A5038787137- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Quantum Chromodynamics and Particle Interactions
- Particle Detector Development and Performance
- Photoreceptor and optogenetics research
- bioluminescence and chemiluminescence research
- Drug Transport and Resistance Mechanisms
- Neutrino Physics Research
- Nicotinic Acetylcholine Receptors Study
- Computational Drug Discovery Methods
- Dark Matter and Cosmic Phenomena
- Alzheimer's disease research and treatments
- Air Quality Monitoring and Forecasting
- Air Quality and Health Impacts
- Acute Ischemic Stroke Management
- Circular RNAs in diseases
- Computational Physics and Python Applications
- Glycosylation and Glycoproteins Research
- Histone Deacetylase Inhibitors Research
- Molecular Communication and Nanonetworks
- Neurological Disease Mechanisms and Treatments
- Climate Change and Health Impacts
- Carbohydrate Chemistry and Synthesis
- RNA Research and Splicing
- Natural product bioactivities and synthesis
Peking University
2015-2025
State Key Laboratory of Natural and Biomimetic Drugs
2024
Jilin University
2012-2018
Nankai University
2018
Union Hospital
2012-2018
Southeast University
2010
Current cancer treatments face significant challenges, including limited tumor specificity and drug resistance. Enzyme‐instructed supramolecular peptide assembly targeting lysosomes offers a promising strategy to address these issues; however, self‐assembling units that withstand lysosomal conditions are still scarce. In this study, we present versatile glycopeptide incorporating glucuronic acid glucose undergoes glucuronidase‐triggered self‐assembly form nanofibers, leading membrane...
Glycosaminoglycans (GAGs) are essential polysaccharides crucial for various cellular functions, such as cell proliferation, migration, and differentiation. However, their complex structure variability from natural sources pose challenges functional studies therapeutic applications. In this study, we engineered a glycopeptide that assembles into fibrils, emulating the attributes of GAGs. Utilizing cryo-EM, elucidated atomic designed fibril, which is composed three identical protofilaments...
Cancer stem cells (CSCs) have been reported to be involved in tumorigenesis, tumor recurrence, cancer invasion, metastasis, and drug-resistance. Therefore, the development of drug molecules targeting CSCs has become an attractive therapeutic approach. However, which can selectively ablate are extremely rare. To explore leading compounds CSCs, 52 analogues triterpenoic acids were synthesized this study, whose biological activities evaluated. On basis results tumorsphere assay, two 48 51,...
Bioluminescence is a remarkable natural process in which living organisms produce light via specific biochemical reactions. Among these organisms, Renilla luciferase, derived from the sea pansy reniformis, notable for its blue emission, making it an ideal candidate bioluminescent tagging. Our focus lies at RLuc8, variant with eight amino acid substitutions, recent research has shown that emitter, coelenteramide, can exist different protonation states, significantly influenced by proximal...
Bioluminescence is a remarkable natural process in which living organisms produce light via specific biochemical reactions. Among these organisms, Renilla luciferase (RLuc), derived from the sea pansy reniformis, notable for its blue emission, making it one of promising candidates bioluminescent tagging. Our study focuses on RLuc8, modified variant RLuc characterized by eight amino acid substitutions. Recent findings have illuminated that luminescent emitter, coelenteramide, capable existing...
Bioluminescence is a fascinating natural phenomenon, wherein organisms produce light through specific biochemical reactions. Among these organisms, Renilla luciferase (RLuc) derived from the sea pansy reniformis notable for its blue emission and has potential applications in bioluminescent tagging. Our study focuses on RLuc8, variant of RLuc with eight amino acid substitutions. Recent studies have shown that luminescent emitter coelenteramide can adopt multiple protonation states, which may...
Gelatinases matrix metalloproteinase-2 and metalloproteinase-9 have been shown to mediate claudin-5 occludin degradation, play an important regulatory role in blood-brain barrier permeability. This study established a rat model of 1.5-hour middle cerebral artery occlusion with reperfusion. Protein expression levels gradually decreased the early stage reperfusion, which corresponded increase gelatinolytic activity metalloproteinase-9. In addition, rats that received treatment...
A meta-analysis was performed to identify empirical data assessing the effects of a single nucleotide polymorphisms sortilin-related receptor on Alzheimer’s disease based 14 studies involving 37941 cases and 49727 control studies. The results show an increased risk between nucleoti de (rs641120, rs1010159) susceptibility in Asian populations, rs689021 associated with decreased Caucasians, rs641120 detected as both populations. Given these data, we provide crucial evidence manifest that...
Background: Exposure to ambient particulate air pollution contributes substantially the mortality and morbidity due cardiovascular diseases (CVD). Several hypothetical mechanisms have been proposed explain these associations, particularly oxidative stress. Malondialdehyde (MDA), 8-hydroxy-2′-deoxyguanosine (8-OHdG), Superoxide Dismutase (SOD) are typical biomarkers of stress frequently investigated. However, association between exposure matter (PM) has not well established. Objectives:...