A5102739103- Gastroesophageal reflux and treatments
- Esophageal and GI Pathology
- Multiple Sclerosis Research Studies
- Dysphagia Assessment and Management
- Gallbladder and Bile Duct Disorders
- Intestinal Malrotation and Obstruction Disorders
- Quantum and electron transport phenomena
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastrointestinal motility and disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Advanced Neuroimaging Techniques and Applications
- Quantum Information and Cryptography
- Helicobacter pylori-related gastroenterology studies
- Quantum Computing Algorithms and Architecture
- Gastrointestinal disorders and treatments
- Gut microbiota and health
- Education, Psychology, and Social Research
- Quantum-Dot Cellular Automata
- Clostridium difficile and Clostridium perfringens research
- Rheumatoid Arthritis Research and Therapies
- Intestinal and Peritoneal Adhesions
- COVID-19 Clinical Research Studies
- Wound Healing and Treatments
- Pathogenesis and Treatment of Hiccups
- Gynecological conditions and treatments
Institute of Clinical and Experimental Medicine
2021-2025
National Institute of Mental Health
2021-2022
Czech Technical University in Prague
2019-2022
Czech Academy of Sciences, Institute of Computer Science
2022
Czech Academy of Sciences
2022
Palacký University Olomouc
2013-2020
University Hospital Olomouc
2020
Objective Endoscopic pyloromyotomy (G-POEM) is a minimally invasive treatment option with promising uncontrolled outcome results in patients gastroparesis. Design In this prospective randomised trial, we compared G-POEM sham procedure severe The primary was the proportion of success (defined as decrease Gastroparesis Cardinal Symptom Index (GCSI) by at least 50%) 6 months. Patients to group persistent symptoms were offered cross-over G-POEM. Results enrolment stopped after interim analysis...
Although women with severe symptomatic aortic stenosis have more complications than men when undergoing surgical valve replacement, they are under-represented in clinical trials. The Randomized researcH womEn all comers wIth Aortic (RHEIA) trial investigates the balance of benefits and risks transcatheter implantation (TAVI) vs. surgery women. Women were randomized 1:1 to transfemoral TAVI a balloon-expandable or surgery. primary composite endpoint was death, stroke, (valve, procedure heart...
Abstract The human brain represents a complex computational system, the function and structure of which may be measured using various neuroimaging techniques focusing on separate properties tissue activity. We capture organization white matter fibers acquired by diffusion-weighted imaging probabilistic diffusion tractography. By segmenting results tractography into larger anatomical units, it is possible to draw inferences about structural relationships between these parts system. This...
Background Endoluminal radiofrequency ablation (RFA) has been promoted as palliative treatment for patients with cholangiocarcinoma (CCA) and pancreatic ductal adenocarcinoma (PDAC) in order to improve biliary drainage eventually prolong survival. No high level evidence is, however, available on this technique. Design In randomised controlled study, we compared endoluminal RFA plus stenting alone (control group) malignant obstruction; metal stents were primarily placed. Primary outcome was...
Background and Aims: Ulcerative colitis (UC) is a chronic inflammatory disease. Fecal microbial transplantation (FMT) promising alternative treatment. Methods: This multicenter, open-label, noninferiority trial randomized patients with active left-sided UC (Mayo score 4–10) equally to FMT or 5-aminosalicylic acid (5-ASA) enemas. enemas were administered five times in the first week then once weekly for 5 weeks. 5-ASA daily 2 weeks every other day. The primary study endpoint was clinical...
Abstract Background Albuminuria, an important marker of decreased kidney function in chronic disease (CKD), is not routinely used for CKD detection or proteinuria appearance. Its relationships with biochemical parameters and blood pressure dogs are poorly understood. Objectives This study aimed to evaluate the relationship albuminuria various markers, its correlation urinary protein creatinine ratio (UPC), hypertension early stages CKD. It also sought determine usability albumin (UAC)...
