A5100778174- Robotics and Sensor-Based Localization
- Renal and related cancers
- CRISPR and Genetic Engineering
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Plant Gene Expression Analysis
- Virus-based gene therapy research
- Viral Infectious Diseases and Gene Expression in Insects
- Pluripotent Stem Cells Research
- Circular RNAs in diseases
- Cell death mechanisms and regulation
- Advanced Image and Video Retrieval Techniques
- MicroRNA in disease regulation
- Advanced Vision and Imaging
- Endoplasmic Reticulum Stress and Disease
- Plant biochemistry and biosynthesis
- RNA modifications and cancer
- 3D Surveying and Cultural Heritage
- RNA Research and Splicing
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Plant Reproductive Biology
- Advanced SAR Imaging Techniques
- Geophysical Methods and Applications
Guizhou University
2015-2025
Nanchang University
2025
Hubei University of Chinese Medicine
2024-2025
University of Minnesota
2022-2025
Second Affiliated Hospital of Nanchang University
2025
Hunan Normal University
2015-2024
Xinjiang University
2024
National University of Defense Technology
2014-2023
Beijing University of Agriculture
2015-2023
Henan Provincial People's Hospital
2023
3D object recognition in cluttered scenes is a rapidly growing research area. Based on the used types of features, methods can broadly be divided into two categories-global or local feature based methods. Intensive has been done surface as they are more robust to occlusion and clutter which frequently present real-world scene. This paper presents comprehensive survey existing These generally comprise three phases: keypoint detection, description, matching. covers an extensive literature each...
Protein folding by the endoplasmic reticulum (ER) is physiologically critical; its disruption causes ER stress and augments disease. activates unfolded protein response (UPR) to restore homeostasis. If persists, UPR induces apoptotic cell death, but mechanisms remain elusive. Here, we report that unmitigated promoted apoptosis through cell-autonomous, UPR-controlled activation of death receptor 5 (DR5). stressors induced DR5 transcription via mediator CHOP; however, sensor IRE1α transiently...
Human embryonic stem cells (hESCs) can be maintained in vitro as immortal pluripotent but remain responsive to many differentiation-inducing signals. Investigation of the initial critical events involved differentiation induction would greatly facilitated if a specific, robust, and quantitative assay for hESCs with self-renewal potential were available. Here we describe results series experiments determine whether formation adherent alkaline phosphatase-positive (AP(+)) colonies under...
Range image registration is a fundamental research topic for 3D object modeling and recognition. In this paper, we propose an accurate robust algorithm pairwise multi-view range registration. We first extract set of Rotational Projection Statistics (RoPS) features from pair images, perform feature matching between them. The two images are then registered using transformation estimation method variant the Iterative Closest Point (ICP) algorithm. Based on algorithm, shape growing based seed...
Multiple myeloma (MM) arises from malignant immunoglobulin (Ig)-secreting plasma cells and remains an incurable, often lethal disease despite therapeutic advances. The unfolded-protein response sensor IRE1α supports protein secretion by deploying a kinase-endoribonuclease module to activate the transcription factor XBP1s. MM may co-opt IRE1α-XBP1s pathway; however, validity of as potential target is controversial. Genetic disruption or XBP1s, pharmacologic kinase inhibition, attenuated...
To explore the geographical pattern and temporal trend of autism spectrum disorders (ASD) epidemiology from 1990 to 2019, perform a bibliometric analysis risk factors for ASD.In this study, ASD was estimated with prevalence, incidence, disability-adjusted life-years (DALYs) 204 countries territories by sex, location, sociodemographic index (SDI). Age-standardized rate (ASR) annual percentage change (EAPC) were used quantify trends. Besides, study performed since 1990. Publications published...
Abstract Recombinant adeno‐associated virus (rAAV) is among the most commonly used vectors for gene therapy. It produced by transfection of HEK293 cells with three plasmids each containing vector genome including interest (GOI), helper functions, and rep cap genes replication capsid formation. To meet potential clinical needs, productivity production system needs to be enhanced. A better process characterization will further advance our insights into ways enhance productivity. Here, we...
Abstract Recombinant adeno‐associated virus (rAAV) is one of the most widely used viral vectors for gene therapy. It in very high doses treatment many diseases, making large‐scale production clinical applications challenging. We have established a synthetic biology‐based platform to construct stable cell lines, which can be induced produce rAAV2. In this study, we extended our line construction pipelines rAAV2 rAAV8, serotype whose tropism makes it attractive delivery multiple tissues. The...
AU-rich elements (ARE) present in the 3′ untranslated regions of many cytokines and immediate-early genes are responsible for targeting transcripts rapid decay. We evidence from cotransfection experiments NIH 3T3 cells that two signaling pathways, one involving phosphatidylinositol 3-kinase (PI3-K), p38 mitogen-activated protein kinase (MAPK), lead to stabilization interleukin-3 mRNA parallel. Stabilization mediated by either pathways was antagonized tristetraprolin (TTP), an AU-binding...
Global gene expression profiling was performed on murine embryonic stem cells (ESCs) induced to differentiate by removal of leukemia inhibitory factor (LIF) identify genes whose change in correlates with loss pluripotency. To appropriate time points for the analysis, dynamics pluripotency were investigated using three functional assays: chimeric mouse formation, embryoid body generation, and colony-forming ability. A rapid detected within 24 hours, very low residual activity all assays 72...
Tumor necrosis factor alpha (TNF-α) expression is regulated by transcriptional as well posttranscriptional mechanisms, the latter including control of mRNA decay through an AU-rich element (ARE) in 3′ untranslated region (UTR). Using two mutant cell lines deficient for ARE-mediated decay, we provide evidence a second element, constitutive (CDE), which also located UTR TNF-α. In stably transfected RAW 264.7 macrophages stimulated with lipopolysaccharide (LPS), CDE continues to target reporter...
Dihydrorhodamine 123 (DHR 123), 2,7-dichlorodihydrofluorescein diacetate (DCFH-DA), and dihydrorhodamine 6G 6G) were evaluated as probes for detecting cellular hydrogen peroxide levels in SPC-A-1 lung adenocarcinoma cells. Imaging techniques fluorescence-activated cell scan used the study of probe responses. Obvious green fluorescence was established after a 25-min exposure. After staining with MitoTracker Orange CM-H2TMRos (a mitochondria) abovementioned simultaneously, only DHR groups...