A5100996132- Renal Diseases and Glomerulopathies
- Cancer Genomics and Diagnostics
- Knee injuries and reconstruction techniques
- Genetic factors in colorectal cancer
- Shoulder Injury and Treatment
- Liver Disease Diagnosis and Treatment
- Eosinophilic Esophagitis
- Liver Disease and Transplantation
- Autoimmune Bullous Skin Diseases
- Colorectal Cancer Treatments and Studies
- Systemic Lupus Erythematosus Research
- Diabetes Management and Education
- Genetic and phenotypic traits in livestock
- Orthopedic Surgery and Rehabilitation
- Genetic Syndromes and Imprinting
- ATP Synthase and ATPases Research
- Neuroblastoma Research and Treatments
- Forensic and Genetic Research
- Biomarkers in Disease Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Atherosclerosis and Cardiovascular Diseases
- Cancer-related gene regulation
- Thyroid Cancer Diagnosis and Treatment
- Climate Change and Health Impacts
- Vitamin D Research Studies
First Affiliated Hospital of Zhengzhou University
2023-2025
Nanjing University of Chinese Medicine
2024
Jiangsu Province Hospital
2024
Hainan General Hospital
2017-2024
University Medical Center Utrecht
2024
Hainan Medical University
2024
RELX Group (United States)
2023
Zhengzhou University
2023
Lanzhou University
2023
Genome Institute of Singapore
2015-2017
Objective The purpose of this manuscript is to identify longitudinal trajectories changes in triglyceride glucose (TyG) index and investigate the association TyG with risk lean nonalcoholic fatty liver disease (NAFLD). Methods Using data from 1,109 participants Health Management Cohort study, we used Latent Class Growth Modeling (LCGM) develop trajectories. a Cox proportional hazard model, relationship between incident NAFLD was analyzed. Restricted cubic splines (RCS) were visually display...
Genomics-driven cancer therapeutics has gained prominence in personalized treatment. However, its utility indications lacking biomarker-driven treatment strategies remains limited. Here we present a "phenotype-driven precision-oncology" approach, based on the notion that biological response to perturbations, chemical or genetic, ex vivo patient-individualized models can serve as predictive biomarkers for therapeutic clinic. We generated library of "screenable" patient-derived primary...
Colorectal cancer with metastases limited to the liver (liver-limited mCRC) is a distinct clinical subset characterized by possible cure surgery. We performed high-depth sequencing of over 750 cancer-associated genes and copy number profiling in matched primary, metastasis normal tissues characterize genomic progression 18 patients liver-limited mCRC. High depth Illumina use three different variant callers enable comprehensive accurate identification somatic variants down 2.5% allele...
Intratumor heterogeneity ( ITH ) contributes to cancer progression and chemoresistance. We sought comprehensively describe of somatic mutations, copy number, transcriptomic alterations involving clinically biologically relevant gene pathways in colorectal CRC ). performed multiregion, high‐depth (384× on average) sequencing 799 cancer‐associated genes 24 spatially separated primary tumor nonmalignant tissues from four treatment‐naïve patients. then used ultra‐deep (17 075× accurately verify...
This longitudinal study sought to identify distinct body mass index (BMI) trajectories and investigate the impact of these level-independent BMI on prevalence thyroid nodules (TN). encompassed a cohort 1967 participants from hospital in China. Utilizing latent class growth mixture modeling (LCGMM), four trajectory groups were identified based individuals without TN 2017 2019. The occurrence was monitored 2020 2021. classes age considered potential risk factors for development. After...
Hypertension, one of the most prevalent chronic non-communicable diseases worldwide, is a primary risk factor for stroke and coronary heart disease. This study investigated dynamic changes in protein post-translational modifications (PTMs) associated biological processes during hypertension progression by comparing urinary proteome PTMs between stroke-prone spontaneously hypertensive rats (SHRSP) normal at 1-, 8-, 14-15-month-old stages. Results revealed both stage-specific shared PTM...
Mongolians have played a significant role in modern human evolution, especially after the rise of Genghis Khan (1162[?]–1227). Although social cultural impacts and Mongolian population been well documented, explorations their genome structure genetic imprints on other populations lacking. We here present male individual. The was de novo assembled using total 130.8-fold genomic data produced from massively parallel whole-genome sequencing. identified high-confidence variation sets, including...
IgA nephropathy (IgAN) is the major cause of end-stage renal disease(ESRD) in Asia and its pathogenesis influenced by both genetic environmental factors. Single nucleotide polymorphisms (SNPs) IL1R1 IL-1R2 may be associated with susceptibility to IgAN. In this study, we study association between variants IL-1R1 risk Chinese Han population.In allelic model analysis, rs10490571 rs3917225 were a 1.40-fold, 1.31-fold increased nephropathy, respectively. was 1.46-fold IgAN dominant 1.36-fold...
Compared to angiosperms, conifers represent more complex genomes with larger giga-genome size.To detect large-scale single nucleotide polymorphisms (SNPs), whole genome sequencing of a conifer population is still unaffordable.In this work, we report the use DNA specific-locus amplified fragment (SLAF-seq) for SNP detection in Chinese fir (Cunninghamia lanceolata (Lamb.)Hook), an ecological and economic important China.SLAF libraries 18 parent clones 2.5 generation seed orchard were sequenced...
The incidence and mortality of chronic kidney disease (CKD) are increasing globally. Studies have demonstrated the significance genetic risk factors in progression CKD. Telomerase reverse transcriptase (TERT) may be implicated development This study aimed to investigate correlation between TERT gene variants susceptibility CKD Chinese population. A total 507 patients with 510 healthy controls were recruited for this case-control study. Four candidate loci identified using MassARRAY platform....
IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide, but etiology and pathogenesis continue to be poorly understood. Polymorphisms in cytokine genes may play a role IgAN. The incidence different between diverse ethnic groups suggested important genetic influences on its pathogenesis. We genotype 10 single nucleotide polymorphisms (SNPs) IL-1B IL-6 gene using Sequenom Mass-ARRAY technology from 417 IgAN patients 463 healthy controls Chinese Han population....
// Xiaohong Yang 1, * , Yin Zhang Wenning Li 1 Yan Su Dan Niu 2 Yanni Wang Haiyang Huang 3 Hui Han Daofa Maowei Xie Huiluan Wentan Xu and Jiali Wei Department of Nephrology, Hainan General Hospital, Haikou 570311, China The First Affiliated Hospital Xi’an Jiaotong University, 710061, Central Laboratory, These authors have contributed equally to this work Correspondence to: Wei, email: drjialiwei@163.com Keywords: IgA nephropathy (IgAN), MPHOSPH6, single nucleotide polymorphisms (SNPs),...
Abstract BACKGROUND Pediatric H3K27-altered diffuse midline glioma (DMG) remains incurable, with median overall survival of less than one year. Ineffectiveness chemotherapy is largely attributed to the blood–brain barrier, hindering drug exposure tumor. Current sensitivity testing use concentrations vastly different from those attainable in human brain, optimal combination, timing, and sequence drugs remaining underexplored. This study aims systematically select validate EMA/FDA approved for...
A rotating machinery fault diagnosis method based on recurrence characteristics and model-agnostic meta