A5006829952- Antifungal resistance and susceptibility
- Hepatitis C virus research
- Protist diversity and phylogeny
- Bacterial biofilms and quorum sensing
- Liver Disease Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI)
2021
Friedrich Schiller University Jena
2021
MRC University of Glasgow Centre for Virus Research
2019
Hepatitis C virus (HCV) is a highly variable pathogen that frequently establishes chronic infection. This genetic variability affected by the adaptive immune response but contribution of other host factors unclear. Here, we examined role played interferon lambda-4 (IFN-λ4) on HCV diversity; IFN-λ4 plays crucial in spontaneous clearance or establishment chronicity following acute We performed viral genome-wide association studies using human and data from 485 patients white ancestry infected...
Predatory interactions among microbes are major evolutionary driving forces for biodiversity. The fungivorous amoeba Protostelium aurantium has a wide fungal food spectrum including foremost pathogenic members of the genus Candida. Here we show that upon phagocytic ingestion by amoeba, Candida parapsilosis is confronted with an oxidative burst and undergoes lysis within minutes processing in acidified phagolysosomes. On side, functional genomic approach identified copper redox homeostasis as...