A5100612734- Foot and Ankle Surgery
- Cancer-related molecular mechanisms research
- Metabolomics and Mass Spectrometry Studies
- Circular RNAs in diseases
- Sports injuries and prevention
- Orthopedic Surgery and Rehabilitation
- Photosynthetic Processes and Mechanisms
- Orthopaedic implants and arthroplasty
- Inflammasome and immune disorders
- Bone Metabolism and Diseases
- Bone Tissue Engineering Materials
- Hip and Femur Fractures
- Genomics and Phylogenetic Studies
- Escherichia coli research studies
- Additive Manufacturing and 3D Printing Technologies
- Hip disorders and treatments
- Bone health and osteoporosis research
- Ferroptosis and cancer prognosis
- Microbial Metabolic Engineering and Bioproduction
- Musculoskeletal synovial abnormalities and treatments
- Tendon Structure and Treatment
- Light effects on plants
- Bone fractures and treatments
- Surface Modification and Superhydrophobicity
- Heme Oxygenase-1 and Carbon Monoxide
Guiyang University
2022-2025
Nanjing Medical University
2001-2025
Union Hospital
2024
Huazhong University of Science and Technology
2021-2024
First Affiliated Hospital of Chengdu Medical College
2020-2024
Chengdu Medical College
2021-2024
Albert Einstein College of Medicine
2020-2024
West China Hospital of Sichuan University
2017-2023
Sichuan University
2017-2023
Academic Degrees & Graduate Education
2022
The complexity of repairing large segment defects and eradicating residual tumor cell puts the osteosarcoma clinical management challenging. Current biomaterial design often overlooks crucial role precisely regulating innervation in bone regeneration. Here, we develop a Germanium Selenium (GeSe) co-doped polylactic acid (PLA) nanofiber membrane-coated tricalcium phosphate bioceramic scaffold (TCP-PLA/GeSe) that mimics bone-periosteum structure. This biomimetic offers dual functionality,...
Epstein-Barr virus (EBV) is associated with several types of lymphomas and epithelial tumors including Burkitt's lymphoma (BL), HIV-associated lymphoma, posttransplant lymphoproliferative disorder, nasopharyngeal carcinoma. EBV nuclear antigen 1 (EBNA1) expressed in all required for latency transformation. EBNA1 initiates latent viral replication B cells, maintains the genome copy number, regulates transcription other EBV-encoded genes. These activities are mediated through ability to bind...
Abstract Repair of critical bone defects is a challenge in the orthopedic clinic. 3D printing an advanced personalized manufacturing technology that can accurately shape internal structures and external contours. In this study, composite scaffolds polylactic acid (PLA) nano-hydroxyapatite (n-HA) were manufactured by fused deposition modeling (FDM) technique. Equal mass PLA n-HA uniformly mixed to simulate organic inorganic phases natural bone. The suitability was evaluated material...
Post-traumatic related limb osteomyelitis (PTRLO) is a complex bone infection. Currently, there are no available microbial data on national scale that can guide appropriate antibiotic selection, and explore the dynamic changes in dominant pathogens over time. This study aimed to conduct comprehensive epidemiological analysis of PTRLO China.The was approved by Institutional Research Board (IRB), 3526 patients were identified from 212 394 traumatic fracture at 21 hospitals between 1 January...
Atomic resolution RNA structures are being published at an increasing rate. It is common to find a modest number of non-canonical base pairs in these addition the usual Watson–Crick pairs. This database summarizes occurrence rare accordance with standard nomenclature. The database, http://prion.bchs.uh.edu/ , contains infor-mation such as sequence context, sugar pucker conformation, anti/syn conformations, chemical shift, pKa values, melting temperature and free energy. Of 29 anticipated two...
Large bone defects caused by congenital defects, infections, degenerative diseases, trauma, and tumors often require personalized shapes rapid reconstruction of the tissue. Three-dimensional (3D)-printed tissue engineering scaffolds exhibit promising application potential. Fused deposition modeling (FDM) technology can flexibly select prepare printed biomaterials design fabricate bionic microstructures to promote large defect repair. FDM-3D printing was used polylactic acid (PLA)/nano...
