A5057013466- Cocoa and Sweet Potato Agronomy
- Phytoplasmas and Hemiptera pathogens
- Hemoglobinopathies and Related Disorders
- RNA modifications and cancer
- Biofuel production and bioconversion
- Plant-Microbe Interactions and Immunity
- Plant Pathogenic Bacteria Studies
- Banana Cultivation and Research
- Erythrocyte Function and Pathophysiology
- Coffee research and impacts
- Genomics and Phylogenetic Studies
- Gene expression and cancer classification
- Epigenetics and DNA Methylation
- Plant Disease Resistance and Genetics
- Bone and Joint Diseases
- Research on Leishmaniasis Studies
- Soybean genetics and cultivation
- Phytochemical compounds biological activities
- Plant responses to water stress
- Studies on Chitinases and Chitosanases
- Advances in Cucurbitaceae Research
- Central Venous Catheters and Hemodialysis
- Healthcare Regulation
- Insect symbiosis and bacterial influences
- Sugarcane Cultivation and Processing
Hospitais da Universidade de Coimbra
2023
Centro Nacional de Processamento de Alto Desempenho em São Paulo
2019
Universidade Estadual de Campinas (UNICAMP)
2006-2017
Bioethanol is a biofuel produced mainly from the fermentation of carbohydrates derived agricultural feedstocks by yeast Saccharomyces cerevisiae . One most widely adopted strains PE-2, heterothallic diploid naturally adapted to sugar cane process used in Brazil. Here we report molecular genetic analysis PE-2 (JAY270), and complete genome sequence haploid derivative (JAY291). The JAY270 highly heterozygous (∼2 SNPs/kb) has several structural polymorphisms between homologous chromosomes. These...
Coffee is one of the most valuable agricultural commodities and ranks second on international trade exchanges. The genus Coffea belongs to Rubiaceae family which includes other important plants. contains about 100 species but commercial production based only two species, arabica canephora that represent 70 % 30 total coffee market, respectively. Brazilian Genome Project was designed with objective making modern genomics resources available scientific community, working different aspects...
Sugarcane (Saccharum spp.) is one of the most important crops in world. Drought stress a major abiotic factor that significantly reduces sugarcane yields. However gene network mediates plant responses to water remains largely unknown several crop species. Although microRNAs mediate post-transcriptional regulation during have been described other species, role drought has not studied. The objective this work was identify miRNAs are differentially expressed under and correlate expression with...
Abstract Witches’ broom disease (WBD), caused by the hemibiotrophic fungus Moniliophthora perniciosa, is one of most devastating diseases Theobroma cacao, chocolate tree. In contrast to other interactions, WBD biotrophic stage lasts for months and responsible distinctive symptoms disease, which comprise drastic morphological changes in infected shoots. Here, we used dual RNA-seq approach simultaneously assess transcriptomes cacao M. perniciosa during their peculiar interaction. Infection...
The basidiomycete Moniliophthora roreri is the causal agent of Frosty pod rot (FPR) disease cacao (Theobroma cacao), source chocolate, and FPR one most destructive diseases this important perennial crop in Americas. This hemibiotroph infects only pods has an extended biotrophic phase lasting up to sixty days, culminating plant necrosis sporulation fungus without formation a basidiocarp. We sequenced assembled 52.3 Mb into 3,298 contigs that represent M. genome. Of 17,920 predicted open...
We present the sequencing and annotation of Leishmania (Leishmania) amazonensis genome, an etiological agent human cutaneous leishmaniasis in Amazon region Brazil. L. (L.) shares features with mexicana but also exhibits unique characteristics regarding geographical distribution clinical manifestations lesions (e.g. borderline disseminated leishmaniasis). Predicted genes were scored for orthologous gene families conserved domains comparison other pathogenic spp. Carboxypeptidase,...
Moniliophthora perniciosa is a hemibiotrophic fungus that causes witches' broom disease (WBD) in cacao. Marked dimorphism characterizes this fungus, showing monokaryotic or biotrophic phase symptoms and later dikaryotic saprotrophic phase. A combined strategy of DNA microarray, expressed sequence tag, real-time reverse-transcriptase polymerase chain reaction analyses was employed to analyze differences between these two fungal stages vitro. In all, 1,131 putative genes were hybridized with...
Summary Members of the pathogenesis‐related protein 1 ( PR ‐1) family are well‐known markers plant defence responses, forming part arsenal secreted proteins produced on pathogen recognition. Here, we report identification two cacao T heobroma L .) ‐1s that fused to transmembrane regions and serine/threonine kinase domains, in a manner characteristic receptor‐like kinases RLKs ). These TcPR ‐1f ‐1g) were named ‐1 receptor RK s). Phylogenetic analysis from indicated s originated fusion between...
The Genosoja consortium is an initiative to integrate different omics research approaches carried out in Brazil. Basically, the aim of project improve plant by identifying genes involved responses against stresses that affect domestic production, like drought stress and Asian Rust fungal disease. To do so, generated several types sequence data using methodologies, most them sequenced next generation sequencers. initial stage highly dependent on bioinformatics analysis, providing suitable...
Summary Hydroxycarbamide (HC) (or hydroxyurea) has been reported to increase fetal haemoglobin levels and improve clinical symptoms in sickle cell anaemia (SCA) patients. However, the complete pathway by which HC acts remains unclear. To study mechanisms involved action of HC, global gene expression profiles were obtained from bone marrow cells a SCA patient before after treatment using serial analysis expression. In comparison both profiles, 147 differentially expressed transcripts...
Genome projects, both genomic DNA and ESTs (cDNA), generate a large amount of information, demanding time well-structured bioinformatics laboratory to manage these data. These genome projects use information available in heterogeneous formats from different sources. The heterogeneity this as well the absence world consensus pattern, make integration data difficult task. At same time, sub-tasks, such microarray analyses are very complex. This creates demand for development creative solutions...
Summary Beta‐thalassaemia (BT) is classified according to blood transfusion requirement as minor (BTMi), intermedia (BTI) and major (BTM). BTM the most severe form, requiring regular transfusions while need only occasional in BTI. Differential gene expression between patients has not been assessed so far. Here, we evaluated global profiles during differentiation of human erythroid cells two carrying same mutation [ CD39 , (C → T)], though displaying different phenotypes (BTI BTM)....
In the northern Brazilian region, especially in state of Pará, small producers, so-called flour houses, transform cassava (Manihot esculenta Crantz) into products such as flours (white, yellow and water flour) starch which are widely consumed country.This project aimed to characterize technological physicochemical characteristics roots products.White, yellow, tapioca presented content moisture ashes within limits stipulated by legislation.All analyzed showed low levels protein fats,...