A5036090839- Dementia and Cognitive Impairment Research
- Health and Wellbeing Research
- Health disparities and outcomes
- Sleep and related disorders
- Nutritional Studies and Diet
- Alzheimer's disease research and treatments
- Intergenerational Family Dynamics and Caregiving
- Sleep and Wakefulness Research
- Diverse Approaches in Healthcare and Education Studies
- Health Systems, Economic Evaluations, Quality of Life
- Pregnancy and preeclampsia studies
- Health and Well-being Studies
- Chronic Disease Management Strategies
- Treatment of Major Depression
- Schizophrenia research and treatment
- Family Caregiving in Mental Illness
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Family Support in Illness
- Maternal Mental Health During Pregnancy and Postpartum
- Urban Transport and Accessibility
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Bipolar Disorder and Treatment
- Frailty in Older Adults
- Older Adults Driving Studies
Dongguk University WISE
2016-2025
Dongguk University
2016-2025
Gyeongju University
2018-2024
Kangwon National University Hospital
2021
Seoul National University Hospital
2021
Seoul National University Bundang Hospital
2018-2021
Wonju Severance Christian Hospital
2021
Yonsei University
2021
Duke Medical Center
2008
Clinical Research Institute
2008
To investigate sleep disturbances that induce cognitive changes over 4 years in nondemented elderlies.Data were acquired from a nationwide, population-based, prospective cohort of Korean elderlies (2,238 normal cognition [NC] and 655 mild impairment [MCI]). At baseline 4-year follow-up assessments, sleep-related parameters (midsleep time, duration, latency, subjective quality, efficiency, daytime dysfunction) status measured using the Pittsburgh Sleep Quality Index Consortium to Establish...
Due to an unprecedented rate of population aging, South Korea is facing a dementia epidemic. For this reason, the Korean Longitudinal Study on Cognitive Aging and Dementia (KLOSCAD) was launched in 2009 with support from Health Industry Development Institute investigate epidemiology, biopsychosocial risk factors, outcomes dementia-related conditions.The KLOSCAD first nationwide multi-center population-based prospective cohort study. In October 2010, 12,694 individuals were randomly sampled...
<h3>Objective</h3> To investigate the effects of completed pregnancy with childbirth and incomplete without on late-life cognition risk Alzheimer disease (AD) in women. <h3>Methods</h3> Using pooled data 3,549 women provided by 2 population-based cohort studies, we conducted logistic regression analyses to examine retrospectively associations risks mild cognitive impairment AD. For dementia, also covariance Mini-Mental State Examination (MMSE) score. <h3>Results</h3> Grand multiparous who...
ABSTRACT Background: Social support programs for dementia caregivers were widely used in order to reduce care burden. We investigated which types of social supports can psychological and non-psychological burdens caregivers, explored the mechanism those supports. Methods: evaluated 731 community-dwelling patients their from National Survey Dementia Care South Korea. five (emotional support, informational tangible positive interaction, affectionate support) using Medical Outcomes Study...
Background:Mild cognitive impairment (MCI) is a state that lies on the continuum between normal aging and dementia, prevalence of MCI higher than dementia. However, risk for mortality people with has been far less studied po pulation attributable percent (PAR%) death to not estimated yet. Objective:To investigate impact cause in elderly, estimate PAR% deaths MCI. Methods:Data came from 7,315 elderly subjects aged ≥60 years without dementia two cohort studies diagnostic assessments at...
Abstract Background Dementia shows sex difference in its epidemiology. Childbirth, a distinctive experience of women, is associated with the risk for various diseases. However, association dementia women has rarely been studied. Methods We harmonized and pooled baseline data from 11 population-based cohorts countries over 3 continents, including 14,792 aged 60 years or older. investigated between parity using logistic regression models that adjusted age, educational level, hypertension,...
Abstract Aims To investigate the association between parity and risk of incident dementia in women. Methods We pooled baseline follow-up data for community-dwelling women aged 60 or older from six population-based, prospective cohort studies four European two Asian countries. investigated using Cox proportional hazards regression models adjusted age, educational level, hypertension, diabetes mellitus cohort, with additional analysis by subtype (Alzheimer (AD) non-Alzheimer (NAD)). Results Of...
To investigate the effects of single sensory impairment (SSI; visual or auditory) dual (DSI; and on dementia longitudinal changes neuropsychological test scores.In this nationwide, prospective, community-based elderly cohort study, KLOSCAD (the Korean Longitudinal Study Cognitive Aging Dementia), 6,520 individuals (58-101 years) representing general population were included. We defined auditory via self-report questionnaire: 932 had normal function, 2,957 an SSI, 2,631 a DSI. Demographic...
Abstract Background There are growing concerns about the impact of COVID-19 pandemic on mental health older adults. We examined effect risk depression in Methods analyzed data from prospective cohort study Korean adults, which has been followed every 2 years. Among 2308 participants who completed both third and fourth follow-up assessments, 58.4% their before outbreak rest it during pandemic. conducted face-to-face diagnostic interviews using Mini International Neuropsychiatric Interview...
Background Dementia is a major public health challenge, yet existing prediction models often overlook sleep-related symptoms, despite their known links to cognitive decline. Objective To develop and validate four-year Risk Score (DRS) incorporating self-reported symptoms with demographic clinical factors predict all-cause dementia, including Alzheimer's disease. Methods Data from 3082 Korean adults aged 60–79 years were analyzed. Predictors selected using LASSO regression included in...
