A5013590445- Malaria Research and Control
- Global Maternal and Child Health
- Travel-related health issues
- Mosquito-borne diseases and control
- Pregnancy and preeclampsia studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Maternal and Perinatal Health Interventions
- Maternal and fetal healthcare
- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Parasites and Host Interactions
- Iron Metabolism and Disorders
- Hepatitis Viruses Studies and Epidemiology
- Prenatal Screening and Diagnostics
- Infectious Encephalopathies and Encephalitis
- Pleural and Pulmonary Diseases
- Vector-borne infectious diseases
- Infections and bacterial resistance
- Helminth infection and control
- Cavitation Phenomena in Pumps
- Pregnancy and Medication Impact
- Drug-Induced Hepatotoxicity and Protection
- Assisted Reproductive Technology and Twin Pregnancy
- Organ Donation and Transplantation
- Bacterial Identification and Susceptibility Testing
Shoklo Malaria Research Unit
2008-2019
Mahidol University
2008-2019
Mahidol Oxford Tropical Medicine Research Unit
2008-2019
Amsterdam UMC Location University of Amsterdam
2010-2013
University of Amsterdam
2013
University Medical Center Utrecht
2003-2010
Churchill Hospital
2008-2010
Weatherford College
2010
The effects of malaria and its treatment in the first trimester pregnancy remain an area concern. We aimed to assess outcome malaria-exposed malaria-unexposed first-trimester pregnancies women from Thai-Burmese border compare outcomes after chloroquine-based, quinine-based, or artemisinin-based treatments.We analysed all antenatal records attending Shoklo Malaria Research Unit clinics May 12, 1986, Oct 31, 2010. Women without were compared with those who had a single episode trimester....
Background The Shoklo Malaria Research Unit has been working on the Thai–Myanmar border for 25 y providing early diagnosis and treatment (EDT) of malaria. Transmission Plasmodium falciparum declined, but resistance to artesunate emerged. We expanded malaria activities through EDT evaluated impact over a 12-y period. Methods Findings Between 1 October 1999 30 September 2011, increased number cross-border (Myanmar side) health facilities from two 11 recorded consultations. Changes in incidence...
Introduction Maternal mortality is high in developing countries, but there are few data high-risk groups such as migrants and refugees malaria-endemic areas. Trends maternal were followed over 25 years antenatal clinics prospectively established an area with low seasonal transmission on the north-western border of Thailand. Methods Findings All medical records from women who attended Shoklo Malaria Research Unit 12th May 1986 to 31st December 2010 reviewed, death analyzed for causality....
Abstract Objectives Ultrasound examination of the fetus is a powerful tool for assessing gestational age and detecting obstetric problems but rarely available in developing countries. The aim this study was to assess intraobserver interobserver agreement fetal biometry by locally trained health workers refugee camp on Thai–Burmese border. Methods One expatriate doctor four local participated study, which included examinations performed every fifth pregnant woman with singleton pregnancy...
Background Deworming is recommended by the WHO in girls and pregnant lactating women to reduce anaemia areas where hookworm are common. There conflicting evidence on harm benefits of intestinal geohelminth infections incidence severity malaria, consequently risks deworming malaria affected populations. We examined association between geohelminths pregnancy Thai-Burmese border. Methodology Routine antenatal care (ANC) included active detection (weekly blood smear) (second weekly haematocrit)...
In a prospective infant cohort, 21 infants developed Plasmodium vivax malaria during their first year. Twelve of mothers also had in the corresponding pregnancies or postpartum period. The genotypes maternal and infections were all different. Eight 12 9 recurrent infections. Relapse parasite different to initial infection 13 20 (65%) compared with 5 24 (21%) (P = .02). P. relapses life are usually genetically homologous, whereas relapse adults may result from activation heterologous latent...
Chloroquine (CQ) resistant vivax malaria is spreading. In this case, Plasmodium infections during pregnancy and in the postpartum period were not satisfactorily cleared by CQ, despite adequate drug concentrations. A growth restricted infant was delivered. Poor susceptibility to CQ confirmed in-vitro molecular genotyping strongly suggestive of true recrudescence P. vivax. This first clinically laboratory case two high-grade parasite strains from Thailand.
The association between malaria during pregnancy and low birth weight (LBW) is well described. This manuscript aims to quantify the relative contribution of small-for-gestational-age (SGA) infants preterm (PTB) in pregnancies accurately dated by ultrasound on Thai-Myanmar border at Shoklo Malaria Research Unit. From 2001 2010 a population cohort prospectively followed pregnancies, we analyzed all singleton newborns who were live born, normal, weighed first hour life with gestational age (GA)...
