A5071536171- Vitamin D Research Studies
- Cardiovascular Health and Risk Factors
- Cardiovascular Disease and Adiposity
- Obstructive Sleep Apnea Research
- Parathyroid Disorders and Treatments
- Blood Pressure and Hypertension Studies
- Atrial Fibrillation Management and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Magnesium in Health and Disease
- Inflammatory mediators and NSAID effects
- Mechanical Circulatory Support Devices
- Sleep and related disorders
- Nutritional Studies and Diet
- Sleep and Wakefulness Research
- Lipoproteins and Cardiovascular Health
- Heart Failure Treatment and Management
- Alzheimer's disease research and treatments
- Cardiovascular Function and Risk Factors
- Diet and metabolism studies
- Acute Myocardial Infarction Research
- Dementia and Cognitive Impairment Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cardiac Health and Mental Health
- Fatty Acid Research and Health
- Health, Environment, Cognitive Aging
University of Minnesota
2016-2025
University of Minnesota System
2024-2025
Minnesota Department of Health
2015-2024
Minneapolis Heart Institute Foundation
2014-2021
University of Minnesota Medical Center
2014-2020
Mayo Clinic
2019
Johns Hopkins University
2014-2019
Department of Medical Sciences
2019
University of Mississippi Medical Center
2015-2019
Emory University
2019
Background— Aspirin for the primary prevention of coronary heart disease (CHD) is only recommended individuals at high risk CHD although majority events occur in who are low to intermediate risk. Methods and Results— To estimate potential artery calcium (CAC) scoring guide aspirin use CHD, we studied 4229 participants from Multi-Ethnic Study Atherosclerosis were not on baseline free diabetes mellitus. Using data median 7.6-year follow-up, 5-year number-needed-to-treat estimations calculated...
Good sleep is essential for health, yet associations between and dementia risk remain incompletely understood. The Sleep Dementia Consortium was established to study polysomnography (PSG)-derived the of related cognitive brain magnetic resonance imaging endophenotypes.
This study tested the hypotheses that late-midlife obstructive sleep apnea (OSA) and short long duration are associated with dementia over 15 years of follow-up.A total 1667 Atherosclerosis Risk in Communities Study participants underwent in-home polysomnography (1996-1998) were followed for dementia. Dementia was defined by (1) hospitalization diagnosis codes (1996-2012) (2) a comprehensive neurocognitive examination (2011-2013) adjudication.OSA not risk incident When using adjudicated...
Background— Physical activity (PA) has previously been suggested to attenuate the risk of atrial fibrillation (AF) conferred by excess body weight and gain. We prospectively examined relationship between size, change, level PA in a biracial cohort middle-aged men women. Methods Results— Baseline characteristics on factor levels were obtained 14 219 participants from Atherosclerosis Risk Communities Study. AF incidence was ascertained 1987 2009. Adjusted Cox proportional hazards models used...
Abstract BACKGROUND Vitamin D deficiency is associated with poor bone health and other adverse outcomes; however, the associations are greatly attenuated in black vs white individuals. One possible explanation for this attenuation different concentrations of bioavailable vitamin metabolites plasma, which estimated equations that include total concentration binding globulin (VDBG) haplotype-specific dissociation constants. METHODS We developed a method to quantify VDBG LC-MS/MS could also...
<h3>Background</h3> Elevated levels of circulating liver enzymes have been associated with increased risk cardiovascular disease. Their possible association atrial fibrillation (AF) has received little attention. <h3>Methods</h3> We studied 9333 men and women, aged 53–75 years, free AF, participating in the Atherosclerosis Risk Communities Study followed-up from 1996 to 2010. Aspartate aminotransferase (AST), alanine (ALT), γ glutamyl transpeptidase (GGT) were measured stored plasma samples....
Multiple gated acquisition scanning (MUGA) is a common imaging modality for baseline and serial assessment of left ventricular ejection fraction (LVEF) cardiotoxicity risk prior to, surveillance during, after administration potentially cardiotoxic cancer treatment. The objective this study was to compare the accuracy fractions obtained by contemporary clinical multiple scans with reference LVEFs from cardiovascular magnetic resonance (CMR) in consecutive patients cancer. In cross-sectional...
