A5104273046- Glioma Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- PI3K/AKT/mTOR signaling in cancer
- Immune cells in cancer
- Histone Deacetylase Inhibitors Research
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- RNA regulation and disease
- Cancer-related gene regulation
- Cancer therapeutics and mechanisms
- Cancer Mechanisms and Therapy
- Cystic Fibrosis Research Advances
- Pharmacogenetics and Drug Metabolism
- Pregnancy and preeclampsia studies
- Coronary Interventions and Diagnostics
- Molecular Biology Techniques and Applications
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Traditional Chinese Medicine Studies
- Cholesterol and Lipid Metabolism
- Renal and related cancers
- Photosynthetic Processes and Mechanisms
- Pancreatitis Pathology and Treatment
- Biochemical and Molecular Research
- CRISPR and Genetic Engineering
First Affiliated Hospital of Xi'an Jiaotong University
2022-2025
University of Chinese Academy of Sciences
2023-2025
Tianjin Institute of Industrial Biotechnology
2024-2025
Chinese Academy of Sciences
2023-2025
Nanjing Medical University
2023-2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024-2025
Chongqing Medical University
2024-2025
Fujian Medical University
2022-2025
Fujian Provincial Hospital
2022-2025
Sino-Danish Centre for Education and Research
2025
No study has examined the association between per- and polyfluoroalkyl substances (PFAS) exposure chronic obstructive pulmonary disease (COPD) risk. This aims to explore this relationship. enrolled 4541 individuals who had unavailable data on PFAS, COPD, covariates from NHANES 2007–2018. Serum PFAS including perfluorohexane sulfonate (PFHxS), perfluorononanoic acid (PFNA), perfluorooctanoic (PFOA), perfluorooctane sulfonic (PFOS) were analyzed, because of high detective rates. Considering...
Pancreatic ductal adenocarcinoma (PDAC) is frequently diagnosed and treated in advanced tumor stages with poor prognosis. More effective screening programs novel therapeutic means are urgently needed. Recent studies have regarded tight junction protein claudin 18.2 (CLDN18.2) as a candidate target for cancer treatment, zolbetuximab (formerly known IMAB362) has been developed against CLDN18.2. However, there few data reported thus far related to the clinicopathological characteristics of...
Abstract Epidermal growth factor receptor‐targeted ( EGFR ‐targeted) therapies show promise for non‐small cell lung cancer (NSCLC), but they are ineffective in a third of patients who lack mutations. This underlines the need personalized treatments with wild‐type NSCLC. A genome‐wide CRISPR/Cas9 screen has identified enzyme phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase PAICS ), which is vital de novo purine biosynthesis and tumor...
The aim of the study was to examine relationship between coffee, tea, caffeine consumption and risk all-cause death cardiovascular disease (CVD) in CVD population.This cohort included 626 participants aged ≥18 years old who derived from National Health Nutrition Examination Surveys (NHANES) database 2003-2006. end time follow-up 2015, with a median 113.5 (63, 133) months. defined as caused by congestive heart failure (CHF), coronary (CHD), angina pectoris, attack or stroke. Cox model...
Abstract Background Glioblastomas (GBMs) display striking dysregulation of metabolism to promote tumor growth. Glioblastoma stem cells (GSCs) adapt regions heterogeneous nutrient availability, yet dependency on de novo cholesterol biosynthesis. The transcription factor Sterol Regulatory Element-Binding Protein 2 (SREBP2) regulates biosynthesis enzymes and uptake receptors. Here, we investigate adaptive behavior GSCs under different supplies. Methods In silico analysis patient tumors...
To investigate the safety and effectiveness of retroperitoneal adrenalectomy via extra intra perinephric fat approaches to provide experience basis for resection adrenal tumors through cavity. The clinical data 284 patients undergoing in our hospital from December 2017 March 2023 were collected. basic characteristics two groups changes perioperative indicators retrospectively analyzed. A total 117 with approach (IPFA) included,and 167 (EPFA) included. estimated blood loss IPFA group (123.59...
Repurposing existing commercial diagnostic equipment to enable portable analysis of diverse targets is driving the development affordable point-of-care testing (POCT). Interestingly, we found that goat antimouse IgG could replace human chorionic gonadotropin (hCG) make T line pregnancy test strips (PTS) appear red color and accordingly synthesized a novel signal output probe, which eliminated intricate hCG covalent coupling steps, meet multiple needs expanded POCT. Given this, introduced...
Abstract Wild jujube seed protein (WJSP) as one kind of functional food material has attracted much attention due to its highly nutritive and medicinal value in anti‐inflammatory improving immunomodulatory ability. However, owing large molecular weight complex structure, biological activities WJSP were greatly limited cannot be fully utilized by the human body. Therefore, how improve bioavailability develop promising nutritious materials is a great challenge. In this work, wild hydrolysates...
Curd setting height, a critical component of plant plays an important role in ideotype construction and yield improvement cauliflower. However, the underlying mechanisms governing this trait <italic>Brassica</italic> crops remain unclear. In study, we developed two F<sub>2</sub> populations by crossing cauliflower DH line, ZAASC4101, having short main stem, with <italic>Brassica oleracea</italic> inbred lines possessing long stem. Subsequently, high-density linkage maps were constructed for...
Enzymes play a crucial role in various industrial production and pharmaceutical developments, serving as catalysts for numerous biochemical reactions. Determining the optimal catalytic temperature (Topt) of enzymes is optimizing reaction conditions, enhancing efficiency, accelerating processes. However, due to limited availability experimentally determined Topt data insufficient accuracy existing computational methods predicting Topt, there an urgent need approach predict values accurately....
Background Pseudomonas aeruginosa is a common pathogen that contributes to progressive lung disease in cystic fibrosis (CF). Genetic factors other than CF-causing CFTR (CF transmembrane conductance regulator) variations contribute ∼85% of the variation chronic P. infection age CF according twin studies, but susceptibility loci remain unknown. Our objective advance understanding genetic basis host infection. Materials and methods We conducted genome-wide association study 1037 Canadians with...
To review and critically appraise articles on prediction models for coronary artery lesions (CALs) in Kawasaki disease included PubMed, Embase, Web of Science databases from January 1, 1980, to December 23, 2021. Study screening, data extraction, quality assessment were performed by two independent reviewers, with a statistics expert resolving discrepancies. Articles that developed or validated model CALs included. The Critical Appraisal Data Extraction Systematic Reviews Prediction Modeling...
Tuberculosis (TB) remains a significant challenge for public health and is closely associated with malnutrition; however, few studies have attempted to screen malnutrition among TB patients. The study aimed evaluate the nutrition status build new nutritional screening model active TB.A retrospective, multicenter, large cross-sectional was conducted in China from 1 January 2020 31 December 2021. All included patients diagnosed pulmonary (PTB) were evaluated both by Nutrition Risk Screening...