A5048068828- Radiation Therapy and Dosimetry
- Electron and X-Ray Spectroscopy Techniques
- Plasma Diagnostics and Applications
- Atomic and Molecular Physics
- Advanced Radiotherapy Techniques
- Radiation Effects in Electronics
- Radiation Detection and Scintillator Technologies
- Laser-induced spectroscopy and plasma
- Photocathodes and Microchannel Plates
- Plasma Applications and Diagnostics
- X-ray Spectroscopy and Fluorescence Analysis
- Laser Design and Applications
- Radiopharmaceutical Chemistry and Applications
- Health, Medicine and Society
- DNA Repair Mechanisms
- Semiconductor materials and devices
- Muon and positron interactions and applications
- Nuclear Physics and Applications
- Catalytic Processes in Materials Science
- Radiation Effects and Dosimetry
- Gas Dynamics and Kinetic Theory
- Mass Spectrometry Techniques and Applications
- Effects of Radiation Exposure
- Spectroscopy and Laser Applications
- Historical and Scientific Studies
Université Toulouse III - Paul Sabatier
2015-2024
Inserm
2015-2024
Centre de Recherche en Cancérologie de Toulouse
2015-2023
University of Wollongong
2019
Centre Hospitalier Universitaire de Rouen
2017-2019
Université de Rouen Normandie
2017-2019
Laboratoire Plasma et Conversion d'Energie
2007-2015
Centre National de la Recherche Scientifique
1982-2015
Institut National Polytechnique de Toulouse
2011-2015
Institut universitaire du cancer de Toulouse Oncopole
2014
This Special Report presents a description of Geant4‐DNA user applications dedicated to the simulation track structures (TS) in liquid water and associated physical quantities (e.g., range, stopping power, mean free path…). These example are included Geant4 Monte Carlo toolkit available open access. Each application is described comparisons recent international recommendations shown ICRU, MIRD), when available. The influence physics models for electron interactions discussed. Thanks these...
LXCat is an open‐access platform ( www.lxcat.net ) for curating data needed modeling the electron and ion components of technological plasmas. The types presently supported on are scattering cross sections swarm/transport parameters, ion‐neutral interaction potentials, optical oscillator strengths. Twenty‐four databases contributed by different groups around world can be accessed LXCat. New contributors welcome; database retain ownership responsible contents maintenance individual databases....
Abstract This paper presents a critical review of the basic data concerning physics and chemistry low pressure SiH 4 glow discharges used to deposit hydrogenated amorphous silicon films (a‐Si:H). Starting with an updated table thermochemical data, we analyze gas‐phase elementary processes consisting i) electron‐molecule collisions, ii) ion‐molecule iii) neutral‐neutral iv) other electron ion collisions involving electron‐ion ion‐ion recombination, attachment on radicals detachment anions, v)...
This paper describes work done in the context of Gaseous Electronics Conference (GEC) Plasma Data Exchange Project (PDEP) as discussed preface to this cluster issue. The purposes and its companion papers are compare sets cross sections for electron scattering from ground-state noble gas atoms energy range thermal about 1 keV comment on their applicability plasma modelling. To these ends, we present intercomparisons nine independently derived argon that have been posted databases LXCat...
This paper is the second of a series four reports, describing work carried in 2011 context Plasma Data Exchange Project with Gaseous Electronics Conference, devoted to intercomparisons between different sets electron–neutral scattering cross sections from ground-state noble gas atoms, energy range thermal about 1 keV. The present compares section for helium and neon, determined independently, which are available on open access LXCat website (www.lxcat.laplace.univ-tlse.fr/). used as input...
The biological effects of ionizing radiation at the cellular level are frequently studied using well-known formalism microdosimetry, which provides a quantitative description stochastic aspects energy deposition in irradiated media. Energy can be simulated Monte Carlo codes, some adopting computationally efficient condensed-history approach, while others follow more detailed track-structure approach. In this work, we present simulation microdosimetry spectra and related quantities...
Abstract Ionising radiation induced DNA damage and subsequent biological responses to it depend on the radiation’s track-structure its energy loss distribution pattern. To investigate underlying mechanisms involved in such complex system, there is need of predicting response by integrated Monte Carlo (MC) simulations across physics, chemistry biology. Hence, this work, we have developed an application using open source Geant4-DNA toolkit propose a realistic “fully integrated” MC simulation...
Purpose Gold nanoparticles (GNPs) are known to enhance the absorbed dose in their vicinity following photon‐based irradiation. To investigate therapeutic effectiveness of GNPs, previous Monte Carlo simulation studies have explored GNP enhancement using mostly condensed‐history models. However, general, such models suitable for macroscopic volumes and electron energies above a few hundred volts. We recently developed, Geant4‐DNA extension Geant4 toolkit, discrete physics transport gold which...
Gold nanoparticle (GNP) boosted radiation therapy can enhance the biological effectiveness of treatments by increasing quantity direct and indirect radiation-induced cellular damage. As physical effects GNP radiotherapy occur across energy scales that descend down to 10 eV, Monte Carlo simulations require discrete physics models these very low energies in order avoid underestimating absorbed dose secondary particle generation. Discrete for electron transportation eV have been implemented...
This paper presents the influence of electron elastic scattering models, thermalization and chemical parameters on Geant4-DNA simulations liquid water radiolysis under mega-electron-volt irradiation. The radiochemical yields are simulated using a new example. In particular, model recently developed is presented as well improved models. chemistry constructor another Monte Carlo track structure code also described. results calculated these different models compared with each other experimental...
Accurately modeling the radiobiological mechanisms responsible for induction of DNA damage remains a major scientific challenge, particularly understanding effects low doses ionizing radiation on living beings, such as carcinogenesis. A computational approach based Monte Carlo technique to simulate track structures in biological medium is currently most reliable method calculating early induced by DNA, primary cellular target effects. The Geant4-DNA toolkit can not only physical, but also...
Purpose:Track structure Monte Carlo (MC) codes have achieved successful outcomes in the quantitative investigation of radiation-induced initial DNA damage. The aim present study is to extend a Geant4-DNA radiobiological application by incorporating feature allowing for prediction rejoining kinetics and corresponding cell surviving fraction along time after irradiation, Chinese hamster V79 line, which one most popular widely investigated lines radiobiology.Methods:We implemented Two-Lesion...
Two numerical solutions of the Boltzmann equation are developed and applied to calculations swarm time-of-flight parameters in molecular model gases. It is shown that two methods not only give near similar results but good agreement with carried out by some other authors for same situations. Errors already pointed works confirmed need using high-order solution stressed.
This paper, the third in a series of three, describes work carried context Plasma Data Exchange Project Gaseous Electronics Conference (PDEP-GEC) to compare electron collision cross-sections sets from ground-state, noble gases atoms and check their consistency with measured swarm parameters. Such is minimum requirement if cross-section data are be used for modelling low-temperature plasmas. In this we present intercomparisons independently compiled neutral Kr Xe presently available on LXCat...
The mechanistic Monte Carlo modeling of biological effects ionising radiation at sub-cellular and DNA scale requires the accurate simulation track structures in medium, commonly approximated as liquid water. formalism microdosimetry allows one to describe quantitatively spatial distribution energy deposition irradiated which is known relate deleterious cellular targets. Geant4-DNA extension Geant4 open-source general-purpose toolkit has been recently evaluated for spectra, allowing,...