A5025632225- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Ovarian function and disorders
- Gestational Diabetes Research and Management
- Birth, Development, and Health
- Reproductive Biology and Fertility
- Parathyroid Disorders and Treatments
- Pancreatic function and diabetes
- Diabetes and associated disorders
- PI3K/AKT/mTOR signaling in cancer
- Protein Kinase Regulation and GTPase Signaling
- Biomarkers in Disease Mechanisms
- Regulation of Appetite and Obesity
- Growth Hormone and Insulin-like Growth Factors
- Cancer, Hypoxia, and Metabolism
- Eating Disorders and Behaviors
- Reproductive System and Pregnancy
- Cancer-related Molecular Pathways
- Apelin-related biomedical research
- Pregnancy and preeclampsia studies
- Diet and metabolism studies
- Lipid metabolism and disorders
- Diabetes Management and Research
- Genetic Syndromes and Imprinting
Sheba Medical Center
2015-2025
Tel Aviv University
2005-2023
Institute of Endocrinology
1994-2020
Edmond and Lily Safra Children's Hospital
2011-2013
Ben-Gurion University of the Negev
1998
Tumor necrosis factor alpha (TNFalpha) or chronic hyperinsulinemia that induce insulin resistance trigger increased Ser/Thr phosphorylation of the receptor (IR) and its major substrates, IRS-1 IRS-2. To unravel molecular basis for this uncoupling in signaling, we undertook to study interaction Ser/Thr-phosphorylated IRS-2 with receptor. We could demonstrate that, similar IRS-1, also interacts juxtamembrane (JM) domain (amino acids 943-984) but not carboxyl-terminal region 1245-1331) IR...
Prolonged exposure of 3T3-L1 adipocytes to micromolar concentrations H2O2 results in an impaired response the acute metabolic effects insulin. In this study, we further characterized mechanisms by which oxidative stress impairs insulin stimulation glucose transport activity. Although induced a 2.5-fold increase plasma membrane GLUT4 content and 50% reduction its abundance low-density microsomal (LDM) fraction control cells, oxidation completely prevented these responses. The net effect on...
Tumor necrosis factor-α (TNF) has been suggested to be the mediator of insulin resistance in infection, tumor cachexia, and obesity. We have previously shown that TNF diminishes insulin-induced tyrosine phosphorylation receptor substrate 1 (IRS-1). The current work examines potential mechanisms mediate this event. effect on IRS-1 Fao hepatoma cells was not associated with a significant reduction kinase activity as measured <i>in vitro</i> but impaired association phosphatidylinositol...
Adiponectin is an adipocyte-derived plasma protein with insulin-sensitizing and antiatherosclerotic properties. The aim of this study was to examine whether adiponectin present in human fetal blood, define its association birth weight, evaluate dynamic changes levels occur during the early neonatal period. Cord blood were extremely high (71.0 +/- 21.0 microg/ml; n = 51) compared serum children adults positively correlated weights (r 0.4; P < 0.01). No significant differences found between...
Incubation of cells with insulin leads to a transient rise in Tyr phosphorylation receptor substrate (IRS) proteins, accompanied by elevation their Ser(P)/Thr(P) content and dissociation from the (IR). Wortmannin, phosphatidylinositol 3-kinase inhibitor, selectively prevented increase IRS-1, its IR, decrease Tyr(P) following 60 min treatment. Four conserved sites within phosphotyrosine binding/SAIN domains IRS-1 IRS-2 served asin vitro substrates for protein kinase B (PKB), Ser/Thr...
The sphingomyelin pathway is a newly described signal transduction mediating the action of several cytokines including tumor necrosis factor-alpha (TNF). TNF was recently shown to interfere with insulin-induced tyrosine phosphorylation insulin receptor substrate-1 (IRS-1). In this work we examined possible effect direct activation on IRS-1. Incubation insulin-sensitive rat hepatoma Fao cells bacterial sphingomyelinase (SMase) that causes membrane hydrolysis led time- and dose-dependent...
