while the others dramatically promoted replication. In this study, we attempted understand these differences between in their antivirus mechanisms. Hesperidin and kaempferol...
Impaired glucose tolerance (IGT) is a pre-diabetic state of hyperglycemia that associated with insulin resistance, increased risk type II diabetes, and cardiovascular pathology. Recently, investigators hypothesized decreased vagus nerve activity may be the underlying mechanism metabolic syndrome including obesity, elevated levels, high blood pressure. In this pilot randomized clinical trial, we compared efficacy transcutaneous auricular stimulation (taVNS) sham taVNS on patients IGT. 72...
Abstract This trial was designed to test the safety and effectiveness of transcutaneous auricular vagus nerve stimulation (ta-VNS) for patients with refractory epilepsy. Pre-trial：144 were randomly assigned ta-VNS group (n=98) or non-vagus (tn-VNS) control (n=46). Treatment conducted twice per day 24 weeks. After 8, 16 weeks treatment，the evaluated according Modified Engel Scale (four classes). 8 weeks，according medical ethic design, in tn-VNS switched into uniquely. weeks’ treatment 41.0%...
Abstract Virus infection may induce excessive interferon (IFN) responses that can lead to host tissue injury or even death. β-arrestin 2 regulates multiple cellular events through the G protein-coupled receptor (GPCR) signaling pathways. Here we demonstrate also promotes virus-induced production of IFN-β and clearance viruses in macrophages. interacts with cyclic GMP-AMP synthase (cGAS) increases binding dsDNA cGAS enhance (cGAMP) downstream stimulator genes (STING) innate immune responses....
Depression and pain disorders share a high degree of comorbidity. Inflammatory mechanisms play an important role in the pathogenesis depression-chronic somatic In this study, we investigated effects acupuncture on blood brain regional tumor necrosis factor alpha (TNF-α) rats with depression chronic Forty Sprague-Dawley were randomly divided into following 4 groups 10 each: control, model, model treated transcutaneous auricular vagus nerve stimulation (taVNS), electroacupuncture (EA). Chronic...
Therapies treating psoriasis can be categorized into five classes according to their mechanism: anti-metabolites (AM), anti-interleukin-12/23 agents (anti-IL12/23), anti-interleukin-17 (anti-IL17), anti-T-cell agent (ANT), and anti-tumor necrosis factor-α (anti-TNF-α). This network meta-analysis (NMA) aimed give a quantitative systemic evaluation of safety efficacy for the kinds therapies mentioned above. Odds ratios mean differences were calculated evaluate binary continuous outcomes,...
Objective To compare the effects of dexmedetomidine‐remifentanil with traditional analgesia and sedation regimen midazolam‐remifentanil during HIFU treatment uterine fibroids. Design A randomised controlled trial. Setting Department Anesthesia in a single hospital. Population Patients Methods total 80 patients diagnosed fibroids scheduled for selective were randomly divided into dexmedetomidine group (the D group) midazolam M group). At 20 minutes before procedure, received loading dose 0.8...
BMP4 is a key growth factor well known in promoting bone regeneration and has been reported to be able regulate T cell development the thymus. Here, we showed that downregulates activation of naïve CD4+ cells IFN-γ production without increasing regulatory cells. could also moderate glycolysis Hif1α expression. Furthermore, suppressive function on vivo . These findings indicating mechanism by which BMP-4 may via metabolism moderation suggests potential therapeutic supplement autoinflammatory diseases.
To observe the effect of acupoint injection bone mesenchymal stem cells (BMSCs) combined with Chinese herbs benefiting qi for activating blood circulation capillary density and arterioles in skeletal muscle ischemic hind limb diabetes mellitus (DM) rats.A total 80 rats were randomized into a normal sham operation group (10 rats) model (70 rats). Disposable intraperitoneal streptozotocin (STZ, 50.0 mg/kg) was used to establish DM model, 7 subgroups, 10 each one. The subgroups group, herb...
The protein translocated intimin receptor (Tir) from enteropathogenic Escherichia coli shares sequence similarity with the host cellular immunoreceptor tyrosine-based inhibition motifs (ITIMs). ITIMs of Tir are required for Tir-mediated immune and evasion responses. However, underlying molecular mechanism by which regulates remains unclear. Here we demonstrated that β-arrestin 2, is involved in G-protein-coupled (GPCR) signal pathway, interacted an ITIM-dependent manner. For mechanism, found...
Objective To observe the early bone integration of oral implants after injection exogenous nerve growth factor(NGF) and investigate effects NGF on peri-implant osseointegration.Methods Twelve New Zealand white rabbits were used in this study to establish bi-mandible implant model. Then local 1 μg was given right side mandible as experimental group normal saline only injected left control once a day for seven days. The respectively sacrificed at 2,4 8 weeks surgery. implant-bone grinding...