Subsyndromal depression is prevalent and associated with poor outcomes in late life, but its epidemiological characteristics have barely been investigated. The aim of this prospective cohort study to compare the prevalence, incidence risk factors subsyndromal those syndromal including major minor depressive disorders community-dwelling elderly individuals.In a nationwide community-based randomly sampled Korean population aged 60 years or older (N = 6640), was assessed standardized diagnostic...
<h3>Importance</h3> Although couples could share many risk factors of cognitive disorders in their lifetime, whether shared mediate the has rarely been investigated. <h3>Objective</h3> To identify decline within and investigate mediating roles functions couples. <h3>Design, Setting, Participants</h3> A prospective cohort study was launched November 1, 2010, 784 participants were followed up every 2 years until December 31, 2020. This nationwide, multicenter, community-based included older...
As South Korea is at the forefront of a worldwide eruption dementia, has been an effort to grapple with dementia. The Korean Longitudinal Study on Cognitive Aging and Dementia (KLoSCAD) was developed gain further understanding how social, biomedical, environmental factors are associated dementia in compare it other races countries. main objectives KLoSCAD were 1) estimate epidemiology related disorders 2) investigate diagnostic markers for normative data cognitive function 3) develop...
Hyperhomocysteinemia has been repeatedly found to increase the risk of dementia. However, effects hypohomocysteinemia on dementia have barely investigated. If hypohomocysteinemia, like hyperhomocysteinemia, increases dementia, misuse or overuse homocysteine-lowing agents such as vitamin supplements may dementia.To investigate whether could and Alzheimer's disease (AD) in a large population-based cohort older adults.This prospective study followed 2655 randomly sampled, community-dwelling,...
To examine the impact of revised diagnostic criteria for neurocognitive disorders (NCDs) in Diagnostic and Statistical Manual Mental Disorders, 5th edition (DSM-5) on prevalence dementia mild cognitive impairment (MCI).A total 755 participants aged 65 years or older Nationwide Survey Dementia Epidemiology Korea 2012 were rediagnosed according to DSM-5 criteria.The estimated age-, gender-, education-, urbanicity-standardized rates major NCDs 8.35 11.10%, respectively, those MCI 8.74 31.85%,...
We investigated the effects of lifetime cumulative ginseng intake on cognitive function in a community-dwelling population-based prospective cohort Korean elders. Community-dwelling elders (N = 6422; mean age 70.2 ± 6.9 years, education 8.0 5.3 female 56.8%) from Longitudinal Study Cognitive Aging and Dementia were included. Among them, 3918 participants (61.0%) completed 2-year 4-year follow-up evaluations. Subjects categorized according to at baseline evaluation; no use group, low (< 5...
Dementia increases the risk of mortality (ROM) in elderly and estimates hazard ratio (HR) dementia for have ranged from 1.7 to 6.3. However, previous studies may underestimated ROM due length bias, which occurs when failing include persons with rapidly progressive diseases, who died before they could be included study. This population-based prospective cohort study conducted on 6,752 randomly sampled Koreans, aged 60 years or older (the Korean Longitudinal Study Cognitive Aging Dementia)....
We investigated the prevalence and risk factors of physically abusive behaviors (PhAB) psychologically (PsAB) towards people with dementia (PWD) in family caregivers, compared their prevalences between East Asian Western countries.We estimated PhAB PsAB 467 Korean pairs community-dwelling PWD primary caregivers. evaluated using Modified Conflict Tactics Scale. In addition, we countries through a meta-analysis on 12 studies including current one.More than half caregivers reported about one...
Objectives: Subsyndromal depression is prevalent and associated with poor outcomes in late life, but its effect on the risk of dementia has barely been investigated. This study aimed to investigate subsyndromal cognitively normal older adults patients mild cognitive impairment. Methods: Data were collected from a nationwide, population-based, prospective cohort randomly sampled Korean elderly population aged 60 years or older, which followed every 2 years. Using 6-year follow-up data 4456...
Despite its significance as a contributing factor for late-life dementia risk, illiteracy is frequently underappreciated in the management of dementia. In this study, we estimated proportion cases attributable to using population fraction (PAF), and calculated what extent monetary cost could be saved future by reducing from South Korean, Latin American, Asian/Middle Eastern, African populations. We collected necessary data 2011 United Nations Human Development Report prevalence studies...
Measurements of patient quality life (QoL) play a major role in the management dementia.We investigated self-proxy discrepancy QoL ratings elderly and impact dementia severity on discrepancy.QoL 718 patients with 651 non-demented were rated by themselves their caregivers (CG) using Quality Life-Alzheimer's Disease (QoL-AD). The rater total item scores QoL-AD was analyzed repeated measures ANOVA differential response patterns between self proxy functioning (DIF) analysis.Self-rated higher...
Prospective studies concerning sleep architecture and cognitive function have focused on individual measures per se, without considering the complementary role of non-REM (NREM) REM sleep. We explored association between NREM/REM cycle-related decline. Community-dwelling elderly people in Korea from Korean Longitudinal Study Cognitive Aging Dementia were enrolled. They cognitively normal underwent overnight polysomnography at baseline. A cycle is a sequence NREM sleep, uninterrupted by...
We investigated the impact of depressed mood (dysphoria) and loss interest or pleasure (anhedonia)on risk dementia in cognitively-normal elderly individuals.This study included 2,685 individuals who completed baseline 4-year follow-up assessments Korean Longitudinal Study on Cognitive Aging Dementia. ascertained presence dysphoria anhedonia using Mini International Neuropsychiatric Inventory. defined subjective cognitive decline as complaints without objective impairments. analyzed...