A5001136111- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Immune Response and Inflammation
- Cytomegalovirus and herpesvirus research
- RNA Interference and Gene Delivery
- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Cancer Genomics and Diagnostics
- Molecular Sensors and Ion Detection
- Advanced biosensing and bioanalysis techniques
- Xenotransplantation and immune response
- Cancer Research and Treatments
- Immune cells in cancer
- Gastric Cancer Management and Outcomes
- Immunodeficiency and Autoimmune Disorders
- Genetic Mapping and Diversity in Plants and Animals
- Intestinal and Peritoneal Adhesions
- T-cell and Retrovirus Studies
- Intraperitoneal and Appendiceal Malignancies
- Sulfur Compounds in Biology
- Virus-based gene therapy research
- Genomics, phytochemicals, and oxidative stress
Zhejiang University of Technology
2023-2024
Bioscience (China)
2020-2022
Shenzhen International Travel Health Care Center
2020
University of Pittsburgh
1997-2018
Kyoto University
1996-2006
McMaster University
1998-2006
University of Pittsburgh Medical Center
1999
Hebei Medical University
1995
Abstract In this study, we investigated the impact of cigarette smoke on tumor immune surveillance and its consequences to lung burden in a murine metastasis model. Cigarette exposure significantly increased numbers metastases following B16-MO5 melanoma challenge. This effect was reversible; observed fewer nodules smoking cessation. Using RAG2−/− RAG2−/−γc−/− mice, provide strong evidence that incidence NK cell dependent. Furthermore, show suppressed activation attenuated CTL activity,...
The ability of regulatory T cells (Treg) to prolong allograft survival and promote transplant tolerance in lymphodepleted rodents is well established. Few studies, however, have addressed the therapeutic potential adoptively transferred, CD4+CD25+CD127−Foxp3+ clinically relevant large animal models. We infused ex vivo–expanded, functionally stable, nonselected Treg (up a maximum cumulative dose 1.87 billion cells) into antithymocyte globulin–lymphodepleted, MHC‐mismatched cynomolgus monkey...
Systemic administration of autologous regulatory dendritic cells (DCreg; unpulsed or pulsed with donor antigen [Ag]), prolongs allograft survival and promotes transplant tolerance in rodents. Here, we demonstrate that nonhuman primate (NHP) monocyte-derived DCreg preloaded cell membrane vesicles from allogeneic peripheral blood mononuclear induce T hyporesponsiveness to alloantigen (alloAg) vitro. These alloAg-pulsed (1.4-3.6 × 106 /kg) were administered intravenously, 1 day before...
Ex vivo-expanded cynomolgus monkey CD4(+)CD25(+)CD127(-) regulatory T cells (Treg) maintained Foxp3 demethylation status at the Treg-specific region, and potently suppressed cell proliferation through three rounds of expansion. When carboxyfluorescein succinimidyl ester- or violet dye 450-labeled autologous (auto) nonautologous (non-auto)-expanded Treg were infused into monkeys, number labeled auto-Treg in peripheral blood declined rapidly during first week, but persisted low levels both...
Abstract By using adoptive transfer of Ag-loaded bone marrow-derived dendritic cells (BMDC), we have established an in vivo model CTL priming. Activation these experiments required both CD4+ T and CD154, demonstrating that this reflects cell-dependent cell (DC) licensing. Because IL-12 has been suggested to play important role activation by DC, examined the ability BMDC prime complete absence p40-deficient mice. We observed does not affect phenotype or allostimulatory function after vitro...
Increasing evidence from small animal models shows that myeloid-derived suppressor cells (MDSCs) can play a crucial role in inhibiting allograft rejection and promoting transplant tolerance. We identified CD3(-)CD20(-)HLA-DR(-)CD14(+)CD33(+)CD11b(+) peripheral blood of healthy rhesus macaques. These putative monocytic MDSCs constituted 2.1% ± 1.7% lin(-)HLA-DR(-) mononuclear cells. Administration granulocyte-macrophage colony-stimulating factor (CSF) granulocyte CSF increased their incidence...