Only limited epidemiological data exist from national or international prospective multicentre registries covering the whole spectrum of cardiogenic shock (CS) aetiologies. CZECH-SHOCK was a observational study conducted in 15 main tertiary care centres Czechia over 12-month period March 2023 to February 2024. A total 418 patients with median age 70 (IQR 59-76) years were enrolled. The majority male (69.6%). newly developed heart failure observed 76.8% patients, and acute myocardial...
Diabetic foot (DF), especially DF ulcers (DFUs) are a relatively frequent and financially burdensome late-stage complication of diabetes. However, data on the costs podiatric care in Czech Republic scarce. The aim this prospective multicenter study was to determine total associated with long-term selected clinics across Republic. A 119 patients DFUs (mean age 68 ± 11 years, diabetes duration 19 HbA1c level 62 14 mmol/mol, composite WIfI score 3 2, 33 % had new DFUs, 37 previous amputations,...
Several studies have reported partial recovery of peristalsis in patients with achalasia after myotomy. The aim our study is to analyze esophageal motility patterns peroral endoscopic myotomy (POEM) and assess the potential predictors clinical impact peristaltic recovery.We performed a retrospective analysis prospectively collected data consecutive undergoing POEM at tertiary center. High-resolution manometry (HRM) prior were reviewed Chicago classification was applied.A total 237 analyzed....
Radiofrequency ablation (RFA) is a mini-invasive loco-regional technique that increasingly being used as palliative treatment for pancreatic cancer and cholangiocarcinoma. Ablation-triggered immune system stimulation has been proposed mechanism behind the systemic effects of RFA. The aim our study was to investigate response endoluminal biliary Peripheral blood samples were collected from patients with cholangiocarcinoma randomised receive radiofrequency + stent (19 patients) or only (21...
Objective: When Sativex THC:CBD cannabinoid-based oromucosal spray was first approved as a prescription medicine for multiple sclerosis (MS) spasticity, there some concern about its possible long-term impact on cognition and mood.The objective of this study therefore to assess the cognitive function mood in MS patients with spasticity.Methods: 121 were randomly assigned or placebo double-blind manner.Patients selfadministered treatment daily 48 weeks while maintaining anti-spasticity...
We present an alternative definition of discrete-time coined quantum walks convenient for capturing a rather broad spectrum walker's behavior on arbitrary graphs. It includes and covers both the geometry possible positions with interconnecting links prescribed rule in which directions walker will move at each vertex. While former allows analysis inhomogeneous graphs vertices varying degree, latter offers us to choose, investigate, compare different shift operators. The synthesis key...
Quantum walks are accepted as a generic model for quantum transport. The character of the transport crucially depends on properties walk like its geometry and driving coin. We demonstrate that increasing distance between source target or adding redundant branches to actual graph may surprisingly result in significant enhancement efficiency. explain analytically observed nonclassical effects using concept trapped states several intriguing geometries, including ladder graph, Cayley tree, modifications.
BACKGROUND: Changes of white matter integrity in people with multiple sclerosis (MS) were documented following mainly motor/skill acquisitions physical therapy, while neuroproprioceptive "facilitation, inhibition" (neurofacilitation) only by two pilot studies. Neurofacilitation has potential to induce changes due the possibility interfering neuronal tactility threshold. However stronger evidence is missing.AIM: This study investigates whether neurofacilitation (three therapy types) and if...
Quantum walks exhibit properties without classical analogues. One of those is the phenomenon asymptotic trapping---there can be nonzero probability quantum walker being localized in a finite part underlying graph indefinitely even though locally all directions movement are assigned amplitudes at each step. We study with flip-flop shift operator and Grover coin, where this effect has been identified previously. For version walk further modified by random dynamical disruption (percolated...
Aims Endoscopic pyloromyotomy (G-POEM) has a promising short-term results in patients with gastroparesis (GP). We aimed to assess its long-term efficacy refractory GP.