A5006602295- Advanced Chemical Sensor Technologies
- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Advanced Nanomaterials in Catalysis
- Biochemical Analysis and Sensing Techniques
- Acoustic Wave Resonator Technologies
- Analytical Chemistry and Chromatography
- Mass Spectrometry Techniques and Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Nicotinic Acetylcholine Receptors Study
- Olfactory and Sensory Function Studies
- Identification and Quantification in Food
- Molecular Sensors and Ion Detection
- Electrochemical sensors and biosensors
- Metabolomics and Mass Spectrometry Studies
- Food Quality and Safety Studies
- Electrochemical Analysis and Applications
- Alzheimer's disease research and treatments
- Phytochemicals and Antioxidant Activities
- Fermentation and Sensory Analysis
- Neurological Disease Mechanisms and Treatments
- RNA Interference and Gene Delivery
- Advanced Computing and Algorithms
- Ziziphus Jujuba Studies and Applications
- Telomeres, Telomerase, and Senescence
Beijing Academy of Science and Technology
2023-2025
Tobacco Research Institute
2016-2024
Zhengzhou University
2022-2024
China Tobacco
2016-2021
Beijing National Laboratory for Molecular Sciences
2012-2013
Peking University
2010-2013
Toehold-mediated strand displacement reaction (SDR) is first introduced to develop a simple quartz crystal microbalance (QCM) biosensor without an enzyme or label at normal temperature for highly selective and sensitive detection of single-nucleotide polymorphism (SNP) in the p53 tumor suppressor gene. A hairpin capture probe with external toehold designed immobilized on gold electrode surface QCM. successive SDR initiated by target sequence hybridization domain ends unfolding probe....
A self-assembled DNA nanostructure as an efficient signal amplifier was introduced to create a simple and label-free quartz crystal microbalance with dissipation monitoring (QCM-D) biosensing platform for highly sensitive selective detection of nucleic acids.
Most of the dynamic DNA devices are rationally constructed by utilizing toehold-mediated strand displacement reactions. However, such approaches have been mainly limited to operation with double-stranded hybridization and lack versatility scaffold responses for additional levels controlling Herein, we propose a toehold activation strategy based on tetraplex (G-quadruplex or i-motif), where domain is designed attaching complementary single-stranded segment (CS) G-rich/C-rich segment....
The interaction mechanisms between vanillin and olfactory receptors were studied by computational chemistry approaches. Results showed that 10 exhibited different affinities for (-4.992∼-6.518 kcal/mol). Residues Arg286 (81%, OR2G2), His154 (78%, OR10G4; 62%, OR10G7), His104 (72%, OR10G4), Gly203 (57%, OR1L3), Val182 (58%, OR2J2), Glu182 (51%, OR5AC2) with high frequencies particularly contributed to recognition. Hydrogen bonding coupled hydrophobic interactions the key forces of binding,...
A facile approach was developed to assemble DNA-functionalized gold nanoparticles on the electrospun nanofibers. This novel nanocomposite successfully applied constructing a highly sensitive and selective fluorescent sensor for nucleic acids.
Recent findings have thrust poly(ADP-ribose) polymerase-1 (PARP-1) into the limelight as a potential biomarker and chemotherapeutic target for cancer. Thus, sensitive method detection of PARP-1 is necessary early diagnosis cancer drug development. However, poor electrochemical optical activity its product (PAR) prompted researchers to develop more methods. Here, we developed an efficient determination by using quartz crystal microbalance (QCM) because it mass-sensitive. Once activated...
Xiao Mo Xiang You (XMXY) is a traditional Chinese sesame oil variety that obtained through hot water flotation process. This unique process gives the aroma, health benefits, and excellent product stability. Although XMXY always most expensive among all varieties, it usually used as flavoring in many daily food products increasingly popular. In order to reveal characteristics of oil, volatile components, sensory evaluation, oxidation stability five samples were, respectively, analyzed by...
A quartz crystal microbalance with dissipation monitoring (QCM-D) sensor was developed for highly sensitive and specific detection of mercury(II) ions (Hg2+) a tunable dynamic range, using oligonucleotide-functionalized gold nanoparticles (GNPs) both frequency amplification. The fabrication the employed 'sandwich-type' strategy, formation T–Hg2+–T structures in linker DNA reduced hybridization GNPs-tagged on electrode, which could be used as molecular switch Hg2+ sensing. This QCM-D mercury...
Sweetening compounds are commonly incorporated into food products to enhance their texture and flavor, thereby indicating product quality. 4-Hydroxy-2,5-dimethyl-3(2H)-furanone (HDMF) is a sweet aromatic compound characterized by its pineapple-like baking scent. While it serves as taste enhancer in various industries, including wine production soy sauce manufacturing, HDMF also exhibits DNA-damaging activity foods. In this study, fluorescence detection method based on resonance energy...
Herein, a soluble graphene-based material exhibiting the aggregation-induced emission (AIE) feature was prepared for first time <italic>via</italic> wet chemistry by chemical reduction of graphene oxide (GO).
The disposition and metabolism of nicotine in the brain is an important determinant its exposure. We have developed a novel method for dynamic determination metabolites rat blood by simultaneous microdialysis sampling, stable-isotope labeling, ultra high-performance liquid chromatography–high-resolution mass spectrometry (UHPLC–HRMS) assaying. Microdialysis probes were inserted into both right striatum jugular vein Sprague–Dawley rats. collections dialystes after intraperitoneal injection...
Surface browning plays a major role in the quality loss of fresh-cut potatoes. Untargeted metabolomics were used to understand metabolic changes potato during process. Their metabolites profiled by ultra-high performance liquid chromatography coupled with high resolution mass spectrometry (UHPLC-HRMS). Data processing and metabolite annotation completed Compound Discoverer 3.3 software. Statistical analysis was applied screen key correlating Fifteen responsible for process putatively...
A mass-sensitive quartz crystal microbalance biosensor was constructed for telomerase sensing based on gold nanoparticle induced signal amplification.
The excessive flavorings in food are a growing public health concern, particularly foods for infants and children. A rapid simple method simultaneous detection of multiple is urgently needed. In this work, with direct analysis real time-mass spectrometry has been developed applied to the determination four flavorings, including maltol, ethyl vanillin, vanillin. ionization efficiency flavor compounds quantitatively-dip-it probe mode was compared that quick strip mode, which revealed...