Increasing exposure to environmental endocrine disruptor, xeno-estrogen, is a serious hazard male reproductive activity. To explore possible genetic control in susceptibility the weight reduction of testes induced by continuous administration synthetic estrogen, diethylstilbesterol, were investigated quantitative trait analysis LEXF and FXLE recombinant inbred strain rats, consisting 21 independent strains, 9 their substrains, parental F344/Stm LE/Stm (F344 × LE)F1. For testes, one highly...
Alemtuzumab (Campath-1H) is a humanized monoclonal antibody (Ab) directed against CD52 that depletes lymphocytes and other leukocytes, mainly by complement-dependent mechanisms. We investigated the influence of alemtuzumab (i) on ex vivo-expanded cynomolgus monkey regulatory T cells (Treg) generated for prospective use in adoptive cell therapy (ii) naturally occurring Treg following infusion. were isolated from PBMC lymph nodes expanded two rounds. expression, binding both...
4062 Background: TST001 is a recombinant humanized IgG1 antibody specifically against human Claudin 18.2 (CLDN18.2) with high affinity and enhanced FcR engaging of NK cells, which can induce strong antibody-dependent cellular cytotoxicity (ADCC) activities. monotherapy dose-escalation study has been completed (IGCC2022-ABS-1152) promising anti-tumor activities were observed in advanced gastric cancer patients CLDN18.2 overexpression who had failed multiple lines prior therapies. The current...
TPS375 Background: In normal conditions, Claudin (CLDN)18.2 is a tight junction protein with expression strictly confined to differentiated epithelial cells in gastric mucosa. CLDN18.2 has been found be upregulated, and involved tumor development progression variety of types such as gastric, pancreatic, bile duct cancer (BTC). The biological characteristics suggest it an ideal therapeutic target for drug development. IMAB362 the first anti-CLDN18.2 monoclonal antibody (mAb) high potency have...
Abstract Memory T cell (Tmem) responses play a critical role in the outcome of allo-transplantation. While T-box transcription factor Eomesodermin (Eomes) maintenance antigen-specific Tmem is well studied, little known about Eomes+CD8+T after transplantation. We evaluated phenotype and function allo-reactive cells healthy volunteers kidney transplant patients their relation to outcome. High Eomes expression by steady-state CD8+T correlated with effector memory phenotype. Following...
ABSTRACT The pathogenicities of the murine AIDS (MAIDS) virus complex (LP-BM5) and ecotropic helper (BM5eco) isolated from to BALB/c nude mice were studied elucidate possible role replication-competent in inducing monoclonal outgrowth lymphoid cells. Neither LP-BM5 nor BM5eco was pathogenic adult mice. However, B-cell lymphoma developed with a very high frequency when either inoculated into newborn ( nu/nu ) cells easily transplanted These results suggested that MAIDS plays an important...
Transforming growth factor β1 (TGFβ1) plays a key role in T cell homeostasis and peripheral tolerance. We evaluated the influence of novel human mutant TGFβ1/Fc (human IgG4 Fc) fusion protein on memory CD4+ CD8+ (Tmem) responses vitro their recovery following antithymocyte globulin (ATG)-mediated lymphodepletion monkeys. induced Smad2/3 phosphorylation rhesus blood mononuclear cells augmented suppressive effect rapamycin Tmem proliferation after either alloactivation or anti-CD3/CD28...
The effects of two host genes on retro virus‐induced murine lymphoma were evaluated by studying 114 F2 intercross mice between SL/Kh and AKR/Ms mice. Out 47 T‐lymphoma‐bearing mice, 45 had the AKR‐derived dominant allele at Tlsm‐1 . length latent period was not related to type tumor. Instead, it significantly shortened a recessive SL/Kh‐derived major histocompatibility complex ( MHC )‐linked locus Chr. 17. A quantitative trait analysis yielded maximal logarithm likelihood ratio for linkage...