A5027801501- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Eosinophilic Esophagitis
- Gastroesophageal reflux and treatments
- Lung Cancer Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Pancreatic and Hepatic Oncology Research
- Dysphagia Assessment and Management
- Helicobacter pylori-related gastroenterology studies
- Gallbladder and Bile Duct Disorders
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Intestinal Malrotation and Obstruction Disorders
- Eosinophilic Disorders and Syndromes
- Multiple and Secondary Primary Cancers
- Gastrointestinal motility and disorders
- Diverticular Disease and Complications
- Pediatric Hepatobiliary Diseases and Treatments
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Gastrointestinal Bleeding Diagnosis and Treatment
- Cancer Cells and Metastasis
- Diabetes Treatment and Management
- Child Nutrition and Feeding Issues
Czech Academy of Sciences, Institute of Physiology
2019-2022
Institute of Clinical and Experimental Medicine
2014-2022
Charles University
2019-2022
Zamorano Pan-American Agricultural School
2015
Proton pump inhibitor-responsive esophageal eosinophilia (PPI-REE) is diagnosed in at least one-third of patients with suspected eosinophilic esophagitis (EoE). We aimed to evaluate the durability and factors influencing long-term efficacy PPI therapy.Retrospective multicenter cohort study PPI-REE who had 12 months follow-up. therapy was tapered lowest dose, which maintained clinical remission. Primary outcomes were proportion loss histological response (<15 eos/HPF) predictors response....
Several studies have reported partial recovery of peristalsis in patients with achalasia after myotomy. The aim our study is to analyze esophageal motility patterns peroral endoscopic myotomy (POEM) and assess the potential predictors clinical impact peristaltic recovery.We performed a retrospective analysis prospectively collected data consecutive undergoing POEM at tertiary center. High-resolution manometry (HRM) prior were reviewed Chicago classification was applied.A total 237 analyzed....
Probe-based confocal laser endomicroscopy (pCLE) provides real-time microscopic visualisation. Our aim was to compare the diagnostic accuracy of pCLE with standard biopsies in patients visible oesophageal or gastric lesions.This a single-centre, prospective, pathologist-blinded study. Patients underwent high-resolution endoscopy, and lesions were examined by followed biopsies. A definitive diagnosis determined from resection specimen. Main outcomes overall accuracy, sensitivity, specificity...
Background & Aims: Radiofrequency ablation (RFA) with/without endoscopic resection (ER) is the standard treatment modality for Barrett‘s esophagus (BE) related neoplasia (BORN). The main aim of this study was to assess long-term outcomes RFA in patients with BORN. Methods: We retrospectively analyzed prospectively collected data from Czech national database. Main were: complete remission (CR-N), intestinal metaplasia (CR-IM), recurrence both and IM, safety. Results: From a total 170 BORN...
Introduction: Endoscopic pyloromyotomy (G-POEM) is an emerging therapeutic method for the treatment of gastroparesis (GP). So far, only limited case-series suggesting its effectivity have been published. The aim our study was to assess G-POEM in patients with refractory GP. Methods: Consecutive severe and GP were offered procedure. An abnormal gastric emptying (GES) necessary inclusion. main outcome success defined as a decrease total GSCI symptom score by at least 40% from baseline 3, 6, 12...
Introduction: An accurate histopathological diagnosis of indeterminate biliary strictures and pancreatic lesions is challenging because insufficient quality tissue specimen taken during ERCP (brush cytology), cholangioscopy (biopsies) or endosonography (EUS, FNAB). Confocal laser endomicroscopy (CLE) allows virtual with the potential to either replace increase diagnostic yield standard in patients presenting lesions. The aims our prospective pilot study were to: 1. Assess histopathology...
Background and Aims: Patients after endoscopic treatment of Barrett‘s esophagus (BE) related neoplasia (BORN) should enter surveillance with biopsies to detect persistent or recurrent intestinal metaplasia (IM). Probe-based confocal laser endomicroscopy (pCLE) serves as a virtual biopsy could replace standard biopsies. However, the role pCLE in patients BORN has not been systematically assessed. The aim this study was compare detecting persistent/recurrent IM/neoplasia.
 Methods: A...
Aims G-POEM is an emerging method for treatment of gastroparesis. Safe mucosal closure necessary to avoid adverse events. The aim this prospective study was compare the effectivity two methods: clips (ResolutionTM or InstinctTM) and endoscopic suturing (ES, Apollo OverStitchTM) in patients undergoing G-POEM.
Esophageal achalasia is a primary motility disorder. Although the exact pathogenesis unknown, autoimmune, and neurodegenerative processes seem to be involved similarly and/or demyelinating disorders (NDDs). We hypothesized that prevalence of NDD may higher among patients with vice versa as background pathogenetic mechanisms are similar.This was prospective, comparative questionnaire-based study. Patients were enrolled. Selected thoroughly examined by neurologist selected gastroenterologist...