A5101650148- Antibiotic Resistance in Bacteria
- Genomics and Phylogenetic Studies
- Mycobacterium research and diagnosis
- Reproductive System and Pregnancy
- Liver physiology and pathology
- Pneumonia and Respiratory Infections
- Enterobacteriaceae and Cronobacter Research
- Chromosomal and Genetic Variations
- Genomic variations and chromosomal abnormalities
- Pneumocystis jirovecii pneumonia detection and treatment
- Chronic Myeloid Leukemia Treatments
- Anesthesia and Neurotoxicity Research
- Bacterial biofilms and quorum sensing
- Skin and Cellular Biology Research
- Heme Oxygenase-1 and Carbon Monoxide
- Connective Tissue Growth Factor Research
- Coronary Interventions and Diagnostics
- Dental Health and Care Utilization
- Burkholderia infections and melioidosis
- Metabolomics and Mass Spectrometry Studies
- Chemokine receptors and signaling
- Studies on Chitinases and Chitosanases
- Cancer, Stress, Anesthesia, and Immune Response
- Hormonal Regulation and Hypertension
- Culinary Culture and Tourism
Northwest A&F University
2025
Peking University People's Hospital
2018-2023
Peking University
2018-2023
Southern Medical University
2021
Nanfang Hospital
2021
The People's Hospital of Guangxi Zhuang Autonomous Region
2021
Nanjing Medical University
2020
Xiaomi (China)
2010
Since its initial release in 2001, the human reference genome has undergone continuous improvement quality, and recently released telomere-to-telomere (T2T) version - T2T-CHM13 reaches highest level of continuity accuracy after 20 years effort by working on a simplified, nearly homozygous hydatidiform mole cell line. Here, to provide an authentic complete diploid for Han Chinese, largest population world, we assembled male Chinese individual, T2T-YAO, which includes T2T assemblies all 22 + X...
Bacterial tolerance, especially in Staphylococcus aureus (S. aureus), may arise under intermittent antibiotic regimens and act as a stepping stone toward resistance development. However, the transition from tolerance to its contributing factors remain poorly understood. This study explores role of efflux pump gene abcA this process. mutants (overexpression, knockout, complementation) were constructed via homologous recombination. These strains subjected 21 cycles exposure oxacillin at 20×...
Abstract Since its initial release in 2001, the human reference genome has been continuously improved both continuity and accuracy, recently-released telomere-to-telomere version—T2T-CHM13—reaches top quality after 20 years of effort. However, T2T-CHM13 does not represent an authentic diploid genome, but rather one derived from a simplified, nearly homozygous hydatidiform mole cell line. To address this limitation provide alternative pertinent to Chinese population, largest ethnic group...
Accurate differentiation between Pneumocystis jirovecii (Pj) infection and colonization is crucial for effective treatment.
Objective: To observe the therapeutic effects and related mechanism of hemin on progression hepatic fibrosis in rats. Methods: Sixty male Wistar rats were randomly divided into normal control group, 4-week model 6-week inhibitor zinc protoporphyrin-IX (ZnPP-IX) intervention group group. Hemin complex liver was intraperitonealy administered ZnPP-IX or every other day for 2 weeks from fourth week. The mRNA expression HO-1, α-smooth muscle actin (α-SMA) nuclear factor-κB (NF-κB) tissue detected...
Abstract Background: Opportunistic pathogens are important for clinical practice as they often cause antibiotic-resistant infections. However, little is documented many emerging opportunistic and their biological characteristics. Here, we isolated a strain of extended-spectrum β-lactamase-producing Enterobacteriaceae from patient with biliary tract infection. We explored the genomic characteristics this to provide new evidence detailed information about co-infection may cause. Results: The...
Abstract Background T helper (Th) cell cytokine imbalances have been associated with the pathophysiology of chronic obstructive pulmonary disease (COPD), including Th1/Th2 and Th17/Treg paradigms. Clarifying profiles during COPD acute exacerbation (AE) their relationships clinical manifestations would help in understanding pathogenesis improve management.Methods Patients admitted to hospital AEs from January 2017 August were included this study, follow-up was conducted after discharge (every...
Objective: To investigate the interference of daratumumab on immunofixation electrophoresis after treating plasma cell diseases and methods to eliminate interference. Methods: Serum samples eight patients with treated in Peking University People's Hospital from April 2020 March 2021 were collected for standard Hydrashift 2/4 assay. Results: After treatment, 81.3% (13/16) showed drug-induced monoclonal antibodies (IgG-κ) . The without bands related individual differences, administration...
