Lei Yang

ORCID: 0000-0003-4851-8872
Publications
Citations
Views
---
Saved
---
About
Contact & Profiles
Research Areas
  • Biofuel production and bioconversion
  • Microbial Metabolic Engineering and Bioproduction
  • Fungal and yeast genetics research
  • Enzyme Catalysis and Immobilization
  • Insect-Plant Interactions and Control
  • Structural Load-Bearing Analysis
  • Pharmacological Effects of Natural Compounds
  • Structural Analysis and Optimization
  • Insect Pest Control Strategies
  • Wood Treatment and Properties
  • Plant tissue culture and regeneration
  • Fungal Biology and Applications
  • CRISPR and Genetic Engineering
  • Insect Resistance and Genetics
  • Food Quality and Safety Studies
  • Microbial Metabolites in Food Biotechnology
  • Viral Infections and Immunology Research
  • Bacterial biofilms and quorum sensing
  • Biomedical and Engineering Education
  • Heavy metals in environment
  • Advanced Glycation End Products research
  • Advanced Chemical Sensor Technologies
  • Lignin and Wood Chemistry
  • Catalysis for Biomass Conversion
  • Coal and Its By-products

Anhui Normal University
2024

Jiangsu Academy of Agricultural Sciences
2022-2024

Institute of Plant Protection
2022-2024

Nanjing Agricultural University
2017-2024

Shanghai Institute of Technology
2024

Central South University of Forestry and Technology
2011-2023

Central South University
2023

Henan Provincial People's Hospital
2023

Henan University
2023

Zhengzhou University
2023

This study analysed the effect of different ageing time (0, 12, 24, 48, and 72 h) on flavour profiles Nanjing water-boiled salted duck (WSD) using headspace-gas chromatography-ion mobility spectrometry (HS-GC-IMS). Physicochemical indices such as water content thiobarbituric acid reactive substances (TBARs) were also detected. The HS-GC-IMS identified 47 volatile organic compounds, including their monomers dimers. Among them, 1-octen-3-ol, n-nonanal, 2-heptanone, iso-propyl acetate, ethyl...

10.1016/j.lwt.2021.112870 article EN cc-by-nc-nd LWT 2021-11-26

Background: Familial hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disease and typically caused by mutations in genes encoding sarcomeric proteins that regulate contractility. HCM manifestations include left ventricular hypertrophy heart failure, arrythmias, sudden death. How dysregulated force production sensed leads to pathological remodeling remains poorly understood HCM, thereby inhibiting efficient development of new therapeutics. Methods: Our discovery was...

10.1161/circulationaha.121.056265 article EN Circulation 2022-04-06

There is an endemic cardiomyopathy currently occurring in China, termed, Keshan disease (KD). The authors previously compared mitochondrial‑associated gene expression profiles of peripheral blood mononuclear cells (PBMCs) derived from KD patients and normal controls, using mitochondria‑focused cDNA microarray technology. results detected upregulation the enzyme‑associated CYP1A1 gene, (ratios ≥2.0). aryl hydrocarbon receptor (AhR) regulates numerous cytochrome P450 (CYP) genes including...

10.3892/mmr.2017.6580 article EN cc-by-nc-nd Molecular Medicine Reports 2017-01-01

Abstract Background Succinic acid has great potential to be a new bio-based building block for deriving number of value-added chemicals in industry. Bio-based succinic production from renewable biomass can provide feasible approach partially alleviate the dependence global manufacturing on petroleum refinery. To improve economics biological processes, we attempted explore possible solutions with fungal cell platform. In this study, Aspergillus niger , well-known industrial organism organic...

10.1186/s13068-020-01850-5 article EN cc-by Biotechnology for Biofuels 2020-12-01

Aspergillus carbonarius has potential as a cell factory for the production of different organic acids. At pH 5.5, A.carbonarius accumulates high amounts gluconic acid when it grows on glucose based medium whereas at low pH, produces citric acid. The conversion to is carried out by secretion enzyme, oxidase. In this work, gene encoding oxidase was identified and deleted from A. with aim changing carbon flux towards other effect genetic engineering examined testing deficient (Δgox) mutants...

10.1186/s13568-014-0054-7 article EN cc-by AMB Express 2014-08-14

C4-dicarboxylic acids, including malic acid, fumaric acid and succinic are valuable organic acids that can be produced secreted by a number of microorganisms. Previous studies on production Aspergillus carbonarius, which is capable producing high amounts citric from varieties carbon sources, have revealed its potential as fungal cell factory. Earlier attempts to reroute into been with limited success.In this study, glucose oxidase deficient strain A. carbonarius was used the parental...

10.1186/s12934-017-0660-6 article EN cc-by Microbial Cell Factories 2017-03-14

Various plant species contain terpene secondary metabolites, which disrupt insect growth and development by affecting the activity of juvenile hormone-degrading enzymes, hormone (JH) titers maintained in insects. Nerolidol, a natural sesquiterpenol belonging to terpenoid group, exhibits structural similarities JHs. However, impact nerolidol on development, as well its underlying molecular mechanism, remains unclear. Here, effects Spodoptera exigua were investigated under treatment at various...

