A5100394973- Genomic variations and chromosomal abnormalities
- Ginseng Biological Effects and Applications
- Genomics and Phylogenetic Studies
- Protein Degradation and Inhibitors
- Forensic and Genetic Research
- Plant Micronutrient Interactions and Effects
- Seed Germination and Physiology
- Marine Ecology and Invasive Species
- Plant Stress Responses and Tolerance
- Chromosomal and Genetic Variations
- Mycotoxins in Agriculture and Food
- Wheat and Barley Genetics and Pathology
- Plant Molecular Biology Research
- Gut microbiota and health
- Advanced Data Processing Techniques
- Aortic aneurysm repair treatments
- Polysaccharides and Plant Cell Walls
- Colorectal Cancer Treatments and Studies
- Plant tissue culture and regeneration
- Plant and Fungal Interactions Research
- Protist diversity and phylogeny
- Animal Virus Infections Studies
- Microbial Community Ecology and Physiology
- Hedgehog Signaling Pathway Studies
- Isotope Analysis in Ecology
Chinese Academy of Sciences
2002-2025
Wuhan University
2022-2025
Renmin Hospital of Wuhan University
2025
Chengdu Institute of Biology
2002-2025
Nanchang University
2022-2024
Sichuan University
2022-2024
Southern Medical University
2022-2024
Beijing Institute of Genomics
2013-2023
Wellcome Sanger Institute
2022-2023
Henan Agricultural University
2022-2023
Since its initial release in 2001, the human reference genome has undergone continuous improvement quality, and recently released telomere-to-telomere (T2T) version - T2T-CHM13 reaches highest level of continuity accuracy after 20 years effort by working on a simplified, nearly homozygous hydatidiform mole cell line. Here, to provide an authentic complete diploid for Han Chinese, largest population world, we assembled male Chinese individual, T2T-YAO, which includes T2T assemblies all 22 + X...
Abstract Background Ginseng is an important medicinal herb in Asia and Northern America. The basic leucine zipper ( bZIP ) transcription factor genes play roles many biological processes plant responses to abiotic biotic stresses, such as drought stress. Nevertheless, the remain unknown ginseng. Results Here, we report 91 identified from ginseng, designated PgbZIP genes. These were alternatively spliced into 273 transcripts. Phylogenetic analysis grouped ten groups, including A, B, C, D, E,...
ABSTRACT Sucrose nonfermenting‐1 related protein kinase (SnRK2) is an important family of stress signalling genes to nutrient utilisation, metabolic regulations and responsive external stressors. In this work, all three copies TaSnRK2.9 were extracted from wheat ( Triticum aestivum L.) chromosomes 5A, 5B 5D. To elucidate the function TaSnRK2.9s , cloned, functional characterisation was performed under normal abiotic conditions. Agrobacterium‐mediated technique used transform wild‐type (WT)...
Abstract Aortic aneurysm and dissection (AAD) is a multifaceted condition characterized by significant genetic predisposition considerable contribution to cardiovascular-related mortality. Previous studies have suggested that AAD subtypes share similar mechanisms, however, these investigated the separately. Here, we performed large genome-wide association study (GWAS) meta-analysis for combining its subtypes, including 11,148 cases 708,468 controls of European ancestry. We identified 24...
Abstract Background Emerging findings highlighted the associations of mental illness to nutrition and dysbiosis in intestinal microbiota, but underlying mechanisms, especially schizophrenia (SZ), remain unclarified. Methods We conducted a case-control study SZ patients (case control=100:52) by performing sequencing gut metagenome; measurement fecal plasma non-targeted metabolome; including short-, medium-, long-chain fatty acids; targeted metabolites, along with recorded details daily...
The vast population of bacterial phages or viruses (virome) plays pivotal roles in the ecology human microbial flora and health conditions. Obstacles, including poor viral sequence inference, strain-sensitive virus-host relationship, high diversity among individuals, hinder in-depth understanding virome. We conducted longitudinal studies virome based on constructing a high-quality personal reference metagenome (PRM). By applying long-read sequencing for representative samples, we could build...
Abstract Since its initial release in 2001, the human reference genome has been continuously improved both continuity and accuracy, recently-released telomere-to-telomere version—T2T-CHM13—reaches top quality after 20 years of effort. However, T2T-CHM13 does not represent an authentic diploid genome, but rather one derived from a simplified, nearly homozygous hydatidiform mole cell line. To address this limitation provide alternative pertinent to Chinese population, largest ethnic group...
DNA‐STR genotyping technology has been widely used in forensic investigations. Even with such success, there is a great need to reduce the analysis time. In this study, we established new rapid 21‐plex STR typing system, including 13 CODIS loci, Penta D, E, D12S391, D2S1338, D6S1043, D19S433, D2S441 and Amelogenin loci. This system could shorten amplification time minimum of 90 min does not require DNA extraction from samples. Validation complied Scientific Working Group on Analysis Methods...
Here, we report the complete genome sequence of Glaciecola psychrophila strain 170(T), a novel species genus Glaciecola, isolated from sea ice at high-latitude Arctic locations. The consists single chromosome (5,413,691 bp) and 5,363 genes. genomics information will facilitate study physiology, cold adaptation, evolution this genus.
Abstract Human coronaviruses (CoVs) can cause respiratory infection epidemics that sometimes expand into globally relevant pandemics. All human CoVs have sister strains isolated from animal hosts and seem to an origin, yet the process of host jumping is largely unknown. RNA interference (RNAi) ancient mechanism in many eukaryotes defend against viral infections through hybridization endogenous small RNAs (miRNAs) with target sites invading RNAs. Here, we developed a method identify potential...
<title>Abstract</title> Colorectal cancer (CRC) is among the leading causes of cancer-related mortality globally. Metastatic colorectal (mCRC) with ultra-hypermutation uncommon and its underlying pathogenesis remains incompletely characterized. Additionally, response to immunotherapy in ultra-hypermutated mCRC not well defined. Here we report a unique case 33-year-old Chinese woman right-sided colon adenocarcinoma harboring somatic mutations POLE (p.A465V), MSH6 (p.G237*), MSH2 (p.T934M)...