A5085969218- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Cancer Treatment and Pharmacology
- Pancreatic and Hepatic Oncology Research
- Genetic factors in colorectal cancer
- Radiomics and Machine Learning in Medical Imaging
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal and Anal Carcinomas
- Colorectal Cancer Surgical Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Genomics and Diagnostics
- PI3K/AKT/mTOR signaling in cancer
- Gastrointestinal Tumor Research and Treatment
- Cancer Cells and Metastasis
- Heat shock proteins research
- Liver physiology and pathology
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Genetic and Kidney Cyst Diseases
- Tuberculosis Research and Epidemiology
- Cancer Mechanisms and Therapy
- Autophagy in Disease and Therapy
- Frailty in Older Adults
- Veterinary medicine and infectious diseases
- Viral-associated cancers and disorders
University of Amsterdam
2021-2024
Amsterdam University Medical Centers
2021-2024
Oncode Institute
2021-2024
University of Naples Federico II
2021-2023
Amsterdam UMC Location University of Amsterdam
2023
Centre National de la Recherche Scientifique
2020-2022
Institut de Génétique Moléculaire de Montpellier
2020-2022
Université de Montpellier
2020-2022
University of Bologna
2012
Policlinico S.Orsola-Malpighi
2006-2007
Glioblastoma (GBM) is the most common primary brain tumor in adults with a median survival of approximately 15 months; therefore, more effective treatment options for GBM are required. To identify new drugs targeting GBMs, we performed high-throughput drug screen using patient-derived neurospheres cultured to preferentially retain their glioblastoma stem cell (GSC) phenotype.High-throughput screening was on GSCs followed by dose-response assay 5 identified original "hits." A PI3K/mTOR...
Article25 October 2022Open Access Transparent process Loss of primary cilia promotes inflammation and carcinogenesis Conception Paul Institut de Génétique Moléculaire Montpellier, Univ CNRS, Label "Equipe FRM", France Contribution: Conceptualization, Formal analysis, Investigation, Methodology Search for more papers by this author Ruizhi Tang orcid.org/0000-0001-6512-845X Ciro Longobardi orcid.org/0000-0003-4965-9976 Center Experimental Molecular Medicine, Cancer Amsterdam, Amsterdam UMC,...
To clarify the function of cyclin A2 in colon homeostasis and colorectal cancer (CRC), we generated mice deficient for colonic epithelial cells (CECs). Colons these displayed architectural changes mucosa signs inflammation, as well increased proliferation CECs associated with appearance low- high-grade dysplasias. The main initial events triggering those alterations A2–deficient appeared to be abnormal mitoses DNA damage. Cyclin deletion promoted development dysplasia adenocarcinomas a...
Abstract The R2TP chaperone cooperates with HSP90 to integrate newly synthesized proteins into multi-subunit complexes, yet its role in tissue homeostasis is unknown. Here, we generated conditional, inducible knock-out mice for Rpap3 inactivate this core component of the intestinal epithelium. In adult mice, invalidation caused destruction small epithelium and death within 10 days. Levels substrates decreased, strong effects on mTOR, ATM ATR. Proliferative stem cells progenitors deficient...
Colorectal cancer (CRC) can be divided into four consensus molecular subtypes (CMS), each with distinct biological features. CMS4 is associated epithelial-mesenchymal transition and stromal infiltration (Guinney et al., Nat Med 21:1350-6, 2015; Linnekamp Cell Death Differ 25:616-33, 2018), whereas clinically it characterized by lower responses to adjuvant therapy, higher incidence of metastatic spreading hence dismal prognosis (Buikhuisen Oncogenesis 9:66, 2020).To understand the biology...
Around 20-30% of patients with hepatic metastasis from colorectal cancer can undergo liver resection, but the increased response rate obtained addition monoclonal antibodies to chemotherapy regimens could result in a higher surgery. In this report we describe case patient who underwent resection after neoadjuvant treatment capecitabine, oxaliplatin and bevacizumab achieved complete pathological metastasis. A preoperative CT scan demonstrated partial while 18FDG-PET correctly evaluated...
The consensus molecular subtype (CMS) classification divides colorectal cancer (CRC) into four distinct subtypes based on RNA expression profiles. biological differences between CMSs are already present in CRC precursor lesions, but not all pose the same risk of malignant transformation. To fully understand path to transformation and determine whether CMS is a fixed entity during progression, genomic transcriptomic data from two regions lesion were compared: region carcinoma region. In...
e14590 Background: Biliary tract cancers are rare malignancies with a very poor prognosis. Several studies comparing chemotherapy and supportive care showed significant survival prolongation improvement in life quality chemotherapy. The association of gemcitabine platinum compound is considered the standard first-line treatment but there no adequate data supporting any second-line therapy. Our retrospective study aims at evaluating retrospectively impact this setting. Methods: We reviewed...
Colorectal cancer (CRC) is the third most common worldwide and it second leading cause of death. In CRC, as in cancers, formation metastasis through migration invasion cells to distant organs associated with a dismal prognosis. The study mechanisms cancer, and, particular, changed last decade due introduction organoids. These represent step forward terms complexity from cell lines allowed use mouse models research be limited. Although organoids faithfully model cellular current protocols do...
3614 Background: The aim of this study was to evaluate the correlation among biomarkers, pathological response and clinical outcomes in patients (pts) with rectal cancer submitted neoadjuvant chemoradiotherapy. Methods: Pts entering had adenocarcinoma, uT3/4N-/+ or uT2N-/+ inferior location. Chemotherapy consisted oxaliplatin 60 mg/m 2 weekly infusion IV for 6 times 5-fluorouracil 225 /die continuous d 1–38. Radiotherapy delivered up a dose 50.4 Gy daily fractions 1.8 Rectal surgery TME...