A5103094743- Antibiotic Resistance in Bacteria
- Salmonella and Campylobacter epidemiology
- Bacteriophages and microbial interactions
- Escherichia coli research studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Genetic Mapping and Diversity in Plants and Animals
- Listeria monocytogenes in Food Safety
- Enterobacteriaceae and Cronobacter Research
- Genetics and Plant Breeding
- Viral gastroenteritis research and epidemiology
- Vibrio bacteria research studies
- Bacterial Genetics and Biotechnology
- Wheat and Barley Genetics and Pathology
- Essential Oils and Antimicrobial Activity
- Food Safety and Hygiene
- Crop Yield and Soil Fertility
- Clostridium difficile and Clostridium perfringens research
- Antibiotics Pharmacokinetics and Efficacy
- Plant Disease Resistance and Genetics
- Toxin Mechanisms and Immunotoxins
- Molecular Biology Techniques and Applications
- Plant Virus Research Studies
- Healthcare and Venom Research
- Helicobacter pylori-related gastroenterology studies
- Cell death mechanisms and regulation
China National Center for Food Safety Risk Assessment
2016-2025
Xinqiao Hospital
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2025
Hebei Agricultural University
2025
Second Affiliated Hospital of Xi'an Jiaotong University
2024
First Affiliated Hospital of Zhengzhou University
2024
Wuhan University of Science and Technology
2024
Zhongnan University of Economics and Law
2024
First Hospital of Jilin University
2024
Jilin University
2024
Abstract Objectives To report a novel tigecycline resistance gene, tet(X6), and its variants in four bacterial species isolated from chickens pigs China. Methods WGS was conducted to identify the suspected genes tigecycline-resistant Myroides phaeus 18QD1AZ29W. Functional cloning, homology modelling molecular docking were performed compare function with other Tet(X) variants. Retrospective screening for tet(X6) 80 isolates our data collection, all genomic environments of tet(X6)-positive...
Background The harvest index for many crops can be improved through introduction of dwarf stature to increase lodging resistance, combined with early maturity. inbred line Shen5003 has been widely used in maize breeding China as a key donor the trait. Also, one major quantitative trait locus (QTL) controlling plant height identified bin 5.05–5.06, across several bi-parental populations. With progress publicly available genome sequence, objective this work was identify candidate genes that...
The prevalence of Salmonella from chicken and pig slaughterhouses in Henan, China antimicrobial susceptibility these isolates to antibiotics was determined. From 283 samples 240 collected, 128 70 were recovered with an isolation rate 45.2 29.2% respectively. predominant serovars S. enterica serovar Enteritidis, Hadar Indiana, while those Typhimurium, Derby Enteritidis. Resistance ciprofloxacin 8.6 10.0% for chickens pigs respectively, whereas resistance cefotaxime 5.5 8.6%, Multidrug...
ABSTRACT Salmonellosis is a major global foodborne infection, and strains that are resistant to great variety of antibiotics have become public health concern. The aim this study was identify genes conferring resistance fluoroquinolones extended-spectrum β-lactams in nontyphoidal Salmonella (NTS) from patients food-producing animals China. In total, 133 21 NTS isolates humans, respectively, exhibiting concurrent ciprofloxacin cefotaxime were cultured independently 2009 ∼2013. All the...
The plasmid-mediated high-level tigecycline resistance gene, tet(X4), was detected in seven Escherichia coli isolates from pork two Chinese provinces. Two belonged to the epidemic spreading sequence type ST101. Tet(X4) adjacent ISVsa3 and concurrent with floR all isolates. In addition IncFIB, replicon IncFII found be linked tet(X4). This report follows a recent detection of tet(X3)/(X4) E. animals humans China.
Tigecycline, the first member of glycylcycline class antibiotic, is often considered one effective antibiotics against multidrug-resistant (MDR) infections. However, emergence and wide distribution two novel plasmid-mediated tigecycline resistance genes, tet (X3) (X4), pose a great threat to clinical use tigecycline.