Abstract Introduction Phospholipids are altered in brains of patients with dementia and some studies suggest their plasma levels may be useful the detection mild cognitive impairment (MCI) dementia. Methods We measured 188 metabolites participants who underwent a detailed neuropsychological assessment classified as normal (n = 153), MCI 145), or 143) by expert adjudication. Results Among 10 phospholipids recently implicated dementia, higher concentration PC aa C36:6 was significantly...
Importance Factors associated with the risk of dementia remain to be fully understood. Systemic infections are hypothesized such factors and may targets for prevention screening. Objective To investigate association between hospitalization infection incident dementia. Design, Setting, Participants Data from community-based Atherosclerosis Risk in Communities (ARIC) study, a prospective cohort were used. Enrollment occurred at 4 research centers US, initiated 1987 1989. The present study...
Background The immune response to infections may become dysregulated and promote myocardial damage contributing heart failure (HF). We examined the relationship between infection‐related hospitalization (IRH) HF, HF with preserved ejection fraction, reduced fraction. Methods Results studied 14 468 adults aged 45 64 years in ARIC (Atherosclerosis Risk Communities) Study who were free at visit 1 (1987–1989). IRH was identified using select International Classification of Diseases ( ICD ) codes...
Background: Low serum magnesium (Mg) has been associated with an increased risk of cardiovascular disease (CVD), including ventricular arrhythmias, but the association between or dietary Mg and atrial fibrillation (AF) not investigated. Methods Results: A total 14,290 men women (75% white; 53% female; mean age, 54 years) free AF at baseline participating in Atherosclerosis Risk Communities study United States, were studied. Incident cases through 2009 ascertained from electrocardiograms,...
Background No previous studies have examined the interplay among socioeconomic status, sex, and race with risk of atrial fibrillation ( AF ). Methods Results We prospectively followed 14 352 persons (25% black, 75% white, 55% women, mean age 54 years) who were free participating in Atherosclerosis Risk Communities ARIC ) study. S ocioeconomic status was assessed at baseline (1987–1989) through educational level total family income. Incident 2009 ascertained from electrocardiograms,...
The effect of dietary protein on the risk stroke has shown inconsistent results. We aimed to evaluate relationship sources with and silent cerebral infarcts in a large community-based cohort.We studied 11601 adults (age, 45-64 years at baseline 1987-1989) enrolled Atherosclerosis Risk Communities (ARIC) Study, free diabetes mellitus cardiovascular disease. Dietary intake was assessed validated food frequency questionnaires after 6 follow-up. Incident events were identified through hospital...
Increased concentrations of circulating fibroblast growth factor 23 (FGF-23) have been associated with higher risk cardiovascular disease. The association between FGF-23 and the atrial fibrillation (AF), a common arrhythmia, is less defined. Thus, we explored whether concentration was AF incidence in large community-based cohort.We studied 12 349 men women enrolled Atherosclerosis Risk Communities (ARIC) study, without prevalent at baseline 1990-1992. Serum intact measured Kainos 2-site...
Abstract Introduction The objective of this study was to investigate whether 10 phospholipids/metabolites previously identified as prospectively predictive mild cognitive impairment (MCI) or dementia in whites would also be a mostly African‐American cohort. Methods We repeatedly measured 188 plasma samples 221 participants the Atherosclerosis Risk Communities study, 97% African American, who were followed between 2004–2006 and 2011–2013. Results After mean follow‐up 7.3 years, 77 classified...
Background Relatively little is known about the long-term consequences of venous thromboembolism (VTE) on physical functioning. We compared frailty status, function, and quality life among survivors VTE with coronary heart disease (CHD) stroke, those without these diseases. Methods Results Cases VTE, CHD, stroke were continuously identified since ARIC (Atherosclerosis Risk in Communities Study) recruitment during 1987 to 1989. Functional measures objectively captured at clinic visits 5...