Objective To investigate the effects of fluoxetine and pyrrolidine dithidarbamate(PDTC) on lipopolysaccharide(LPS)-induced interleukine-6(IL-6) release in cultured rat astrocytes. Methods The purified astrocytes were 48-well tissue culture plate classified into control group, LPS group PDTC group.Control as usual, with or at different concentrations for 48 hours, then Fluoxetine incubated 1ug/ml 24 hours. Finally, levels IL-6 cell supernatant detected by enzymatic linked immunosorbent...
Staphylococcus lugdunensis (S. lugdunensis) is a coagulase-negative comprising the normal skin microbiota, primarily colonizing lower abdomen and extremities.[1]S. has attracted substantial attention in recent years since discovery of lugdunin by Zipperer et al[2] 2016. Lugdunin secondary metabolite synthesized non-ribosomal peptide synthetase (NRPS) that inhibits growth various gram-positive bacteria, including methicillin-resistant S. aureus (MRSA),[2] suggesting its potential as an...
Objective To investigate the effects of fluoxetine on viability and lipopolysaccharide (LPS)-induced TNF-α release primary cultured rat astrocytes. Methods The cells were plated 96-well tissue culture plates treated with (5, 10, 20, 40)μΜ for 24 hours, MTT method was used to measure cell viability. The 48-well plates, sequentially 1μg/ml LPS , enzymatic linked immunosorbent assay(ELISA) detect level supernatant. Results Compared control group(OD value: 0.20±0.017), at dose 20μΜ,...
目的 探讨多层螺旋CT回顾性心电门控冠状动脉重建的最佳R-R时相,评价多层螺旋CT冠状动脉重建的临床应用价值.方法对20例拟诊冠心病患者多层螺旋CT扫描后,利用回顾性心电门控重建出37.5%、50.0%、62.5%、75.0%R-R时相的横断面图像.然后进行冠状动脉容积重建及仿真血管内窥镜重建,分析不同R-R时相各支冠状动脉的显示情况.以选择性冠状动脉造影结果为对照,评价多层螺旋CT冠状动脉重建图像诊断冠状动脉≥50%管径狭窄的临床应用价值.结果左前降支、左回旋支和右冠状动脉重建的最佳时相为50.0%和62.5%R-R时相;多层螺旋CT冠状动脉重建图像诊断冠状动脉≥50%管径狭窄的敏感度、特异度、阳性预测值、阴性预测值和诊断正确率分别为91.7%、83.3%、28.2%、99.3%和83.9%.结论选择回顾性心电门控最佳R-R时相重建冠状动脉可以最大限度减轻心脏运动伪影,提高图像质量;多层螺旋CT冠状动脉重建图像具有很高的敏感度和阴性预测值,可以作为选择性冠状动脉造影前的筛选检查.
Abstract Background Opportunistic pathogens are important for clinical practice as they often cause antibiotic-resistant infections. However, little is documented many emerging opportunistic and their biological characteristics. Here, we isolated a novel species strain of extended-spectrum β-lactamase-producing Enterobacteriaceae from patient with biliary tract infection. We explored the genomic characteristics this to provide new evidence detailed information about co-infection may cause....
Abstract Background: This study aimed to characterize the lipidomic responses community-acquired pneumonia (CAP), and validate effectiveness of these lipids as indicators severity CAP well risk death in severe CAP.Methods: Lipidomic profiles serum were generated using ultra high-performance liquid chromatography with tandem mass spectrometry (UHPLC-MS/MS). Principal component analysis (PCA) supervised orthogonal partial least squares discriminant (OPLS-DA) was implemented distinguish between...
Abstract Opportunistic pathogens are important for clinical practice as they often cause antibiotic resistant infections. However, little is documented many emerging opportunistic and their biological characteristics. Here, we isolated a novel species of extended-spectrum β-lactamase-producing Enterobacteriaceae from patient biliary tract infection. The isolate grows very slowly but confers strong protection the co-infected cephalosporin-sensitive Klebsiella pneumonia . As initial laboratory...
Abstract Background Opportunistic pathogens are important for clinical practice as they often cause antibiotic-resistant infections. However, little is documented many emerging opportunistic and their biological characteristics. Here, we isolated a novel species strain of extended-spectrum β-lactamase-producing Enterobacteriaceae from patient with biliary tract infection. And explored the genomic characteristics this to provide new evidence detailed information about co-infection may cause....