A5073307802- Advanced Fluorescence Microscopy Techniques
- Gold and Silver Nanoparticles Synthesis and Applications
- Microfluidic and Capillary Electrophoresis Applications
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Lipid Membrane Structure and Behavior
- Plasmonic and Surface Plasmon Research
- Near-Field Optical Microscopy
- Force Microscopy Techniques and Applications
- Polymer Surface Interaction Studies
- Microfluidic and Bio-sensing Technologies
- Microtubule and mitosis dynamics
- RNA Interference and Gene Delivery
- Advanced Electron Microscopy Techniques and Applications
- Quantum Dots Synthesis And Properties
- Nanopore and Nanochannel Transport Studies
- Cellular Mechanics and Interactions
- Innovative Microfluidic and Catalytic Techniques Innovation
- Cellular transport and secretion
- Characterization and Applications of Magnetic Nanoparticles
- Mesenchymal stem cell research
- Nanoplatforms for cancer theranostics
- Advanced Biosensing Techniques and Applications
- Photosynthetic Processes and Mechanisms
- Photoacoustic and Ultrasonic Imaging
Beihang University
2022-2025
Collaborative Innovation Center of Chemistry for Energy Materials
2022-2025
Xiamen University
2021-2025
Qingdao University
2020-2024
Changchun University
2022-2024
Harbin Medical University
2022-2024
First Affiliated Hospital of Harbin Medical University
2022-2024
Nanjing University
2023-2024
First Hospital of Jilin University
2024
Jilin University
2024
To further our understanding on the antibacterial activity of single-walled carbon nanotubes (SWCNTs), high purity SWCNTs with average diameter 0.83 nm and (7,5) chirality as dominate (n,m) structure were dispersed in a biocompatible surfactant solution. Ultraviolet−visible−near-infrared radiation absorption spectroscopy was employed to monitor aggregation SWCNTs. The results demonstrated that individually more toxic than SWCNT aggregates toward bacteria (gram-negative Escherichia coli,...
Chitosan has demonstrated its potentials as a gene carrier and membrane perturbant for subsequent drug delivery to cells. However, there is currently lack of experimental correlation between the physiochemical properties chitosan resulting degree lipid bilayer destabilization. In this study, effect pH molecular weight on interaction dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) was examined with cross-polarization microscopy, differential scanning calorimetry (DSC), Fourier transform- (FT-)...
Significance Metastasis is the primary cause of cancer-related deaths. Current clinical treatments for antimetastasis, however, are not effective. This work aims to develop a strategy inhibit cancer cell migration using gold nanorods (AuNRs) with systematic understanding mechanism. The ability targeting AuNRs surface integrins and introduction NIR light generate mild plasmonic photothermal effect caused broad regulation on cytoskeletal proteins, thus impairing migration. provides potential...
Gold nanorods are excellent orientation probes due to their anisotropic optical properties. Their dynamic rotational motion in the 3D space can be disclosed with Nomarski-type differential interference contrast (DIC) microscopy. We demonstrate that by using combination of gold nanorod and DIC microscopy, we able resolve motions nano-cargos transported motor proteins at video rate not only on engineered surfaces but also cytoskeleton tracks live cells.
Metal-semiconductor heterostructures are promising visible light photocatalysts for many chemical reactions. Here, we use high-resolution superlocalization imaging to reveal the nature and photocatalytic properties of surface reactive sites on single Au-CdS hybrid nanocatalysts. We experimentally two distinct, incident energy-dependent charge separation mechanisms that result in completely opposite photogenerated (e(-) h(+)) divergent energy flows find plasmon-induced hot electrons Au...
Most cancer patients die from metastasis. Recent studies have shown that gold nanoparticles (AuNPs) can slow down the migration/invasion speed of cells and suppress Since nuclear stiffness cell largely decreases migration, our hypothesis is targeting AuNPs to nucleus region could enhance stiffness, therefore inhibit migration invasion. Our results showed upon AuNPs, ovarian motilities decrease significantly, compared with nontargeted AuNPs. Furthermore, using atomic force microscopy, we...
Most cancer-related deaths come from metastasis. It was recently discovered that nanoparticles could inhibit cancer cell migration. Whereas most researchers focus on single-cell migration, the effect of nanoparticle treatment collective migration has not been explored. Collective occurs commonly in many types metastasis, where a group cells move together, which requires contractility cytoskeleton filaments and connection neighboring by junction proteins. Here, we demonstrate gold nanorods...
Abstract Objectives Circadian rhythm controls complicated physiological activities in organisms. clock genes have been related to tumour progression, but its role glioma is unknown. Therefore, we explored the relationship between dysregulated circadian and progression. Materials Methods Samples were divided into different groups based on gene expression training dataset (n = 672) verified results other four validating datasets 1570). The GO GSEA enrichment analysis conducted explore...
Engineered nanoparticles have emerged as potentially revolutionary drug and gene delivery vectors. Using rod-shaped gold a model, we studied for the first time rotational dynamics of nanoparticle vectors on live cell membranes its impact fate these The motions nanorods with various surface modifiers were tracked continuously at 200 frames/s under differential interference contrast microscope. We found that behaviors nanorod are strongly related to their charges. Specific functional groups...
Abstract Nanoconfinement could dramatically change molecular transport and reaction kinetics in heterogeneous catalysis. Here we specifically design a core-shell nanocatalyst with aligned linear nanopores for single-molecule studies of the nanoconfinement effects. The quantitative measurements reveal unusual lower adsorption strength higher catalytic activity on confined metal centres within nanoporous structure. More surprisingly, effects enhanced are larger catalysts longer narrower...
We report an automated single particle tracking technique for the x, y, z coordinates, azimuthal and elevation angles of anisotropic plasmonic gold nanorod probes in live cells. These five spatial coordinates are collectively referred to as 5D. This method overcomes a long-standing challenge distinguishing rotational motions from translational z-axis differential interference contrast microscopy result full disclosure nanoscale with high accuracy. Transferrin-coated endocytic cargoes...
Applying nanotechnology to plant science requires efficient systems for the delivery of nanoparticles (NPs) cells and tissues. The presence a cell wall in makes it challenging extend NP methods available animal research. In this work, research is presented which establishes an system tissues using biolistic method. It shown that mesoporous silica nanoparticle (MSN) materials can be improved by increasing density MSNs through gold plating. Additionally, DNA-coating protocol used based on...
Gold and silver nanoparticles display extraordinarily large apparent refractive indices near their plasmon resonance (PR) wavelengths. These show good contrast in a narrow spectral band but are poorly resolved at other wavelengths differential interference (DIC) microscopy. The wavelength dependence of DIC gold/silver is interpreted terms Mie's theory working principles. We further exploit this by modifying microscope to enable simultaneous imaging two demonstrate that immobilized on the...
Keeping track: By combining differential interference contrast (DIC) image pattern recognition with DIC polarization anisotropy, the exact full three-dimensional angular information of individual tilted gold nanorods positioned in focal plane objective lens can be readily determined. The rotational modes and kinetics in-focus thus resolved dynamically.