A5006831551- Cardiac, Anesthesia and Surgical Outcomes
- Advanced Electron Microscopy Techniques and Applications
- Blood Pressure and Hypertension Studies
- Diet and metabolism studies
- Airway Management and Intubation Techniques
- Hormonal Regulation and Hypertension
- Renin-Angiotensin System Studies
- Micro and Nano Robotics
- Anesthesia and Pain Management
- Hemodynamic Monitoring and Therapy
- Electron and X-Ray Spectroscopy Techniques
- Atrial Fibrillation Management and Outcomes
- Heparin-Induced Thrombocytopenia and Thrombosis
- Aortic aneurysm repair treatments
- Advanced Materials and Mechanics
- Diabetes Treatment and Management
- Cardiovascular Syncope and Autonomic Disorders
- Heart Rate Variability and Autonomic Control
- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Systemic Lupus Erythematosus Research
- Renal and Vascular Pathologies
- Tracheal and airway disorders
- Central Venous Catheters and Hemodialysis
- Force Microscopy Techniques and Applications
Jichi Medical University
2010-2025
Jichi Medical University Saitama Medical Center
2010-2025
Peptide Institute (Japan)
2022
Toray Industries, Inc. (Japan)
2010-2020
Shibaura Institute of Technology
2015-2020
Toray (United States)
2011-2020
Toyota Motor Corporation (Japan)
2017
Forschungszentrum Jülich
2013
Surugadai Nihon University Hospital
1985-2010
Nihon University
2007
Although angiotensin converting enzyme inhibitors and alpha 1-blockers have been reported to improve insulin sensitivity, their mechanisms of action not elucidated. To investigate the role kinins in we treated 4-week-old spontaneously hypertensive rats with either an inhibitor (enalapril), 1-blocker (doxazosin), or II antagonist (losartan) for 3 weeks. A control group received no drugs. In addition, 18 enalapril doxazosin a simultaneous administration kinin (Hoe 140). Glucose clamp testing...
The Fuel Cell Electrode (FCE), consisting of platinum particles or alloy supported on carbon substrates, is one the key components in polymer electrolyte fuel cells (PEFCs). In order for detailed characterization, it crucial to determine three-dimensional (3D) morphologies Pt nanoparticles substrates (Pt/C). this communication, 3D structures Pt/C with two different kinds have been examined using a nano-scale imaging technique, transmission electron microtomography. It was found that...
We investigated the role of insulin in salt-sensitive hypertension Dahl and salt-resistant rats. The rats were kept metabolic cages, sodium intake urinary excretion measured. In receiving a 0.3% NaCl diet, retention was significantly greater at weeks 1 2 that received an infusion than those saline infusion. Mean arterial blood pressure plasma norepinephrine levels higher week 3 insulin-treated saline-treated (mean pressure, 137 +/- mm Hg versus 119 Hg, p < 0.05; norepinephrine, 0.40 0.02...
Abstract The previously reported gel and polymer actuators require external inputs, such as batteries, circuits, electronic etc., compared with autonomous motions produced by the living organisms. To realize spontaneous motions, here, we propose to integrate a power supply, actuators, control into single-component self-oscillating hydrogel. We demonstrate self-actuating pumps driven oscillatory Belousov–Zhabotinsky (BZ) reaction without components. have developed volume oscillation of gels...
Patients with end-stage renal disease on hemodialysis (HD) undergoing cardiac surgery face increased risks. Mixed venous saturation (SvO2) is an important parameter representing the systemic oxygen supply-demand balance. However, interpreting SvO2 in HD patients may be challenging due to arteriovenous fistulas. The literature these issues lacking. This study aimed investigate change by comparing those non-HD perioperatively. From April 1, 2019, March 31, 2020, 39 pulmonary artery catheters,...
Intercostal nerve block (ICNB) plus intravenous (IV) patient-controlled analgesia (PCA) could be an alternative method of perioperative pain management in patients undergoing video-assisted thoracic surgery (VATS). However, the efficacy this strategy has not been established. A retrospective observational study was conducted at acute care hospital Japan. Among who underwent VATS under general anesthesia from January 1, 2012, to December 31, 2022, we included those received ICNB or epidural...
Cilnidipine has a blocking action against N-type calcium channels as well L-type channels. We studied the effect of morning and bedtime dosing on circadian variation blood pressure (BP), heart rate (HR), activity autonomic nervous system, using an open randomized crossover study in 13 essential hypertensive patients. An automated device allowed 24-hour monitoring ambulatory BP HR power spectrum R-R interval, at observation period, regimen, regimen. Morning with cilnidipine reduced average...
