A5072804598- Nerve injury and regeneration
- Spinal Cord Injury Research
- Neurogenesis and neuroplasticity mechanisms
- Orthopedic Surgery and Rehabilitation
- Spine and Intervertebral Disc Pathology
- Peripheral Nerve Disorders
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- Medical Research and Treatments
- Pluripotent Stem Cells Research
- Electrospun Nanofibers in Biomedical Applications
- Osteoarthritis Treatment and Mechanisms
- Mesenchymal stem cell research
- Gout, Hyperuricemia, Uric Acid
- Bone health and osteoporosis research
- Tissue Engineering and Regenerative Medicine
- Shoulder Injury and Treatment
- Lower Extremity Biomechanics and Pathologies
- Epigenetics and DNA Methylation
- Nerve Injury and Rehabilitation
- Bone Metabolism and Diseases
- Bone and Joint Diseases
- Anesthesia and Pain Management
- Spinal Fractures and Fixation Techniques
Second Affiliated Hospital of Guangzhou Medical University
2024-2025
Guangzhou Medical University
2023-2025
Tianjin Medical University General Hospital
2014-2024
Ningbo University
2021-2023
Ningbo First Hospital
2023
Peking University People's Hospital
2023
Peking University
2023
Tianjin Medical University
2011-2018
Schwann cells (SCs) are the main glial of peripheral nervous system, which can promote neural regeneration. Grafting autologous SCs is one well-established and commonly performed procedures for nerve repair. With aim to improve clinical condition patients with spinal cord injury (SCI), a program grafting activated (AASCs), as well series appropriate neurorehabilitation programs, was employed achieve best therapeutic effects. We selected six who had history SCI before transplantation. At...
Spinal cord injury (SCI) is a traumatic disease of the central nervous system, accompanied with high incidence and disability rate. Tissue engineering scaffold can be used as therapeutic systems to provide effective repair for SCI.In this study, novel tissue has been synthesized in order explore effect nerve on SCI.Polycaprolactone (PCL) scaffolds loaded actived Schwann cells (ASCs) induced pluripotent stem -derived neural (iPSC-NSCs), combined cell transplantation strategy, were prepared...
Patients with spinal cord injuries can develop severe neurological damage and dysfunction, which is not only induced by primary but also secondary injuries. As an evolutionarily conserved pathway of eukaryotes, the JAK‑STAT associated cell growth, survival, development differentiation; activation has been previously reported in central nervous system injury. The directly neurogenesis glia scar formation injury region. Following axon, overexpression STAT3 exhibited specifically protecting...
Osteoporosis (OP) is an aging-related disease that the main etiology of fragility fracture. Qing'e Pill (QEP) a mixture traditional Chinese medicine (TCM) consisting Eucommia ulmoides Oliv., Psoralea corylifolia L., Juglans regia and Allium sativum L. QEP has anti-osteoporosis function, but underlying mechanism remains unclear. In this study, online databases were employed to determine chemical compounds potential target genes in osteoporosis. Potential pathways associated with defined by...
Post-traumatic related limb osteomyelitis (PTRLO) is a complex bone infection. Currently, there are no available microbial data on national scale that can guide appropriate antibiotic selection, and explore the dynamic changes in dominant pathogens over time. This study aimed to conduct comprehensive epidemiological analysis of PTRLO China.The was approved by Institutional Research Board (IRB), 3526 patients were identified from 212 394 traumatic fracture at 21 hospitals between 1 January...
Abstract Spinal cord injury (SCI) is a severe neurological disorder that causes impairment and disability. Neural stem/progenitor cells (NS/PCs) derived from induced pluripotent stem (iPSCs) represent promising cell therapy strategy for spinal regeneration repair. However, iPSC-derived NS/PCs face many challenges issues in SCI therapy; one of the most significant epigenetic regulation factors influence this mechanism. Epigenetics refers to gene expression function by DNA methylation, histone...
Aim: We aim to explore the repair effect of combined cell therapy using activated Schwann cells (ASCs) and bone mesenchymal stem (BMSCs) in traumatic spinal cord injury (SCI) rats. Materials & methods: ASCs BMSCs were used for transplantation treat acute SCI rats, both which can be obtained from patients. by prior ligation saphenous nerve flush marrow cavity with Dulbecco's modified Eagle's medium solution. Our experiment vitro confirmed that promoted differentiate into mature neural cells....
Spinal cord injury (SCI) is a severe central nervous system disorder with limited treatment options. While autophagy plays protective role in neural repair, its regulatory mechanisms SCI remain unclear. Actin-like protein 6A (Actl6a) influences cell fate and development, yet specific repair not well understood. This study investigates Actl6a's function regulating apoptosis via the transcription factor Sox2 SCI. aims to determine if Actl6a promotes survival post-SCI by autophagy-related genes...
With laminectomy being widely accepted as the treatment for lumbar disorders, epidural fibrosis (EF) is a common complication both patients and surgeons alike. Currently, EF thought to cause recurrent postoperative pain after or discectomy. Angelica sinensis traditional Chinese medicine which has shown anti-inflammatory, antifibrotic, antiproliferative properties. The object of this study was investigate effects on prevention post-laminectomy formation in rat model. A controlled...
N6-methyladenosine (m6A) is one of the most plentiful internal RNA modifications, especially in eukaryotic messenger (mRNA), which plays pivotal roles regulation mRNA life cycle and nerve development. However, m6A methylation pattern peripheral nervous injury (PNI) has not been investigated. In this study, sciatic samples were collected from 7 days after (SNI) control rats. Quantitative real-time PCR demonstrated that m6A-related methyltransferase/demethylase genes remarkably upregulated SNI...
This study aims to find the difference of genomewide DNA methylation in Schwann cells (SCs) before and after peripheral nerve system (PNS) injury by Methylated Immunoprecipitation Sequencing (MeDIP-Seq) seek meaningful differentially methylated genes related repairment injured PNS. SCs harvested from sciatic were named as activated (ASCs), ones brachial plexus normal (NSCs). Genomic ASCs NSCs isolated MeDIP-Seq was conducted. Differentially regions discovered analyzed bioinformatic methods....
Abstract Nerve damage can lead to movement and sensory dysfunction, with high morbidity disability rates causing severe burdens on patients, families, society. DNA methylation is a kind of epigenetics, great number previous studies have demonstrated that plays an important role in the process nerve regeneration remodeling. However, compared central nervous system, peripheral system shows stronger recovery after injury, which related complex microenvironment epigenetic changes occurring at...
The costs of spinal cord injury and its complications are high in personal, social financial terms. Complications include bladder cancer, for which the risk is 16-28 times higher than that general population, There currently little consensus regarding cause this discrepancy. As microRNAs stable biomarkers potential therapeutic targets present study aimed to explore underlying mechanisms phenomenon by examining changes microRNAome. Rats were used produce models injury. Microarrays...