10.3390/ijms241713330 article EN International Journal of Molecular Sciences 2023-08-28

Glulam beams connected with steel splints and bolts (GBSBs) are subjected to cyclic reciprocating dynamic loads in practice, which eventually leads damage accumulation structure failure. In order promote the development of GBSBs, an experimental study was carried out, theoretical analysis fatigue behavior GBSBs conducted. Three static load test six were designed fabricated, taking into account different stress levels limit loads. Theoretical data, linear regression analysis, electron...

10.3390/buildings13051218 article EN cc-by Buildings 2023-05-05

Abstract Aspergillus carbonarius has a potential as cell factory for production of various organic acids. In this study, the acid profile A. was investigated under different cultivation conditions. Moreover, two heterologous genes, pepck and ppc, which encode phosphoenolpyruvate carboxykinase in Actinobacillus succinogenes carboxylase Escherichia coli, were inserted individually combination to enhance carbon flux toward reductive TCA branch. Results transcription analysis measurement enzyme...

10.1007/s10295-015-1688-4 article EN cc-by Journal of Industrial Microbiology & Biotechnology 2015-09-24

Introduction Paraclostridium bifermentans is responsible for spoilage properties in vacuum-packaged meat. Ordinary heat treatment techniques are ineffective to control the extremely heat-resistant spores of P. . Therefore, finding a new strategy prevent contamination meat challenging. Methods In this study, was isolated from chicken, and inhibitory effects licorice extract on germination outgrowth spores, as well key bioactive components involved inhibiting spore activity, were investigated....

10.3389/fmicb.2022.1076144 article EN cc-by Frontiers in Microbiology 2022-12-02

Abstract Background In filamentous fungi, transport of organic acids across the mitochondrial membrane is facilitated by active via shuttle proteins. These transporters may transfer different while taking others opposite direction. Aspergillus niger , accumulation malate in cytosol can trigger production citric acid exchange and citrate membrane. Several were recently studied A. showing their effects on production. Results this work, we another producing fungus, carbonarius identified...

10.1186/s12896-019-0572-0 article EN cc-by BMC Biotechnology 2019-11-04

Significant research progress has recently been made on establishing the roles of tps46 in rice defense. (E)-β-farnesene (Eβf) is a major product activity but its physiological functions and potential mechanisms against Chilo suppressalis have not yet clarified. In present study, C. larvae were artificially fed diet containing 0.8 g/kg Eβf performance was evaluated. response to treatment, average 2nd instar duration significantly increased from 4.78 d 6.31 while that 3rd 5.70 8.00 compared...

10.3389/fphys.2022.904482 article EN cc-by Frontiers in Physiology 2022-05-30

The (E)-β-farnesene (EβF) is one of the most important secondary metabolites in some plants and provides indirect defense against aphids. However, direct effect EβF pests still unclear. In this study, various concentrations (0.16, 0.8, 4 g/kg) were provided an artificial diet to determine effects on Spodoptera exigua. results showed that containing g/kg reduced final survival S. exigua larvae per female fecundity adults significantly when compared with CK SC controls (p < 0.05), then...

10.3389/fpls.2022.863626 article EN cc-by Frontiers in Plant Science 2022-08-23

Herbivores harbor gut microbes that affect their development and contribute to nutrition, reproduction, survival. Plant defenses could target the herbivore's beneficial microbes, but this has not been well studied in rice. In context, we identified a rice terpene synthase gene, Os04g0341500. It was strongly induced after feeding by striped stem borers (SSB,

10.1021/acs.jafc.4c02074 article EN Journal of Agricultural and Food Chemistry 2024-10-17

Sepsis is a life-threatening organ dysfunction syndrome that leads to the massive death of immune cells. Long non-coding RNAs (lncRNAs) have been reported exert key regulatory roles in However, it unclear how lncRNAs regulate survival cells occurrence and development sepsis.In this study, we used blood whole transcriptome sequencing data (RNA-seq) from normal controls (Hlty) patients with uncomplicated infection (Inf1 P), sepsis (Seps septic shock (Shock investigate fraction changes cell...

10.3389/fimmu.2023.1026086 article EN cc-by Frontiers in Immunology 2023-02-02

Abstract Sunflower stalk (SS) and its alkaline hydrolysis residue (SHR) were characterized by means of chemical component analysis, Fourier Transform infrared (FT‐IR) spectrometer scanning electron microscope (SEM), their pyrolysis behaviors investigated a thermal gravimetric (TG) analyzer, self‐designed apparatus pyrolysis‐chromatograph/mass (py‐GC/MS). The results showed that the components, structures surface morphologies SS SHR are notably different as result mild delignification during...

10.1002/apj.2015 article EN Asia-Pacific Journal of Chemical Engineering 2016-05-12
Coming Soon ...