Dihydroartemisinin-piperaquine (DHA-PPQ) is a promising new artemisinin combination treatment. There are no published data on the intentional use of drug in pregnancy. Between June 2006 and January 2007, 50 Karen pregnant women with recurrent P. falciparum infections, despite 7-day treatments quinine or artesunate (+/−clindamycin) both, were treated DHA-PPQ. This rescue treatment was effective well tolerated there evidence toxicity for mothers fetus. The PCR adjusted cure rate by Kaplan...
Currently, computer-animation programs are frequently used to instruct and stimulate young children in performing maximal expiratory flow/volume (MEFV) curves. The reproducibility performance of MEFV manoeuvres with without the use two (the “candles” “balloon” programs) were evaluated. Eighty-eight children, aged 4–8 yrs, randomly assigned one animation programs. All performed series at least three technically acceptable curves, incentive without, random order. With programs, a lower...
Castor oil is one of the most popular drugs for induction labour in a non-medical setting; however, published data on safety and effectiveness this compound to induce remain sparse.To assess castor pregnancies with an ultrasound estimated gestational at birth more than 40 weeks.Data were extracted from hospital-based records all pregnant women who attended antenatal clinics Thai-Burmese border weeks pregnant. The was expressed as time analysed Cox proportional hazards regression model....
Background Several studies have shown a prolonged or increased susceptibility to malaria in the post-partum period. A matched cohort study was conducted evaluate prospectively of women an area where P.falciparum and P.vivax are prevalent. Methods In low seasonal transmission on Thai-Myanmar border pregnant attending antenatal clinics were non-pregnant, non-post-partum control followed up until 12 weeks after delivery. Results Post-partum (n = 744) experienced significantly less episodes than...
Background: Anaemia in pregnancy is typically due to iron deficiency (IDA) but remains a complex and pervasive problem, particularly low resource settings. At clinics on the Myanmar–Thailand border, protocol was developed guide treatment by health workers antenatal care (ANC).Objective: To evaluate clinical use of treat anaemia pregnancy.Methods: The design descriptive retrospective analysis data obtained during standard protocol. Two consecutive haematocrits (HCT) <30% prompted change from...
Abstract During pregnancy a variety of immunological changes occur to accommodate the fetus. It is unknown whether these continue affect humoral immunity postpartum or how quickly they resolve. IgG levels were measured P. falciparum and vivax antigens in 201 controls over 12 weeks. Linear mixed-effects models assessed antibody maintenance time effect microscopically confirmed Plasmodium spp. infection on levels, this was different women compared with control women. Postpartum had reduced at...
In a few small studies an association between blood group O and placental malaria has been described. The relationship in pregnancy ( Plasmodium vivax falciparum ) was analyzed 1,468 women from three longitudinal cohort which weekly screening done systematically during pregnancy. One-third of (447 1,468) had at least one infection ABO phenotype not associated with the species infection, frequency attacks, symptoms malaria, hematocrit, or parasitemia
Although published data on the safety and effectiveness of castor oil for induction labor are sparse, it is widely used this purpose outside medical settings, especially by American nurse-midwives. Its low cost, easy storage, apparent contribute to its popularity. The results 4 small clinical trials evaluating were contradictory. This historical cohort investigated in women with an estimated gestation more than 40 weeks based ultrasound. Data obtained from hospital-based records pregnant who...
AbstractPostpartum women may have an altered susceptibility to Plasmodium falciparum and vivax. The relationship between naturally acquired malarial immunity malaria postpartum is yet be determined. IgG levels were measured against P. vivax antigens from delivery in 201 nonpregnant controls over 12 weeks. Associations time-varying antibody time first microscopically confirmed species-specific infection determined by Cox regression. prospective risk of similar control women. A 2-fold increase...
Background: The use of obstetric ultrasound in the diagnosis gestational trophoblastic disease (GTD) high-income settings is well established, leading to prompt management and high survival rates. Evidence from low-income suggests essential identifying complicated pregnancies, but with limited studies reviewing specific conditions including GTD.Objective: aim this study review role GTD a marginalized population on Thailand–Myanmar border. Antenatal became available rural setting 2001 care...
Boel, M.E.; Lee, S.J.; Rijken, M.J.; Paw, M.K.; Pimanpanarak, M.; Tan, S.O.; Singhasivanon, P.; Nosten, F.; McGready, R. Author Information