A5063625352- Esophageal and GI Pathology
- Gastroesophageal reflux and treatments
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Eosinophilic Esophagitis
- Gastrointestinal disorders and treatments
- Dysphagia Assessment and Management
- Helicobacter pylori-related gastroenterology studies
- Lung Cancer Diagnosis and Treatment
- Gastrointestinal motility and disorders
- Metastasis and carcinoma case studies
- Intestinal Malrotation and Obstruction Disorders
- Tracheal and airway disorders
- Gastrointestinal Tumor Research and Treatment
- Gallbladder and Bile Duct Disorders
- Celiac Disease Research and Management
- Multiple and Secondary Primary Cancers
- Pancreatic and Hepatic Oncology Research
- Birth, Development, and Health
- Carbohydrate Chemistry and Synthesis
- Colorectal Cancer Screening and Detection
- Hormonal Regulation and Hypertension
- Abdominal vascular conditions and treatments
- Diverticular Disease and Complications
- Gastrointestinal Bleeding Diagnosis and Treatment
Military University Hospital Prague
2023-2025
Institute of Clinical and Experimental Medicine
2015-2023
Charles University
2008-2022
Czech Academy of Sciences, Institute of Physiology
2020-2022
Generi Biotech (Czechia)
2008-2009
Objective Endoscopic pyloromyotomy (G-POEM) is a minimally invasive treatment option with promising uncontrolled outcome results in patients gastroparesis. Design In this prospective randomised trial, we compared G-POEM sham procedure severe The primary was the proportion of success (defined as decrease Gastroparesis Cardinal Symptom Index (GCSI) by at least 50%) 6 months. Patients to group persistent symptoms were offered cross-over G-POEM. Results enrolment stopped after interim analysis...
Breast cancer resistance protein (BCRP/ABCG2) is a member of the ATP-binding cassette transporter family that recognizes variety chemically unrelated compounds. Its expression has been revealed in many mammal tissues, including placenta. The purpose this study was to describe its role transplacental pharmacokinetics using rat placental HRP-1 cell line and dually perfused In cells, Bcrp, but not P-glycoprotein, at mRNA levels. Cell accumulation studies confirmed Bcrp-dependent uptake BODIPY...
Main Recommendations Peroral endoscopic myotomy (POEM) is an advanced procedure that has become a first-line treatment for esophageal achalasia and other spastic disorders. Structured training essential to optimize the outcomes of this technique. The European Society Gastrointestinal Endoscopy (ESGE) recognized need formalize enhance in POEM. This Position Statement presents results systematic review literature formal Delphi process, providing recommendations optimal program POEM aims...
Several studies have reported partial recovery of peristalsis in patients with achalasia after myotomy. The aim our study is to analyze esophageal motility patterns peroral endoscopic myotomy (POEM) and assess the potential predictors clinical impact peristaltic recovery.We performed a retrospective analysis prospectively collected data consecutive undergoing POEM at tertiary center. High-resolution manometry (HRM) prior were reviewed Chicago classification was applied.A total 237 analyzed....
Probe-based confocal laser endomicroscopy (pCLE) provides real-time microscopic visualisation. Our aim was to compare the diagnostic accuracy of pCLE with standard biopsies in patients visible oesophageal or gastric lesions.This a single-centre, prospective, pathologist-blinded study. Patients underwent high-resolution endoscopy, and lesions were examined by followed biopsies. A definitive diagnosis determined from resection specimen. Main outcomes overall accuracy, sensitivity, specificity...
Helicobacter pylori belongs to the most common bacterial infections worldwide; despite its decreasing prevalence during past four decades (currently ~ 40–50%), it is more prevalent in developing countries compared developed ones. Intensive research of chronic infection clarified pathogenesis several gastric and extragastric diseases, including different cancers. This review pointed out role malignancies. Chronic an etiological factor non-cardia cancer cases low-grade MALT lymphoma stomach....
Achalasia is a primary oesophageal motility disorder. Although aetiology remains mainly unknown, genetic risk variant, rs28688207 in HLA-DQB1, showed strong achalasia association suggesting involvement of immune-mediated processes the pathogenesis. High-resolution manometry recognises three types achalasia. The aim our study was to perform first genotype-phenotype analysis investigating frequency across high-resolution subtypes.
Introduction: Endoscopic pyloromyotomy (G-POEM) is an emerging therapeutic method for the treatment of gastroparesis (GP). So far, only limited case-series suggesting its effectivity have been published. The aim our study was to assess G-POEM in patients with refractory GP. Methods: Consecutive severe and GP were offered procedure. An abnormal gastric emptying (GES) necessary inclusion. main outcome success defined as a decrease total GSCI symptom score by at least 40% from baseline 3, 6, 12...
Introduction: An accurate histopathological diagnosis of indeterminate biliary strictures and pancreatic lesions is challenging because insufficient quality tissue specimen taken during ERCP (brush cytology), cholangioscopy (biopsies) or endosonography (EUS, FNAB). Confocal laser endomicroscopy (CLE) allows virtual with the potential to either replace increase diagnostic yield standard in patients presenting lesions. The aims our prospective pilot study were to: 1. Assess histopathology...
Background and Aims: Patients after endoscopic treatment of Barrett‘s esophagus (BE) related neoplasia (BORN) should enter surveillance with biopsies to detect persistent or recurrent intestinal metaplasia (IM). Probe-based confocal laser endomicroscopy (pCLE) serves as a virtual biopsy could replace standard biopsies. However, the role pCLE in patients BORN has not been systematically assessed. The aim this study was compare detecting persistent/recurrent IM/neoplasia.
 Methods: A...
Abstract Background and study aims Circular ESD (CESD) is a treatment option for patients with extensive early esophageal cancer. Its major drawback the development of stricture. Stenting may represent an attractive prevention strategy. We designed experimental to assess effect stents covered acellular biomatrix (AB) drug-eluting stent. Materials methods Thirty-five 35 pigs underwent CESD were randomized into six groups: G1 (control), G2 (SEMS), G3 (SEMS + AB), G4 AB steroid-eluting layer),...