A5100389848- Stroke Rehabilitation and Recovery
- Chronic Lymphocytic Leukemia Research
- Prosthetics and Rehabilitation Robotics
- Advanced Mathematical Physics Problems
- Protein Degradation and Inhibitors
- HIV Research and Treatment
- Diabetic Foot Ulcer Assessment and Management
- Lower Extremity Biomechanics and Pathologies
- Acute Myeloid Leukemia Research
- Global Health Care Issues
- Health disparities and outcomes
- Cancer Immunotherapy and Biomarkers
- Balance, Gait, and Falls Prevention
- HIV/AIDS drug development and treatment
- Musculoskeletal pain and rehabilitation
- Folate and B Vitamins Research
- EEG and Brain-Computer Interfaces
- Autism Spectrum Disorder Research
- Cerebral Palsy and Movement Disorders
- Muscle activation and electromyography studies
- Insurance, Mortality, Demography, Risk Management
- Acute Ischemic Stroke Management
- Nonlinear Waves and Solitons
- Ferroptosis and cancer prognosis
- IL-33, ST2, and ILC Pathways
Peking University
2008-2025
Qufu Normal University
2025
Wuhan University
2016-2024
State Key Laboratory of Oncology in South China
2012-2024
Sun Yat-sen University
2021-2024
Sun Yat-sen University Cancer Center
2021-2024
Peking University First Hospital
2022-2024
Central Hospital of Wuhan
2023
Huazhong University of Science and Technology
2023
Sixth Affiliated Hospital of Sun Yat-sen University
2023
RG7112 is a small-molecule MDM2 antagonist. negative regulator of the tumor suppressor p53 and frequently overexpressed in leukemias. Thus, phase I study patients with hematologic malignancies was conducted.Primary objectives included determination dose safety profile RG7112. Secondary evaluation pharmacokinetics; pharmacodynamics, such as TP53-mutation status expression; preliminary clinical activity. Patients were divided into two cohorts: Stratum A [relapsed/refractory acute myeloid...
To explore the geographical pattern and temporal trend of autism spectrum disorders (ASD) epidemiology from 1990 to 2019, perform a bibliometric analysis risk factors for ASD.In this study, ASD was estimated with prevalence, incidence, disability-adjusted life-years (DALYs) 204 countries territories by sex, location, sociodemographic index (SDI). Age-standardized rate (ASR) annual percentage change (EAPC) were used quantify trends. Besides, study performed since 1990. Publications published...
Abstract Objective To quantify and compare the contribution of 306 diseases injuries to changes in health adjusted life expectancy at birth (HALE 0 ) between 1990 2013. Design Retrospective demographic analysis based on aggregated data using table technique, Sullivan method, decomposition method for differences expectancy. Setting The globe, 21 regions, 187 countries, covered Global Burden Disease Study (GBD) Main outcome measures Cause specific HALE 2013 terms mortality effect, disability...
3505 Background: Immune checkpoint inhibitors have been used in neoadjuvant setting and showed promising clinical benefits various tumors. Herein, we evaluate IBI310 plus sintilimab as treatment patients (pts) with microsatellite instability-high (MSI-H)/mismatch repair-deficient (dMMR) colorectal cancer (CRC) a randomized, open-labeled, phase Ib study. Methods: Previously untreated pts locally advanced (stage IIB-III), resectable, MSI-H/dMMR CRC were enrolled randomized to receive 1 cycle...
To examine the association between risk of neural tube defects (NTD) and maternal serum vitamin B12, folate homocysteine in a high-risk area China.A case-control study was carried out Luliang mountain Shanxi Province.A total eighty-four NTD pregnancies 110 matched controls were included study; their B12 concentrations measured by chemiluminescent immunoenzyme assay fluorescent polarisation immunoassay.Serum lower NTD-affected pregnant women than (P < 0.01). Serum higher group at less 21...
We consider the $1d$ cubic nonlinear Schr\"odinger equation with a large external potential $V$ no bound states. prove global regularity and quantitative bounds for small solutions under mild assumptions on $V$. In particular, we do not require any differentiability of $V$, make spatial decay that are weaker than those found in literature (see example \cite{Del,N,GPR}). treat both case generic non-generic potentials, some additional symmetry latter case. Our approach is based combination...
