A5021944445- Epilepsy research and treatment
- Amyotrophic Lateral Sclerosis Research
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects and Toxicity Studies
- Parkinson's Disease Mechanisms and Treatments
- Mitochondrial Function and Pathology
- Neurogenetic and Muscular Disorders Research
- Genetic Neurodegenerative Diseases
- Muscle Physiology and Disorders
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Drug Transport and Resistance Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Gut microbiota and health
- Nuclear Receptors and Signaling
- Endoplasmic Reticulum Stress and Disease
- Neurological disorders and treatments
- Memory and Neural Mechanisms
- Cannabis and Cannabinoid Research
- Neuroendocrine regulation and behavior
- Tryptophan and brain disorders
- Ion channel regulation and function
- Histone Deacetylase Inhibitors Research
- RNA Research and Splicing
- Neurological and metabolic disorders
Fondazione Santa Lucia
2021-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2025
University of Rome Tor Vergata
2023-2025
Magna Graecia University
2019-2021
Abstract We studied the effects of intestinal inflammation on pentylenetetrazole (PTZ)-induced seizures in mice and thereon some antiepileptic anti-inflammatory treatments to establish if a link may exist. The agents tested were: alpha-lactoalbumin (ALAC), whey protein rich tryptophan, effective animal models epilepsy colon/intestine inflammation, valproic acid (VPA), an drug this seizure model, mesalazine (MSZ) aminosalicylate treatment against ulcerative colitis sodium butyrate (NaB),...
Type 2 diabetes mellitus (T2DM) is a risk factor for cognitive impairment. Ranolazine, an anti-ischemic drug used in the treatment of angina pectoris, has been shown to possess hypoglycemic properties pre-clinical and clinical studies. The aim this study was evaluate effects ranolazine on glucose metabolism function T2DM model Wistar rats. Diabetes induced by high fat diet (HFD) streptozotocin (STZ). control group received normal caloric (NCD) sodium citrate buffer. Metformin, effective...
A large number of studies have highlighted the important role gut microbiota in pathophysiology neurological disorders, suggesting that its manipulation might serve as a treatment strategy. We hypothesized participates absence seizure development and maintenance WAG/Rij rat model tested this hypothesis by evaluating potential intestinal alterations model, well measuring impact using fecal transplantation (FMT).Initially, composition histology rats (a well-recognized genetic epilepsy) were...
Background and Purpose Amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the degeneration of upper lower motor neurons, progressive wasting paralysis voluntary muscles is currently incurable. Although considered to be pure neuron disease, increasing evidence indicates that sole protection neurons single targeted drug not sufficient improve pathological phenotype. We therefore evaluated therapeutic potential multi‐target used treatment coronary artery...
Background: Amyotrophic lateral sclerosis (ALS) is a fatal neuromuscular disease characterized by the degeneration of motor neurons that leads to muscle wasting and atrophy. Epidemiological experimental evidence suggests causal relationship between ALS physical activity (PA). However, impact PA on neuron loss sarcopenia still debated, probably because heterogeneity intensities proposed exercises. With this study, we aimed clarify effect intense endurance exercise onset progression in...
Amyotrophic Lateral Sclerosis (ALS) is considered the prototype of motor neuron disease, characterized by loss and muscle waste. A well-established pathogenic hallmark ALS mitochondrial failure, leading to bioenergetic deficits. So far, pharmacological interventions for disease have proven ineffective. Trimetazidine (TMZ) described as a metabolic modulator acting on different cellular pathways. Its efficacy in enhancing muscular cardiovascular performance has been widely described, although...
Abstract Background Peripheral immune cells critically contribute to the clinical‐pathological progression of neurodegenerative diseases and also represent a reliable frame for translational applications. However, data on progressive supranuclear palsy (PSP) are almost scarce in this regard. Objective Our goal is provide broad biological characterization peripheral selected PSP cohort. Methods Seventy‐one patients scored Rating Scale (PSPRS), 59 controls were enrolled. The blood cell count...
Neuromelanin (NM) is a dark pigment accumulating with age in human substantia nigra pars compacta (SNpc) dopamine (DA) neurons, conferring the look that inspired nigral area's name. Despite NM has long been associated Parkinson's disease (PD), as melanized neurons favorably degenerate during development, functions within SNpc DA are still mostly elusive. Here, by exploiting an NM-producing rat model generated viral vector-induced expression of Tyrosinase (hTyr), we inspected impact on...
The TAR-DNA binding protein (TDP43) is a nuclear whose cytoplasmic inclusions are hallmarks of Amyotrophic Lateral Sclerosis (ALS). Acute stress in cells causes TDP43 mobilization to the cytoplasm and its aggregation through different routes. Although acute elicits strong phenotype, far from recapitulating years-long process. We applied chronic protocols described human neuroblastoma cell line by combining solubility assays, thioflavin-based microscopy flow cytometry. This approach allowed...
The discovery of potential antiseizure drugs (ASDs) requires the use experimental models that can also provide a unique chance for identifying new effective molecules able to prevent and/or cure epilepsy. Most preclinical knowledge on epileptogenesis derives from studies performed post-insult are characterized by recognizable first insult, silent period lasting until onset seizure and chronic spontaneous recurrent seizures (SRSs). At odds, genetic models, in which insult remains be...
Cannabis plants contain more than a hundred cannabinoids of which we have only limited knowledge about their effects and exact mechanisms action.Cannabidiol (CBD) represents one the most studied; it was discovered at beginning last century while recently has attracted greater attention.CBD mechanism action is still unclear debated; in plant (-) enantiomer can be found seems that (+) able to bind cannabinoid receptors although evidence modulation endocannabinoid system exists.Furthermore,...