Curcumin (Cum), the principal polyphenolic curcuminoid, obtained from turmeric rhizome Curcuma longa, is recently reported to have potential antitumor effects in vitro and vivo. Docetaxel (Doc) considered as first-line chemotherapy for treatment of non-small cell lung cancer. Here we report first time that Cum could synergistically enhance vivo efficacy Doc against In current study, combination index (CI) calculated both studies determine interaction between Doc. cytotoxicity test,...
The Central Carbon Metabolic Flux Database (CeCaFDB, available at http://www.cecafdb.org) is a manually curated, multipurpose and open-access database for the documentation, visualization comparative analysis of quantitative flux results central carbon metabolism among microbes animal cells. It encompasses records more than 500 distributions 36 organisms includes information regarding genotype, culture medium, growth conditions other specific gathered from hundreds journal articles. In...
Diabetes mellitus is an important public health problem worldwide. Insulin deficiency caused by pancreatic β cell dysfunction pathogenic factor of diabetes mellitus. This study evaluated whether empagliflozin (EMPA) protects the pancreas from mellitus-induced injury downregulating nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3)/caspase-1/Gasdermin D (GSDMD) pyroptosis-related inflammasome pathway in vitro and vivo. In vivo, animals were separated into blank control...
Abstract Since the identification of first case pneumonia unknown cause in 2019, COVID‐19 pandemic has spread globe for over 3 years. As most populous country world, China's disease prevention policies and response plans concern health country's 1.4 billion people beyond. During course pandemic, scientific research been accumulated given evidence‐based support to official guidance management. The National Health Commission China have compiled, published, updated a total 10 versions...
Differential expression of non-coding RNA after traumatic spinal cord injury (TSCI) is closely related to the pathophysiological process. The purposes this study were systematically profile and characterize circular (circRNA) in lesion epicenter tissues TSCI, predict structure potential function regulatory circRNA/miRNA network. Forty-eight C57BL/6 mice randomly equally assigned two groups: one subjected TSCI at T8–10 with an Allen's drop impactor, a second laminectomy without TSCI. Spinal...
Abstract Gene variants associated with longevity are also protection against cognitive decline, dementia and Alzheimer's disease, suggesting that common physiologic pathways act at the interface of function. To test hypothesis in genes implicated function may promote exceptional longevity, we performed a comprehensive 3‐stage study to identify functional longevity‐associated ~700 candidate up 450 centenarians 500 controls by target capture sequencing analysis. We found an enrichment nPKC...
Background Polygenic risk scores (PRSs) have been extensively developed for cancer prediction in European populations, but their effectiveness the Chinese population remains uncertain. Methods and findings We constructed 80 PRSs 13 most common cancers using seven schemes evaluated these 100,219 participants from China Kadoorie Biobank (CKB). The optimal with highest discriminatory ability were used to define genetic risk, site-specific cross-cancer associations assessed. modeled 10-year...
Background: Cuscuta australis R. Br. is a parasitic herbaceous plant that obtains nutrients by forming specialized structures called haustoria to invade host plants. Methods: In this study, we elucidated the differences in gene expression regulation and metabolic characteristics between Glycine max (Glycine (L.) Merr. Var Williams) through comprehensive transcriptomic metabolomic analyses. Results: The results demonstrated significant features haustorium distal stem segments. differentially...
The spinal cord rarely repairs itself when damaged; however, methods for encouraging nerves to regrow are on the horizon. Although circular RNAs (circRNAs) contribute various biological processes, including neuronal their functions in subacute phase of injury (SCI) have not been elucidated. In this study, we identified a novel circRNA, named CircPlek, with increased expression tissues after SCI.We predicted regulatory relationship between CircPlek and miR-135b-5p, which showed most obvious...
Objective To describe the demographic characteristics, risk factors, and bacterial resistance of fracture-related infection (FRI) long bones extremities. Materials Methods This single-center study retrospectively evaluated patients with FRI extremities at West China Hospital between January 2012 December 2017, analyzed distribution pathogenic bacteria, drug resistance. Results Among 9,900 patients, 535 (5.4%) were diagnosed FRI. The most common site was tibiofibular (298, 55.7%), 424 cases...