The 6-min walk distance (6MWD) and the Fugl-Meyer assessment lower-limb subscale (FMA-LE) of stroke patients provide critical evaluation standards for effect training guidance programs. However, gait typically relies on manual observation table scoring, which raises concerns about wasted manpower subjective results. To address this issue, paper proposes an intelligent rehabilitation method (IRAM) based sensor data lower limb exoskeleton robot. Firstly, feature parameters patient were...
Abstract Background Considerable socioeconomic and health inequalities have been reported in China. However, because of a lack appropriate data, limited research has conducted on variations disability-free life expectancy (DFLE) among older adults. This study aimed to use the most up-to-date disability survey data explore geographical DFLE at age 60 China identify care factors that partially account for these variations. Methods used 2006 mortality extrapolated from 1990 2000 Census national...
Objective : To investigate the efficacy and safety of a novel lower-limb exoskeletal robot, BEAR-H1 (Shenzhen Milebot Robot Technology), in locomotor function subacute stroke patients. Methods The present study was approved by ethical committee First Affiliated Hospital Nanjing Medical University (No. 2019-MD-43), registration recorded on Chinese Clinical Trial Registry with unique identifier: ChiCTR2100044475. A total 130 patients within 6 months were randomly divided into two groups: robot...
Introduction: In the context of climate change, frequency and intensity droughts in arid semi-arid areas have shown a substantially increasing trend, which inevitably affects plant survival growth. However, it is unclear what growth strategies plants subjected to drought pretreatment early life stages adopt when facing subsequent stress. Methods: Here, we conducted field experiment set up two treatments, control pretreatment, investigate effects on survival, phenology, morphology, biomass,...
Background/Aims: Biliary Atresia (BA) is a devastating pediatric liver disease and characterized by aggressive fibrosis progression. The Interleukin-33 (IL-33)/ST2 receptor signaling axis has been demonstrated to be involved in several autoimmune diseases. Since immune dysregulation contributor BA pathogenesis, we aimed investigate the role of IL-33/ST2 progression patients. Materials Methods: study included 36 patients (18 good- 18 poor-prognosis patients); 8 cholestasis infants as control...
Overweight, obesity and falls are major public health problems old people the biggest group suffering falls. 92 females were divided into overweight or (O) (68.85 ± 3.85) regular-weight (R) (67.90 4.02). Lower extremity motor capacity plantar pressure compared between two groups. The IRB approval number is 20190804. (1) Functional Movement Screen Fugl-Meyer Assessment scores in O significantly lower than R group. time to complete Timed Up Go test was longer (2) Foot flat phase, double...
A Comparative Study on Strength between American College Male and Female Students in Caucasian Asian Populations Muscle strength has been considered as a major factor sport performance, martial arts competitions, self-defense, other physical activities. The purpose of the study was to investigate potential difference muscle male female college students. results indicated that students is significantly lower than arm, upperbody chest, shoulder, leg, abdominal. Females have 37-68% males...
Introduction Health literacy is an effective strategy to promote more cost-effective use of health care services and a crucial tool for preventing the spread infectious diseases. The main objective this study was analyze changes in from 2019 2021. Methods Data were latest three-round cross-sectional studies with same design. Results Although prevalence adequate rose significantly over time, increasing 26.9% (95% CI 20.1–33.7) 34.1% (32.9–35.3) 2021, it still at relatively low level. most...
The weekly calendar planning activity (WCPA) is a performance-based assessment of executive function (EF) via cognitively-based instrumental daily life (C-IADL). This study aimed to examine the validity Chinese version WCPA in adults with stroke and explore characteristics cognitive strategy use among population. Fifty-eight hospitalized patients aged 26–82 years 53 controls completed WCPA, two neuropsychological tests (IADL) scale. Participants were subdivided into impaired group...
To examine the effects of foot dominance and body mass on plantar pressures in older women regular, overweight, obese weights.