Does the administration of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccine have an association with ovarian reserve as expressed by circulating anti-Müllerian hormone (AMH) levels?Ovarian assessed serum AMH levels is not altered at 3 months following SARS-CoV-2 vaccination.A possible impact infection or vaccination through interaction between oocyte and somatic cells could be ruled out, however, data are limited.This a prospective study conducted university...
Abstract Sexual dimorphisms are responsible for profound metabolic differences in health and behavior. Whether males females react differently to environmental cues, such as solar ultraviolet (UV) exposure, is unknown. Here we show that exposure induces food-seeking behavior, food intake, behavior intake men, but not women, through epidemiological evidence of approximately 3,000 individuals throughout the year. In mice, UVB leads increased weight gain, with a sexual dimorphism towards males....
Several studies assessed adiponectin levels in anorexia nervosa (AN) patients, however, data regarding the dynamics of changes during refeeding these patients is limited and contradicting.Our objective was to assess distribution its different isoforms AN before after long-term refeeding, relate them alterations body mass index, leptin, insulin sensitivity, additional endocrine parameters.We conducted a longitudinal controlled study 38 female adolescent malnourished inpatients, with 13 young,...
To determine correlations between chemicals in follicular fluid (FF) and reproductive hormone levels.
OBJECTIVE Stress stimuli such as tumor necrosis factor (TNF) have been shown to induce insulin receptor substrate (IRS)-1 serine phosphorylation and resistance by transactivation of ErbB receptors. We aimed at elucidating the potential role p38 mitogen-activated protein kinase (p38MAPK) in mediating stress-induced receptors activation. RESEARCH DESIGN AND METHODS p38MAPK effect on ErbBs signaling was assessed Fao or HepG2 cells, exposed stress stimuli, metabolic parameters ob/ob C57/BL6...
Adiponectin receptor 1 (AdipoR1) mediates adiponectin's pleiotropic effects in muscle and liver plays an important role the regulation of insulin resistance diabetes. Here, we demonstrate a pivotal for microRNA-221 (miR-221) RNA-binding protein polypyrimidine tract-binding (PTB) posttranscriptional AdipoR1 during differentiation obesity. RNA-immunoprecipitation luciferase reporter assays illustrated that both PTB miR-221 bind AdipoR1-3'UTR cooperatively inhibit translation. Depletion or...
Ultraviolet (UV) light affects endocrinological and behavioral aspects of sexuality via an unknown mechanism. Here we discover that ultraviolet B (UVB) exposure enhances the levels sex-steroid hormones sexual behavior, which are mediated by skin. In female mice, UVB increases hypothalamus-pituitary-gonadal axis hormone levels, resulting in larger ovaries; extends estrus days; anti-Mullerian (AMH) expression. also responsiveness attractiveness females male-female interactions. Conditional...
Patients with Laron syndrome (LS; primary GH insensitivity) caused by molecular defects of the receptor gene, are characterized dwarfism, profound obesity, and hyperlipidemia. The aim current study was to evaluate adiponectin levels in LS, as obesity is known be associated low adiponectin.We studied nine untreated LS adult patients (5 males, 4 females) six girls receiving once-daily treatment IGF1. Total high weight (HMW) levels, multimers distribution, metabolic indices were analyzed serum...
Several lines of evidence suggest that estradiol influences the course schizophrenia, and a previous randomized controlled trial demonstrated transdermal improved symptoms in female patients childbearing age. However, many initial positive findings schizophrenia research are not later replicated.To independently replicate results effect on women age.An 8-week randomized, placebo-controlled performed Republic Moldova between December 4, 2015, July 29, 2016, among 200 premenopausal aged 19 to...
Anorexia nervosa (AN) is associated with profound changes in glucose homeostasis, activity of the GH-IGF-1 axis, and adipose tissue, bone, protein metabolism. We aimed to characterize transition from catabolic anabolic state during nutritional rehabilitation female adolescent inpatients AN. The study comprised 41 patients (aged 15.6±1.6 years). Blood samples were obtained at time admission, upon attainment target weight. A subgroup 18 also had blood early refeeding period. Changes BMI...