To investigate the effects of a low calorie regimen on sympathetic function and its relation to blood pressure response, 22 untreated obese essential hypertensive patients (50 +/- 2 years, body mass index 29 1 kg/m2) were hospitalized diet was prescribed 2,000 kcal/day for 5 days (control period) followed by 800 21 without changing salt intake (8-10 g/day). The dose intravenous phenylephrine infusion needed elevate systolic 20 mm Hg (CD20) 24-hour urinary excretion norepinephrine (UNE)...
There are several recent reports that left upper lobe lung resection is a risk factor for the development of postoperative thromboembolism. Although administering epidural analgesia common in thoracic surgery, anesthesiologists should be alert when to patient undergoing lobectomy, considering increased thromboembolism and potential need anticoagulation or fibrinolytic therapy immediate period. A seventy-one-year-old female with metastatic lesion developed cerebral infarction approximately 30...
Oxidative stress has been proposed as important in the pathogenesis of hypertension. Measurement 8-iso prostaglandin F2alpha (8-ISO) is introduced for evaluating oxidative vivo. 8-ISO major urinary metabolite F2-isoprostanes and formed nonenzymatically from attack superoxide radicals on arachidonic acid. We examined level Dahl salt-sensitive (Dahl-S) rats salt-resistant (Dahl-R) rats. Dahl-S Dahl-R were fed either a high salt diet (8% NaCl; HS) or low (0.3% LS) 3 weeks, systolic blood...
Abstract Background Tracking preload dependency non-invasively to maintain adequate tissue perfusion in the perioperative period can be challenging.The effect of phenylephrine on stroke volume is dependent upon preload. Changes induced by administration used predict dependency. The change peripheral index derived from photoplethysmography signals reportedly corresponds with changes situations such as body position operating room. Thus, a non-invasive potential alternative Herein, we aimed...
We describe a patient with pacemaker who developed cardiac arrest shortly after ultrasound-guided rectus sheath block for postoperative analgesia. The cause of was capture failure due to an increased pacing threshold, and the promptly treated by increasing amplitude. Local anesthetics used might have affected threshold caused failure, since local can sodium channels. Anesthesiologists should recognize risk when large amount anesthetic is given patients pacemaker.
Nivalenol (NIV) is a trichothecene mycotoxin that more toxic than deoxynivalenol. It accumulates in grains due to infection with Fusarium species, which are the causative agents of scab or head blight. An immunoassay, rapid and easy analytical method, necessary for monitoring NIV grains. However, specific antibody against has not been prepared previously. To establish an we NIV, introduced linker, generated antibodies it. was from culture kyushuense obtained pressed barley through...
Electron staining is generally performed prior to observing organic materials via transmission electron microscopy (TEM) enhance image contrast. However, can deteriorate materials. Here, we demonstrate electrostatic potential imaging of differential phase contrast (DPC) scanning (STEM) without staining. Electrostatic drastically increases the between different Phase-separated structures in a poly (3-hexylthiophene) (P3HT) and [6,6]-phenyl-C61-butyric acid methyl ester (PCBM) blend that are...
Dihydropyridine calcium channel blockers are not uniform in terms of their action on channel. L-type dilate the resistance arterioles. Cilnidipine is a dihydropyridine blocker that also acts N-type channels, and may venules through its effect sympathetic receptor. The influence an (nifedipine) or this L+N type at 10(-7) mol to 10(-4) venular diameter was examined by superfusion male Syrian hamster cheek pouches. Nifedipine dose dependently dilated arterioles alone, whereas cilnidipine both...
Amlodipine, a calcium channel blocker (CCB), is one of the most common antihypertensive medicines in Japan. We evaluated whether confers cardiac protection through renin-angiotensin-aldosterone system male stroke-prone spontaneously hypertensive rats (SHR-SP).Fifteen week-old were divided into 2 groups: amlodipine group (3 mg/kg/day, n = 5) and control (n 5).The CCB lowered systolic blood pressure significantly (P < 0.05). Plasma aldosterone concentration was remarkably lower than 0.05), but...
Abstract Background Anticoagulation management of patients with antiphospholipid syndrome (APS) undergoing cardiac surgery is challenging due to the prolongation activated clotting time (ACT). Currently, no study has compared utility ACT monitoring using Hemochron Jr. Signature+ and that heparin concentration Hemostasis Management System (HMS) Plus in APS. Case presentation A 71-year-old woman APS was scheduled undergo an aortic valve replacement for regurgitation. The measured Signature+,...