A5014234543- Pesticide Exposure and Toxicity
- Carcinogens and Genotoxicity Assessment
- Pesticide Residue Analysis and Safety
- Animal testing and alternatives
- Intraoperative Neuromonitoring and Anesthetic Effects
- Advancements in Transdermal Drug Delivery
- Insect and Pesticide Research
- Transcranial Magnetic Stimulation Studies
- Pesticide and Herbicide Environmental Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Risk and Safety Analysis
- Dermatology and Skin Diseases
- Advanced Neuroimaging Techniques and Applications
- Effects and risks of endocrine disrupting chemicals
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurosurgical Procedures and Complications
- Reproductive biology and impacts on aquatic species
- Toxic Organic Pollutants Impact
- Radioactivity and Radon Measurements
- Spine and Intervertebral Disc Pathology
- Thermoregulation and physiological responses
- Pharmacological Effects and Assays
- Atrial Fibrillation Management and Outcomes
- History and advancements in chemistry
- Agricultural safety and regulations
Paracelsus Medizinische Privatuniversität
2021-2025
Nuremberg Hospital
2024-2025
University of Guelph
1998-2021
University of Würzburg
1999-2000
Health Canada
1979-1994
BC Centre for Disease Control
1990
Ottawa Fertility Centre
1989
Concordia University
1975
Background: Recently, the International Agency for Research on Cancer (IARC) Programme Evaluation of Carcinogenic Risks to Humans has been criticized several its evaluations, and also approach used perform these evaluations. Some critics have claimed that failures IARC Working Groups recognize study weaknesses biases Group members led inappropriate classification a number agents as carcinogenic humans.Objectives: The authors this Commentary are scientists from various disciplines relevant...
A cohort study of the mortality experience (1971-1985) male Saskatchewan farmers has been conducted. This involved linkage records almost 70,000 identified on 1971 Census Agriculture and corresponding Population to records. Pesticide exposure indices for individual farm operators year 1970 were derived from Although as a whole had no excess any specific causes death, including non-Hodgkin's lymphoma, significant dose-response relationships noted between risk lymphoma acres sprayed in with...
There is a recognized need to improve the application of epidemiologic data in human health risk assessment especially for understanding and characterizing risks from environmental occupational exposures. Although there uncertainty associated with results most studies, techniques exist characterize that can be applied weight-of-evidence evaluations characterization efforts.
Abstract Background Brain abscesses can lead to severe clinical outcomes, including death. Most studies on brain focus either patient cohorts postsurgical/posttraumatic abscesses. This study aimed assess the presentation and postoperative outcomes in a homogeneous group of patients with primary, pyogenic who underwent surgical treatment. Methods We retrospectively analyzed consecutive treated surgically at our center from 2008 2023. The primary endpoint was modified Rankin Scale (mRS) score...
Abstract Hemangioblastomas are rare, benign, highly vascularized tumors, which among other locations arise in the central nervous system. Due to tumor's dense vascularity, bleeding and interference with surrounding brain tissue vasculature have been reported. Rapid neurological deterioration due hemorrhage from a hemangioblastoma, especially spinal locations, has clinical occurred 47-year-old male patient cerebellar hemangioblastoma delayed extensive ischemia, consecutively. Initial cranial...
Dermal absorption of the 14C‐ring‐labeled phenoxy herbicides 2,4‐D [(2,4‐dichlorophenoxy)acetic acid], amine (2,4‐dichlorophenoxyacetic acid dimethyl‐amine), isooctyl ester), and 2,4,5‐T (2,4,5‐trichlorophenoxyacetic trimethylamine) was examined following topical applications to back rabbits, tail rats, forearm forehead rhesus monkeys, human volunteers. The effect three pesticide vehicles (water, acetone, Esteron LV96) also investigated. total percent dermal calculated from mean urinary...
Abstract The present study was undertaken to determine if the feeding of Lake Ontario salmon containing a mixture chemical contaminants, could produce toxicological response in rats. Male and female rats were fed freeze‐dried or Pacific Coho for 28 days at levels 1.45%, 2.90% 5.80% their normal diet. Body weight changes, organ weights, food intake, routine hematology, biochemical parameters, residue gross microscopic pathological changes determined. gain decreased all groups male but this...
Resection of gliomas in or close to motor areas is at high risk for morbidity and development surgery-related deficits. Navigated transcranial magnetic stimulation (nTMS) including nTMS-based tractography suitable presurgical planning assessment. The aim this study was investigate the association postoperative status spatial relation eloquent brain tissue order increase understanding Patient data, nTMS examinations imaging studies were retrospectively reviewed, corticospinal tracts (CST)...
Abstract Introduction: The pathogenesis of chronic subdural hematoma (CSDH) has not been completely understood. However, different mechanisms can result in space-occupying fluid collections, one pathway be the transformation an original trauma-induced acute (ASDH) into a CSDH. Materials and Methods: All patients with unilateral CSDH, requiring burr hole trephination between 2018 2023 were included. population was distributed acute-to-chronic group (group A, n = 41) conventional B, 282)....