Colistin is one of the last-resort antibiotics for treating infections caused by multidrug-resistant (MDR) Gram-negative bacteria. However, mcr genes conferring resistance to colistin have been widely identified, which considered a global threat public health. Here, we investigated prevalence and characteristics mcr-harboring Escherichia coli strains isolated from humans, animals, foods in China PCR, antimicrobial susceptibility testing, conjugation experiments, molecular typing, genome...
The emergence of carbapenem-resistant hypervirulent
Abstract The emergence of XBB- and JN.1-lineages with remarkable immune evasion characteristics have led to rises in breakthrough infections within populations. In addition, the unfavorable impacts imprinting, stemming from continuous exposure antigens circulated viruses, been observed incline response against earlier lineages, thereby declining neutralization newly emerged Omicron subvariants. this, advancement next-generation vaccines COVID-19 targeting components new subvariants such as...
Citrobacter freundii is an infrequent but established cause of diarrhea in humans. However, little known its genetic diversity and potential for virulence. We analyzed 26 isolates, including 12 from human diarrheal patients, 2 fecal samples unknown status, animals, insects, other sources. Pulsed field gel electrophoresis using XbaI allowed us to divide the isolates into 20 pulse types, while multi-locus sequence typing 7 housekeeping genes 6 types (STs) with majority belonging 4 STs....
Present study characterized five Escherichia coli co-expressing ESBL and MCR-1 recovered from food, food-producing animals, companion animals in China. Antimicrobial susceptibility tests, conjugation experiments, plasmid typing were performed. Whole genome sequencing (WGS) was undertaken for all isolates using either PacBio RS II or Illumina HiSeq 2500 platforms. The cefotaxime colistin resistance encoded by blaCTX-M mcr-1 genes, respectively, transferable together separately strains....
Tigecycline was considered the last-line drug against serious infections caused by multidrug-resistant Gram-negative bacteria. However, plasmid-mediated tigecycline resistance gene tet (X) has been widely reported in different sources of Enterobacterales and Acinetobacter China.
Chlorine disinfectants have been widely used in the poultry supply chain but this exposure can also result development of bacterial tolerance to chlorine and is often linked antibiotic cross-resistance. The objectives study were investigate sodium hypochlorite (NaClO) Salmonella isolated from chains evaluate We collected 172 isolates farms, slaughter houses retail markets China during 2019-2020. found that S. Enteritidis, Kentucky, Typhimurium constituted > 80% our isolates. Overall, 68%...
Salmonella enterica serovar 4,[5],12:i:- (S. 4,[5],12:i:-) is a monophasic variant of Typhimurium that has emerged as global causing public health concern. To date, the epidemiology and genomic characterization this pathogen in China have not been well described. We investigated prevalence, antimicrobial resistance (AMR) phenotypes, population genomics sequence type 34 (ST34) S. among cases human salmonellosis Henan Province, China. A total 100 ST34 isolates were studied from 2008 to 2017...
Objective: The aim of this study was to investigate the cellular effects melittin on growth and apoptosis human hepatocellular carcinoma (HCC) cells provide molecular mechanism for potential application a recombinant adenovirus carrying gene(Ad-rAFP-Mel) in treatment liver cancer. Methods:Human HCC (BEL-7402) were infected with Ad-rAFPMel at different times. In vitro cell determined by MTT assay. Cellular evaluated quantitatively qualitatively phase-contrast microscopy,transmission electron...
The nucleotide sequences of five plasmids from one Klebsiella oxytoca isolate were determined using the PacBio RS II system. Plasmid analysis revealed that blaNDM-1 was carried on an IncX3 plasmid. blaIMP-4 and blaKPC-2 genes located IncN IncP-6 plasmids, respectively. Comparative sequence highlighted successful spread carbapenemase-harboring among different enterobacterial species. We report for first time, to our knowledge, coproducing NDM-1, KPC-2, IMP-4 carbapenemases a K. isolate.