A5048345665- Pharmacological Effects of Natural Compounds
- Chemical Synthesis and Analysis
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Asymmetric Synthesis and Catalysis
- Inflammasome and immune disorders
- Traditional Chinese Medicine Analysis
- Catalytic C–H Functionalization Methods
- Synthesis and Catalytic Reactions
- Biotin and Related Studies
- interferon and immune responses
- Sulfur-Based Synthesis Techniques
- Cyclopropane Reaction Mechanisms
- Marine Sponges and Natural Products
- Natural product bioactivities and synthesis
- Carbohydrate Chemistry and Synthesis
- Nephrotoxicity and Medicinal Plants
- Synthetic Organic Chemistry Methods
- Click Chemistry and Applications
- Peptidase Inhibition and Analysis
- Asymmetric Hydrogenation and Catalysis
- Traditional and Medicinal Uses of Annonaceae
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Protein Degradation and Inhibitors
- Traditional Chinese Medicine Studies
Chinese PLA General Hospital
2023-2025
Hubei University of Science and Technology
2020-2025
Hunan University
2024-2025
Hunan University of Traditional Chinese Medicine
2024-2025
Chinese People's Liberation Army
2022-2024
Hubei University
2024
Nankai University
2017-2020
State Key Laboratory of Medicinal Chemical Biology
2018-2020
Tianjin University
2017-2020
State Council of the People's Republic of China
2019
Marine-derived bisindoles exhibit structural diversity and exert anti-cancer influence through multiple mechanisms. Comprehensive research has shown that the development success rate of drugs derived from marine natural products is four times higher than other derivatives. Currently, there are 20 marine-derived used in clinical practice, with 11 them demonstrating anti-tumor effects. This article provides a thorough review recent advancements exploration involving 167 bisindole their Not...
Breast cancer is a prevalent malignancy affecting women globally, characterized by significant morbidity and mortality rates. Ecliptae Herba traditional herbal medicine commonly used in clinical practice, has recently been found to possess antitumor properties. In order explore the underlying material basis molecular mechanisms responsible for anti-breast effects of Herba, we network pharmacology experimental verification. UPLC-MS/MS was utilized identify compounds present Herba. The active...
Graphical Abstract GUP can effectively inhibit the activation of cGAS-STING pathway induced by multiple stimuli and reduce expression type I interferon pro-inflammatory cytokines. Meanwhile also has a good therapeutic effect on sepsis contributed to cecum ligation puncture.
Abstract Background 6-Methoxydihydrosanguinarine (6-MDS) has shown promising potential in fighting against a variety of malignancies. Yet, its anti‑lung adenocarcinoma (LUAD) effect and the underlying mechanism remain largely unexplored. This study sought to explore targets probable 6-MDS LUAD through network pharmacology experimental validation. Methods The proliferative activity human cell line A549 was evaluated by Cell Counting Kit-8 (CCK8) assay. related targets, were obtained from...
Abstract Background The cGAS-STING signaling pathway is an essential section of the natural immune system. In recent years, increasing number studies have shown a strong link between abnormal activation pathway, mediated by nucleic acid receptor cGAS, and development progression autoimmune diseases. Therefore, it important to identify effective compound specifically downregulate this for disease. Methods effect Glabridin (Glab) was investigated in BMDMs Peripheral blood mononuclear cell...
Abstract Pancreatic ductal adenocarcinoma (PDAC) remains a formidable challenge due to its late diagnosis and intrinsic treatment resistance, exacerbates by development from chronic inflammation cancer transition (ICT). Here, this investigation aims develop evaluate ABSi‐148, novel near‐infrared (NIR) agent targeting hypoxic carbonic anhydrase IX ( CA ), for potential applications in ICT imaging even PDAC treatment. ABSi‐148 is synthesized 4‐(2‐Aminoethyl) benzene sulfonamide (ABS),...
Cancer stem cells (CSCs) have been reported to be involved in tumorigenesis, tumor recurrence, cancer invasion, metastasis, and drug-resistance. Therefore, the development of drug molecules targeting CSCs has become an attractive therapeutic approach. However, which can selectively ablate are extremely rare. To explore leading compounds CSCs, 52 analogues triterpenoic acids were synthesized this study, whose biological activities evaluated. On basis results tumorsphere assay, two 48 51,...
A one-step catalytic and diastereoselective method for the synthesis of aziridines possessing multiple chiral substitutions by radical aminotrifluoromethylation alkenes has been developed first time.
The reductive amination of cyclohexanone with ammonia over Cu-Cr-a/γ-Al<sub>2</sub>O<sub>3</sub> was investigated. It found that a proper solvent high solubility and 4Å molecular sieves for the elimination generated water contributed to formation cyclohexylamine in premixing process. In addition, addition fixedbed reactor could obviously improve conversion cyclohexylamine. Finally, reaction conditions including temperature, hydrogen pressure charging rate premix were optimized....