A5103654898- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Machine Learning in Bioinformatics
- Cancer Research and Treatments
- Cancer-related Molecular Pathways
- Lung Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Heat shock proteins research
- Immunotherapy and Immune Responses
- Molecular Biology Techniques and Applications
- DNA Repair Mechanisms
- Immune cells in cancer
- Advanced Computational Techniques and Applications
- Genomics, phytochemicals, and oxidative stress
- Advanced Algorithms and Applications
- Telomeres, Telomerase, and Senescence
- Glycosylation and Glycoproteins Research
- Liver Disease Diagnosis and Treatment
- Glutathione Transferases and Polymorphisms
- RNA Interference and Gene Delivery
- Biopolymer Synthesis and Applications
- Cancer, Hypoxia, and Metabolism
- Cancer-related gene regulation
- Peptidase Inhibition and Analysis
- Cancer-related molecular mechanisms research
Tianjin University
2024
Sichuan University
2023-2024
Wenzhou University
2024
Swiss Federal Laboratories for Materials Science and Technology
2024
China Spallation Neutron Source
2024
Spallation Neutron Source
2024
University of Science and Technology Beijing
2024
Oak Ridge National Laboratory
2024
Nanjing Agricultural University
2024
Czech Academy of Sciences, Institute of Physics
2024
Ovarian cancer is the tumor with highest mortality among gynecological malignancies. Studies have confirmed that paclitaxel chemoresistance associated increased infiltration of tumor-associated macrophages (TAMs) in microenvironment. Colony-stimulating factor 1 (CSF-1) receptor (CSF-1R) plays a key role regulating number and differentiation certain solid tumors. There are few reports on effects targeted inhibition CSF-1R combination chemotherapy ovarian Here, we explored antitumor efficacy...
Background: Lung cancer is the leading cause of cancer-related deaths worldwide due mainly to late diagnosis and poor prognosis. Aberrant promoter methylation an important mechanism for silencing tumor suppressor genes during carcinogenesis a promising tool development molecular biomarkers. Methods: We evaluated p16, RASSF1A, FHIT status in peripheral blood DNA between 200 lung patients normal controls by using SYBR green-based quantitative methylation-specific PCR (qMSP). Results: There...
Abstract Background: Heat shock protein 70 (Hsp70) has been shown to act as a chaperone and be associated with variety of tumors. We investigated HSP70-1 G+190C, HSP70-2 A+1267G, HSP70-hom T+2437C polymorphisms assess whether genetic variation in HSP70 plays role the occurrence development lung cancer. Methods: A case-control study was conducted using 159 patients cancer 202 control subjects. Genomic DNA typed for polymerase chain reactions restriction fragment length polymorphism...
Apolipoprotein E (APOE) plays a major role in lipid metabolism and inflammation. However, the association between APOE gene polymorphisms serum triglyceride levels remains controversial. We tested effects of variants on their interactions with inflammatory marker C-reactive protein (CRP) Taiwanese population. Two single nucleotide (SNPs) rs429358 rs7412 were genotyped by TaqMan Assay using real time PCR 595 healthy subjects attending clinic for routine visits. After adjustment clinical...
The preferable antigen delivery profile accompanied by sufficient adjuvants favors vaccine efficiency. Mitochondria, which feature prokaryotic characteristics and contain various damage-associated molecular patterns (DAMPs), are easily taken up phagocytes simultaneously activate innate immunity. In the current study, we established a mitochondria engineering platform for generating antigen-enriched as cancer vaccine. Ovalbumin (OVA) tyrosinase-related protein 2 (TRP2) were used model...
To develop a computer-aided diagnostic scheme of the CT in diagnosis lung cancer based on artificial neural networks (ANN) to assist radiologists distinguishing malignant from benign pulmonary nodules. 117 images nodules (58 and 59 malignant) were analyzed. 21 radiological features each case carefully selected quantified by three experienced radiologists. The 5 clinical parameters used as ANN input data. result ANNt was compared with those logistic regression ROC curve analysis. accuracy...
Lung injury after asbestos exposure is associated with an oxidative stress that catalyzed by iron in the fiber matrix, complexed to surface, or both. We tested hypothesis cellular response includes transport and sequestration of this through (1) generation superoxide for ferrireduction, (2) up-regulation divalent metal transporter-1 (DMT1) intracellular Fe2+, (3) increased production ferritin where stored a catalytically less reactive state. BEAS-2B cells normal elevated Cu,Zn dismutase...
Objective Chronic respiratory inflammation has been associated with lung cancer. Tumor-associated macrophages (TAMs) play a critical role in the formation of microenvironment. We sought to characterize TAMs coal tar pitch extract (CTPE)-induced tumorigenic transformation human bronchial epithelial cells and underlying mechanisms. Methods The expression TAMs-specific CD68 cancer tissues paired adjacent from patients was determined using immunostaining. Co-culture (BEAS-2B) macrophage-like...
Objective To identify the significance of a support vector machine (SVM) model and decision tree (DT) for diagnosis lung cancer combined with detection fragile histidine triad (FHIT), RAS association domain family 1 (RASSF1A) cyclin-dependent kinase inhibitor 2A (p16) promoter methylation levels relative telomere length (RTL) white blood cells from peripheral DNA. Methods The p16, RASSF1A FHIT RTL in DNA 200 healthy individuals patients were analyzed by SYBR Green-based quantitative...
Human protection of telomeres 1 (POT1) gene is a single stranded telomere binding proteins with critical role in ensuring chromosome stability. There have been variants POT1 gene, and the polymorphisms were associated some diseases. Polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) traditional method to detect nucleotide (SNP), it can be used rs10250202. But restriction enzymes required for detection rs10250202 are expensive. So we designed novel PCR–RFLP assay...
Objective To study which classification model was most suitable for establishing a multi-tumor markers lung cancer prediction model, through established logistic regression decision trees and artificial neural network model. Methods RIA analysis, ELISA, spectrophotometry, high-performance liquid chromatography (HPLC) atomic absorption spectrometry were used to measure the serum CEA , CA125, gastrin, NSE, B2-MG, sIL-6 receptors, sialic acid, nitric oxide, Cu, Zn, Ca pseudo-urine nucleoside of...
Coal tar pitch is a confirmed human carcinogen and composed mainly of polycyclic aromatic hydrocarbons.
Background: We sought to evaluate the role of tumor associated macrophages (TAMs) on promotion coal tar pitch extract (CTPE)-induced tumorigenesis human bronchial epithelial cells (BEAS-2B) and metastasis in nude mice, related mechanisms. Materials Methods: BEAS-2B were first treated with 2.4 mg/mL CTPE for 72 hours. After removal CTPE, continuously cultured passaged using trypsin-EDTA. THP-1 used as macrophage-like cells. under different conditions (n=6/group) injected into back necks...