A5100634363- RNA modifications and cancer
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- DNA Repair Mechanisms
- Biochemical and Molecular Research
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Dental Trauma and Treatments
- ECG Monitoring and Analysis
- Cytokine Signaling Pathways and Interactions
- Gestational Diabetes Research and Management
- Ubiquitin and proteasome pathways
- Pharmacological Effects and Assays
- Genomics and Chromatin Dynamics
- EEG and Brain-Computer Interfaces
- HIV/AIDS drug development and treatment
- Family and Patient Care in Intensive Care Units
- Lung Cancer Treatments and Mutations
- RNA Interference and Gene Delivery
- Health and Well-being Studies
- Stroke Rehabilitation and Recovery
- RNA Research and Splicing
- Obesity, Physical Activity, Diet
- Injury Epidemiology and Prevention
- Reproductive Biology and Fertility
Jiangnan University
2024-2025
Wuxi Fourth People's Hospital
2024-2025
Nanjing Medical University
2023-2024
National University of Defense Technology
2023
Institute of Forensic Science
2016
Second Affiliated Hospital of Soochow University
2013
Soochow University
2013
Southeast University
2012
Chongqing University of Technology
2007
Abstract Epidermal growth factor receptor‐targeted ( EGFR ‐targeted) therapies show promise for non‐small cell lung cancer (NSCLC), but they are ineffective in a third of patients who lack mutations. This underlines the need personalized treatments with wild‐type NSCLC. A genome‐wide CRISPR/Cas9 screen has identified enzyme phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase PAICS ), which is vital de novo purine biosynthesis and tumor...
Abstract Cancer cells harbor cell-intrinsic programs capable of sculpting immunogenic landscapes, yet molecular brakes that enforce immune evasion remain poorly defined. Here, we identify C9ORF50, a previously uncharacterized intrinsically disordered protein, as liquid-liquid phase separation-driven regulator RNA processing and actionable immunotherapy target. Genetic ablation C9ORF50 induces selective intron retention in spliceosome component transcripts, leading to cytoplasmic accumulation...
Birth interval is acknowledged as a significant factor affecting the health of women and their children. This study aimed to investigate relationship between time from first last birth prevalence general obesity, abdominal or both, among middle-aged postmenopausal Chinese women. cross-sectional survey examined 4,799 women, aged 45-59 years, who had at least one live birth. General obesity was assessed using body mass index (BMI), while evaluated through waist-to-hip ratio (WHR),...
Despite substantial advances that have been made in understanding the etiology of hepatocellular carcinoma (HCC), early-stage diagnosis and treatment advanced-stage HCC remain a major challenge. RNF8, an E3 ligase important for DNA damage response, has proven to facilitate progression breast lung cancer, but its role remains unclear. In this study, we find expression RNF8 is up-regulated tissues positively correlated with poor prognosis HCC. Furthermore, silencing by siRNAs attenuates...
Objective To compare the antepartum and postpartum plasma concentrations of endothelial microparticles (EMPs) in patients with pre-eclampsia those healthy control subjects normal pregnancies. Methods Plasma EMPs were measured using specific antibody labelling flow cytometry prior to delivery by caesarean section (antepartum), again at 24 h 72 postpartum. The correlations between EMP concentration mean arterial pressure (MAP), 24-h urine protein analysed. Results A total 59 60 participated...
Motor aphasia, known as Broca is a common type of aphasia. Early language rehabilitation training can maximumly improve function and have positive impact on patients′ daily life. This paper would review the aphasia characteristics, classification, diagnosis early nursing care patients. Key words: Reviews; Motor aphasia; Early training; Nursing
Abstract EGFR-targeted therapies for NSCLC have made promising progress, whereas one-third of patients do not benefit from them due to lack EGFR mutations. Therefore, personalized molecular-targeted are urgently needed wild-type patients. Genome-wide CRISPR/Cas9 screen was performed in cell lines identify NSCLC-specific essential genes as potential drug targets. As a result, PAICS identified new therapeutic target NSCLC. PAICS, an enzyme involved de novo purine biosynthesis, is closely...
<p>Figure S1 shows the expression of RNF8 in different pathological types lung cancers tissues. Figure S2 overexpression RNF8-C406S cannot improve migration potential A549 cells.</p>
<p>Figure S1 shows the expression of RNF8 in different pathological types lung cancers tissues. Figure S2 overexpression RNF8-C406S cannot improve migration potential A549 cells.</p>
EGFR-targeted therapies for NSCLC have made promising progress, whereas one-third of patients do not benefit from them due to lack EGFR mutations. Therefore, personalized molecular-targeted are urgently needed wild-type patients. To this end, a genome-wide CRISPR/Cas9 screen was conducted on cell lines identify NSCLC-specific essential genes that could serve as potential drug targets. Among the candidate genes, PAICS, an enzyme involved in de novo purine biosynthesis and closely associated...
<div>Abstract<p>RNF8 (ring finger protein 8), a RING E3 ligase best characterized for its role in DNA repair and sperm formation via ubiquitination, has been found to promote tumor metastasis breast cancer recently. However, whether RNF8 also plays other types of cancer, especially lung remains unknown. We show here that expression levels are markedly increased human tissues negatively correlated with the survival time patients. Overexpression promotes EMT process migration...
<div>Abstract<p>RNF8 (ring finger protein 8), a RING E3 ligase best characterized for its role in DNA repair and sperm formation via ubiquitination, has been found to promote tumor metastasis breast cancer recently. However, whether RNF8 also plays other types of cancer, especially lung remains unknown. We show here that expression levels are markedly increased human tissues negatively correlated with the survival time patients. Overexpression promotes EMT process migration...
The conventional classification parameters of QRS complex suffer from larger activity rang patients and lower signal to noise ratio in mobile cardiac telemonitoring system can not meet the identification needs ECG signal. Based on individual sinus heart rhythm template built with signals time window, we present semblance index extract features precisely expeditiously. Relative approximation r2 absolute error r3 are used as estimating between testing template. evaluate corresponding width...