William A. Engle

ORCID: 0000-0003-4895-9731
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About
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Research Areas
  • Neonatal Respiratory Health Research
  • Infant Development and Preterm Care
  • Congenital Diaphragmatic Hernia Studies
  • Neuroscience of respiration and sleep
  • Congenital Heart Disease Studies
  • Neonatal and fetal brain pathology
  • Respiratory Support and Mechanisms
  • Tracheal and airway disorders
  • Birth, Development, and Health
  • Trauma and Emergency Care Studies
  • Infant Nutrition and Health
  • Neonatal and Maternal Infections
  • Cardiac Arrest and Resuscitation
  • Sepsis Diagnosis and Treatment
  • Neonatal Health and Biochemistry
  • Injury Epidemiology and Prevention
  • Preterm Birth and Chorioamnionitis
  • Ethics and Legal Issues in Pediatric Healthcare
  • Assisted Reproductive Technology and Twin Pregnancy
  • Automotive and Human Injury Biomechanics
  • Airway Management and Intubation Techniques
  • Child and Adolescent Health
  • Obstructive Sleep Apnea Research
  • Cardiovascular Conditions and Treatments
  • Metabolism and Genetic Disorders

Indiana University – Purdue University Indianapolis
2007-2022

Indiana University School of Medicine
2008-2022

Riley Hospital for Children
2009-2022

Indiana University Bloomington
2021

Indiana University Health
2020

Indiana University
1984-2019

Indianapolis Zoo
1985-2014

NYU Langone Health
2014

PAST Foundation
2008

Arab American Pharmacist Association
2007

The authors evaluated the risk of necrotizing enterocolitis (NEC) in very low birth weight infants receiving indomethacin (INDO) to close patent ductus arteriosus (PDA).Controversy exists regarding best method managing with PDA and whether employ medical management using INDO or surgical ligation ductus.Two hundred fifty-two premature symptomatic were given intravenously 0.2 mg/kg every 12 hours x 3 an attempt ductus. Patients for sex, weight, gestational age, closure, occurrence NEC, bowel...

10.1097/00000658-199609000-00011 article EN Annals of Surgery 1996-09-01

OBJECTIVE. We tested whether NICU teams trained in benchmarking and quality improvement would change practices improve rates of survival without bronchopulmonary dysplasia inborn neonates with birth weights <1250 g. METHODS. A cluster-randomized trial enrolled 4093 g at 17 centers the National Institute Child Health Human Development Neonatal Research Network. Three were selected as best performers, remaining 14 randomized to intervention or control. Changes free compared between...

10.1542/peds.2006-2656 article EN PEDIATRICS 2007-05-01

One hundred ten infants with congenital diaphragmatic hernia (CDH) developed life-threatening respiratory distress in the first 6 hours of life. Associated anomalies were present 33%. Twenty-eight 65 (43%) treated before 1987 (pre-extracorporeal membrane oxygenation [ECMO] era) survived after immediate CDH repair, and mechanical ventilation or without pharmacologic support. Only two 16 (12.5%) requiring a prosthetic patch survived. Since 1987, 31 46 (67.4%) birth weight, gestational age,...

10.1097/00000658-199210000-00009 article EN Annals of Surgery 1992-10-01

Postnatal steroid use decreases lung inflammation but increases impairment. We hypothesized that increased dose is associated with neurodevelopmental impairment, lower postmenstrual age at exposure and risk of bronchopulmonary dysplasia modifies the effect postnatal corticosteroid.

10.1542/peds.2008-1928 article EN PEDIATRICS 2009-02-10

Background: The authors report the cause of and risk factors for mortality in infants with Robin sequence identify characteristics associated quality-of-life outcomes. Methods: performed an 11-year retrospective review all treated at a neonatal intensive care unit. Patient were correlated to measures. Emergency room visits hospital admissions used assess Significant variables identified by means univariate analysis. Results: One hundred eighty-one consecutive identified. included following:...

10.1097/prs.0000000000000510 article EN Plastic & Reconstructive Surgery 2014-09-26

Objective. Oxygen delivery through nasal cannulae to convalescent preterm infants is a common but largely unstudied practice. To learn more about current cannula oxygen practices, we examined the variations in among centers of Neonatal Research Network, frequency prescription low levels oxygen, and success weaning room air. We hypothesized that some treated with were receiving equivalent those Methods. This was descriptive, nested, cohort study 187 birth weights <1250 g. All studied...

10.1542/peds.2004-2411 article EN PEDIATRICS 2005-09-30

BACKGROUND: Synchronized nasal intermittent positive-pressure ventilation (SNIPPV) use reduces reintubation rates compared with continuous positive airway pressure (NCPAP). Limited information is available on the outcomes of infants managed SNIPPV. OBJECTIVES: To compare SNIPPV (postextubation or for apnea) to not treated at 2 sites. METHODS: Clinical retrospective data was used evaluate in ≤1250 g birth weight (BW); and 3 BW subgroups (500–750, 751–1000, 1001–1250 g, decided a priori)....

10.1542/peds.2008-1302 article EN PEDIATRICS 2009-07-27

10.1016/0887-8994(85)90074-8 article EN Pediatric Neurology 1985-11-01

Safe transportation of preterm and low birth weight infants requires special considerations. Both physiologic immaturity must be taken into account to properly position such infants. This clinical report provides guidelines for pediatricians other caregivers who counsel parents about car safety seats.

10.1542/peds.2009-0559 article EN PEDIATRICS 2009-04-27

Several investigators have enumerated cellular populations in neonatal cord blood with variable results. In this study, the authors established reference ranges for lymphocyte subsets from healthy newborns using a whole lysis technique on Coulter Immunoprep Epics Leukocyte Preparation System (Coulter Immunology, Hialeah, FL). All analyses were performed flow cytometer by gating forward angle versus 90 degrees light scatter. Lymphocytes demonstrated all surface markers examined, including T4,...

10.1093/ajcp/93.2.263 article EN American Journal of Clinical Pathology 1990-02-01

To describe the outcome of young adults treated for hypoxemic respiratory failure with extracorporeal membrane oxygenation as neonates.The study was designed a multisite, cross sectional survey.The survey completed electronically or on paper by subjects and stored in secure data base.Subjects were surviving neonatal patients from eight institutions who were18 years old older.None.A questionnaire modified 2011 Behavioral Risk Factor Surveillance System National Health Interview Survey...

10.1097/pcc.0000000000001018 article EN Pediatric Critical Care Medicine 2016-11-03
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