As alterações renais representam uma das principais causas de óbito em felinos, o que está diretamente relacionado com diagnóstico tardio e dificuldade dos profissionais realizar condutas terapêuticas eficazes. O objetivo do presente relato foi descrever os métodos estadiamento tratamento empregados um caso doença renal crônica secundária a pielonefrite felino doméstico. Foi atendido clínica veterinária município Cruz Alta, Rio Grande Sul, sem raça definida, macho, quatro anos idade,...
The most beneficial treatment option for newly diagnosed glioblastoma is maximum safe resection and adjuvant therapy. Elderly patients carry a higher perioperative risk complications, thus, predictors of unfavorable surgical outcome must be evaluated more intensively. Consequently, we sought to evaluate surgery-related paradigms leading discontinuation after initial neurosurgical resection. Patients receiving microsurgical tumor CNS WHO grade 4 were evaluated. Further inclusion criteria was...
Navigated transcranial magnetic stimulation (nTMS) motor mapping has been established in the preoperative workflow of brain tumor patients. This study aimed to evaluate use postoperative nTMS mapping, which rarely performed surgery-associated corticospinal tract injuries and functional outcome. Patients undergoing resection tumors, who received pre- were retrospectively evaluated. Further inclusion criteria deterioration function or presence a deficit MRC ≤3/5 without significant improvement...
For the 5-year period 1991 to 1995, 1536 vegetable and 802 fruit samples were analyzed. The purpose of this study was determine if pesticides present on Ontario-produced fruits vegetables, so, residues violated maximum residue limits (MRLs). Overall, 31.5% had no detectable pesticide residues, whereas 68.5% contained one or more residues. Most at very low concentrations; 48% detections < 0.1 parts per million (ppm), 86% 1 ppm. However, violations MRL observed in only 3.2% vegetables 3.1%...
The dermal absorption of 14C‐ring‐labeled DEET (N,N‐diethyl‐m‐toluamide) applied in acetone to the skin Sprague‐Dawley rats and rhesus monkeys for 24 h was determined. Absorption dosed middorsally 36 ± 8% with a urinary excretion half‐life (t 1/2) 20 h. Both extent rate were highly dependent on anatomic site, 14 5% 1/2 = 4 h) penetrating forearm, 33 11% 6 forehead, 27 3% 7 dorsal forepaw, 68 9% 8 ventral forepaw. Since is commonly frequently by same individual, effect multiple exposure...
Uncertainty factors are used in the development of drinking-water guidelines to account for uncertainties database, including extrapolations toxicity from animal studies and variability within humans, which result some uncertainty about risk. The application is entrenched toxicological risk assessment worldwide, but not applied consistently. This report, prepared collaboration with Health Canada, provides an derivation factor assumptions developing quality chemical contaminants. Assumptions...
Navigated transcranial magnetic stimulation (nTMS) has been established as a preoperative diagnostic procedure in glioma surgery, increasing the extent of resection and preserving functional outcome. nTMS motor mapping for eloquent meningiomas not evaluated comparative analysis, yet.
Background: Non-invasive brain mapping using navigated transcranial magnetic stimulation (nTMS) is a valuable tool prior to resection of malignant tumors. With nTMS motor mapping, it additionally possible analyze the function system and evaluate tumor-induced neuroplasticity. Distinct changes in cortex excitability induced by certain tumors are focal point research. Methods: A retrospective single-center study was conducted involving patients with Clinical data, resting threshold (rMT),...
The in vitro persistence of 14C‐ring‐labeled fenitrothion acetone (F‐A) or N,N‐diethyl‐m‐toluamide (DEET) (F‐D) vehicles was determined, and vivo studies were conducted to determine the absorption [14C]fenitrothion DEET applied skin rats rhesus monkeys. In significantly enhanced vehicle, percent residual 14C activity at 24 h positively correlated with amount (micrograms) employed (e.g., vitro, 98.6 ± 7.7% recovery after versus 1.9 0.3% without DEET). Significantly greater (p < 0.05) detected...
The dimethylamine salt of 14 C‐ring‐labeled 2,4‐D was administered to Fischer 344 rats orally (1 and 0.4 mg/kg body weight) dermally (10 weight). Absorption, distribution, elimination were determined from C‐labeled in blood, tissues, excreta. Quantitatively, most the dose (94–96%) became systemically available within 6 h. Following dermal administration 10% over 72 However, peak concentrations blood kidneys achieved 30 min dosing by either route. By 1.5 h after dosing, muscle, liver, had...
Abstract Lake Ontario coho salmon were known to contain a mixture of chemical contaminants. A previous study demonstrated that rats fed the fish‐supplemented diet for 28 days exhibited mild biochemical and histological changes. The purpose present was determine effects due longer term exposure reversibility these effects. Growth rate food consumption not affected by feeding animals with or Pacific diets 13 weeks. No deaths observed. Decreased spleen weights observed in groups males 1.45%,...