Reproductive toxicity is a major challenge associated with aluminum (Al) exposure. No studies have evaluated the possible effects of curcumin (CUR) on Al-induced reproductive dysfunction. Therefore, this study investigated CUR treatment damage.In experimental study, 40 male Wistar rats were allocated to five groups (n=8) based they received: no (control), solvent [dimethyl sulfoxide (DMSO) or distilled water], 10 mg/kg body weight (BW), Al chloride BW, and CUR+Al (10 BW/each alone)....

Polycystic ovary syndrome (PCOS) is associated with low-quality oocytes. The aim of the present study was to investigate effects metformin (MET), N-acetylcysteine (NAC) and their combination on follicular fluid parameters, oocytes embryo quality in PCOS patients. A prospective randomised placebo-controlled pilot 60 Iranian women (aged 25–35 years) undergoing intracytoplasmic sperm injection (ICSI) designed. Women were divided into four groups (n = 15 each): (1) an MET, administered 1500 mg...

Aluminum is recognized as a public health concern because of its potential toxic effects on human health. Therefore, the present experiment was undertaken to determine effectiveness curcumin (CUR) in reducing hepatotoxicity induced by aluminum chloride (AlCl3) animals. In this experimental study, forty male rats were allocated five groups (N = 8), viz. no treatment (control), solvent (DMSO or distilled water), CUR (10 mg/kg B.W.), AlCl3 and CUR+AlCl3 (each with 10 B.W.). Treatments performed...

The study has aimed to investigate the effect of Quercetin, as a potent antioxidant, on preventing negative effects freezing process sperm quality patients with Asthenospermia. Semen sample from 25 was randomly divided into three groups; fresh, control and Quercetin (50 μM). Seven days after freezing, samples were thawed at ambient temperature. Total motility, progressive normal morphology, viability DNA integrity evaluated according WHO criteria, Papanicolaou, eosin- nigrosine acridine...

Background: Coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may lead to infertility of men. Objectives: This study aimed investigate impact COVID-19 infection on sperm parameters and reproductive hormones in fertile Methods: A total 100 males were selected divided into two groups: (1) patients convalescence (patients suffering from pharyngeal swab accordance with reverse-transcription polymerase chain reaction [RT-PCR]...

In this study, the influence of myoinositol (MYO) as an antioxidant on inhibition negative impacts cryopreservation sperm quality in men with Asthenospermia was investigated. prospective each semen sample from 25 cases separated into three groups: Fresh, Control (with freezing medium), Myoinositol (2 mg/ml). According to World Health Organization criteria (WHO) (2010), total motility, progressive viability, normal morphology, and DNA integrity were assessed. addition, hypo-osmotic swelling...

Paracrine disruption of growth factors in women with polycystic ovarian syndrome (PCOS) results production low quality oocyte, especially following ovulation induction. The aim this study was to investigate the effects metformin (MET), N-acetylcysteine (NAC) and their combination on hormonal levels expression profile GDF-9, BMP-15 c-kit, as hallmarks oocyte quality, PCOS patients.This prospective randomized, double-blind, placebo controlled trial aims MET, NAC (MET+NAC) c-kit mRNA oocytes...

Genetic factors are significantly have important role in the etiology of polycystic ovary syndrome (PCOS). This study examined possible relation rs1484215 and rs6495096 polymorphisms CYP11A1 gene Iranian women with PCOS.The population case-control research included 100 presenting PCOS as a control group who were referred to Infertility Center Qom, Iran. The genotypes detected tetra-ARMS PCR method. independent segregation alleles was tested for Hardy-Weinberg equilibrium (HWE). Differences...

Silver nanoparticles (SNPs) can pass from the cell membrane and testicular blood barrier due to their small size, by increasing oxidative stress they cause disorder in male reproductive system. Kombucha is a traditional fermented drink with detoxification potent antioxidant properties. We aimed examine protective effect of against damages SNPs on testis tissue. In this experimental study, NMRI mice were randomly separated into four groups (n = 6), namely control (distilled water), (500...

In infertile men, reduced expression of heat shock protein A2 (HSPA2) is related to sperm quality and function. The present study has aimed investigate the effects N-acetyl-cysteine (NAC) supplementation on (HSPA2). this in continuation previous study, semen samples from 50 astheno-terato-zoospermic men who have received NAC (600 mg/day) orally for three months were evaluated HSPA2 using RT-PCR, Western blot analysis. addition, these individuals assessed parameters, DNA fragmentation...

Owing to chitosan properties such as biocompatibility and antimicrobial activities, several applications in biomedical field, some physicochemical anti-bacterial properties, the level of from three species American cockroach, Periplaneta americana (Dictyoptera: Blattidae), German Blattella germanica Ectobiidae) Mealworm beetle, Tenebrio molitor (Coleoptera: Tenebrionidae) were investigated.The cuticle adults derived specimens was dried grounded. The powders demineralized well deproteinized...

<title>Abstract</title> Purpose The research investigated the capacity of Myo-inositol (MI) in order that it improves biochemical markers serum and follicular fluid, ultimately, intracytoplasmic sperm injection (ICSI) outcomes women with PCOS. Methods Sixty infertile patients PCOS who were undergoing ovulation induction for ICSI, randomly divided to two groups. MI group received 2000 mg + 1 folic acid twice a day 6 weeks starting ICSI cycle. For same period, control placebo containing only...