A5101413995- Sepsis Diagnosis and Treatment
- Vitamin C and Antioxidants Research
- Hemodynamic Monitoring and Therapy
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Renal function and acid-base balance
- Intestinal and Peritoneal Adhesions
- Pancreatitis Pathology and Treatment
- Genetics and Neurodevelopmental Disorders
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Atrial Fibrillation Management and Outcomes
- Tea Polyphenols and Effects
- Blood Pressure and Hypertension Studies
- Genomic variations and chromosomal abnormalities
- Adrenal Hormones and Disorders
- Sirtuins and Resveratrol in Medicine
- Salivary Gland Disorders and Functions
- Behavioral Health and Interventions
- Cardiovascular Disease and Adiposity
- Cardiovascular Function and Risk Factors
- Genomics and Rare Diseases
- Media Influence and Health
- Liver Disease and Transplantation
- Galectins and Cancer Biology
- Cardiac electrophysiology and arrhythmias
Shanghai Jiao Tong University
2023-2025
Ruijin Hospital
2023-2025
First Affiliated Hospital of Zhengzhou University
2023-2024
Harbin Medical University
2021-2024
First Affiliated Hospital of Harbin Medical University
2021-2024
North China University of Science and Technology
2024
The First Hospital of Changsha
2024
Zhengzhou University
2023-2024
Huazhong University of Science and Technology
2024
Beijing United Family Hospital
2022
Objective The purpose of this manuscript is to identify longitudinal trajectories changes in triglyceride glucose (TyG) index and investigate the association TyG with risk lean nonalcoholic fatty liver disease (NAFLD). Methods Using data from 1,109 participants Health Management Cohort study, we used Latent Class Growth Modeling (LCGM) develop trajectories. a Cox proportional hazard model, relationship between incident NAFLD was analyzed. Restricted cubic splines (RCS) were visually display...
Abstract Background The aim of this study was to investigate whether high-dose intravenous vitamin C (HDIVC) could decrease the mortality rate within 28 days among patients moderately severe acute pancreatitis (MSAP) and (SAP). Methods In randomized, placebo-controlled trial, diagnosed with predicted MSAP or SAP 72 h symptom onset were enrolled receive either a infusion (200 mg/kg/24 h) matched placebo for 7 days. primary outcome 28-day mortality. Results 212 adults including 155 57 from...
The importance of N6-methyladenine (m6A) in mRNA metabolism, physiology, pathology and other life processes is well recognized. However, the exact role m6A regulators primary Sjögren's syndrome (PSS) remains unclear. In this study, we used bioinformatics machine learning random forest approach to screen eight key from Gene Expression Omnibus GSE7451, GSE40611 GSE84844 datasets. An accurate nomogram model for predicting PSS risk was established based on these regulators. And using consensus...
Purpose: Both nonthyroidal illness syndrome (NTIS) and disseminated intravascular coagulation (DIC) are commonly occurred in sepsis. The objective of this study is to evaluate the association between NTIS DIC, as well their impacts on mortality adults with Patients methods: A total 1219 septic patients two Chinese academic centers from October 2012 2022 were enrolled analysis. We conduct logistic regression models analyze independent risk factors for DIC. Modified Poisson used estimate...
In critically ill patients, the stress hyperglycemia ratio (SHR) was significantly associated with mortality. However, relationship between SHR and mortality in septic patients is still unclear.In this study, sepsis from two Chinese academic centers were identified divided into quartiles based on levels.
Nonthyroidal illness syndrome (NTIS) is a common endocrine dysfunction predicting unfavorable outcomes in critical illness. The objective of the study to evaluate association between different NTIS subtypes with septic patients.Septic patients two Chinese academic centers from October 2012 and 2022 are enrolled analysis. Multivariable regressions used assess associations outcomes. Outcomes include in-hospital mortality, length stay hospital (LOS), non-invasive ventilation failure weaning...
1. American Academy of Addiction Psychiatry. Nicotine Dependence. Accessed November 21, 2023. https://www.aaap.org/wp-conten... Google Scholar
Acute pancreatitis is a common gastrointestinal disease. The mortality of patients affected by severe acute (SAP) remains high. It unclear whether high-dose intravenous vitamin C (HDIVC) therapy could improve the prognosis these patients. current prospective, randomized, double-blinded, placebo-controlled study will explore effect on in with moderately and pancreatitis.A total 418 participants who meet eligible criteria be randomly assigned 1:1 ratio to receive treatment HDIVC (200 mg/kg/24...
Abstract Background The calcium/calmodulin‐dependent serine protein kinase gene ( CASK ) is an essential in mammals, critical for neurodevelopment. purpose of this study to expand the understanding diagnosis ‐linked disorders. Materials/Methods From clinical and genetic mutational analyses, relevant data 2 Han Chinese patients were collected analyzed. Real‐time quantitative PCR (RT‐qPCR) was performed investigate expression levels patients. X‐chromosome inactivation (XCI) patterns their...
The current study aimed to delve deeper into the intricate role of N7-methylguanosine (m7G) regulators in etiology and pathogenesis primary Sjögren's syndrome (PSS). PSS is a chronic autoimmune disease characterized by inflammation salivary lacrimal glands, leading dry eyes mouth. Despite its prevalence impact on patient quality life, underlying mechanisms remain incompletely understood. To address this knowledge gap, we utilized bioinformatics techniques powerful extreme gradient boosting...
New-onset atrial fibrillation (NOAF) and sepsis-induced coagulopathy (SIC) are severe complications in septic patients. However, the relationship between NOAF SIC score has not been clearly defined. This study aims to investigate association NOAF, as well their effect on mortality sepsis.
(-)-Epicatechin (EPI) is beneficial for cardiovascular health. Trimethylamine N-oxide (TMAO), a gut microbe-derived food metabolite, strongly associated with the risk of diseases. However, effects and underlying mechanisms EPI on TMAO-induced cardiac hypertrophy remain unclear. This study aimed to determine whether inhibits hypertrophy. Plasma levels TMAO in control participants patients were measured analyzed. Male C57BL/6 mice randomly divided into group, group + group. According groups...
Abstract BackgroundArrhythmias are potential harmful diseases to human beings, especially atrial fibrillation and ventricular arrhythmia, for causing serious consequences such as acute stroke or even sudden cardiac death. Recently the screening of asymptomatic by using long-term ECG monitoring has been widely noticed. The study is evaluate significance detective arrhythmia in elderly “so called” healthy people who never have symptoms palpitation, short breath deny previous history...
Abstract Objective This study was conducted to investigate the hypertension and arterial stiffness (AS) in predicting future atherosclerotic cardiovascular disease (ASCVD) risk. Methods: We included 6530 participants from Chinese People′s Liberation Army General Hospital. AS assessed by measuring brachial-ankle pulse wave velocity (baPWV) were stratified into two groups: ASCVD≥10% or ASCVD<10% a risk threshold of 10%. The Kaplan-Meier survival analysis Cox proportional model evaluated...