A5103286609- Liver Disease Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Alcohol Consumption and Health Effects
- Inflammatory Biomarkers in Disease Prognosis
- Drug Transport and Resistance Mechanisms
- Nutritional Studies and Diet
- GABA and Rice Research
- Parkinson's Disease Mechanisms and Treatments
- Liver Diseases and Immunity
- Amyotrophic Lateral Sclerosis Research
- Neurological diseases and metabolism
- Sphingolipid Metabolism and Signaling
- Neurological Complications and Syndromes
- Acute Ischemic Stroke Management
- Neurosurgical Procedures and Complications
- Heat shock proteins research
- Pharmacological Effects of Natural Compounds
- Natural product bioactivities and synthesis
- Natural Compounds in Disease Treatment
- Ginseng Biological Effects and Applications
- Diet and metabolism studies
- Spectroscopy and Chemometric Analyses
- Ocular Diseases and Behçet’s Syndrome
- Phytochemicals and Antioxidant Activities
- Nutrition, Genetics, and Disease
Guangxi Medicinal Botanical Garden
2022-2024
Zunyi Medical University
2023
Central Hospital of Zibo
2023
Chongqing Medical University
2022
Peking University
2020-2022
Nanjing Medical University
2021
Peking University Third Hospital
2020
Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease and information on burden of ALS in mainland China was limited. We aimed to estimate the prevalence incidence China.We used 2012-2016 data from China's Urban Employee Basic Medical Insurance Residence Insurance, covering approximately 0.43 billion individuals. cases were identified by primary diagnosis (International Classification Diseases code or text diagnosis) insurance database.The crude 2016 2.91 per 100 000...
Abstract Aims The monocyte to high‐density lipoprotein cholesterol ratio (MHR) has emerged as a novel inflammatory biomarker of atherosclerotic cardiovascular disease. However, it not yet been identified whether MHR can predict the long‐term prognosis ischemic stroke. We aimed investigate associations levels with clinical outcomes in patients stroke or transient attack (TIA) at 3 months and 1 year. Methods derived data from Third China National Stroke Registry (CNSR‐III). Enrolled were...
Cinnamon is one of the most popular spices worldwide, and volatile organic compounds (VOCs) are its main metabolic products. The misuse or mixing cinnamon on market quite serious. This study used gas chromatography-ion migration spectroscopy (GC-IMS) technology to analyze VOCs samples. measurement results showed that 66 were detected in cinnamon, with terpenes being component accounting for 45.45%, followed by aldehydes 21.21%. content esters was higher RG-01, RG-02, RG-04; alcohols RG-01;...
Background Drug metabolism genes are involved in the vivo metabolic processing of drugs. In previous research, we found that a high-fat diet affected transcript levels mouse hepatic responsible for drug metabolism. Aims Our research intends to discover dysregulated at transcriptome level nonalcoholic fatty liver disease (NAFLD). Methods We analyzed 35 human tissues obtained during laparoscopic cholecystectomy. Additionally, imported data from mice fed and two open-access Gene Expression...
Background and Aims The heat shock protein (Hsp) 90α is induced by stress regulates inflammation through multiple pathways. Elevated serum Hsp90α had been found in nonalcoholic steatohepatitis (NASH). Geranylgeranylacetone (GGA, also called teprenone) a terpenoid derivative. It was reported to induce Hsp alleviate insulin resistance. We aimed evaluate the as biomarker predicting metabolic-associated fatty liver disease (MAFLD) define therapeutic effects of geranylgeranylacetone for disease....
Few studies have assessed the role of individual plasma cholesterol levels in association between egg consumption and risk cardiovascular diseases. This research aims to simultaneously explore associations self-reported with metabolic markers these disease (CVD). Totally 4778 participants (3401 CVD cases subdivided into subtypes 1377 controls) aged 30-79 were selected based on China Kadoorie Biobank. Targeted nuclear magnetic resonance was used quantify 225 metabolites baseline samples....
BackgroundNon-alcoholic fatty liver disease (NAFLD) is a common disorder characterized by hepatic steatosis, inflammation and fibrosis. Ganfule (GFL), traditional Chinese medicine, has demonstrated therapeutic potential in the treatment of NAFLD but mechanisms involved are not fully understood.To evaluate biochemical GFL treating examining its effects on biological networks, key targets, histopathological changes clinical implications.MethodsChemical component screening, target prediction,...
Background: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease. The fruits of Illicium verum, which medicinal and edible resource, have been shown to anti-inflammatory properties. Methods: In this study, we investigated the effects I. verum extracts (IVEs) on human RA fibroblasts-like synoviocytes (RA-FLS) by using sensitive selective ultra-high-performance liquid chromatography with high-definition mass spectrometry (UPLC-HDMS) method. We subsequently analyzed...
Two new triterpenes, 3β, 7β-dihydroxyolean-12-en-11-one (1) and 3β-O-acetyl-7β-hydroxyolean-12-en-11-one (2), along with four known triterpenes 3β-hydroxyolean-12-en-11-one (3), β-amyrin (4), lup-20(29)-ene-1β, 3β-diol (5) 1β, 3β-dihydroxy-urs-9(11)-12-diene (6), were isolated from the stems leaves of Maytenus guangxiensis C. Y. Cheng et W. L. Sha. Their structures elucidated using 1D 2D NMR spectroscopy as well MS IR experiments. Compounds (3-6) M. for first time. 1-6 evaluated their...