A5100705023- Invertebrate Immune Response Mechanisms
- Aquaculture disease management and microbiota
- Insect symbiosis and bacterial influences
- RNA modifications and cancer
- Neurobiology and Insect Physiology Research
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Insect Resistance and Genetics
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- interferon and immune responses
- Genetics, Aging, and Longevity in Model Organisms
- Insect and Pesticide Research
- Liver Disease Diagnosis and Treatment
- Redox biology and oxidative stress
- CRISPR and Genetic Engineering
- Heat shock proteins research
- Physiological and biochemical adaptations
- Kruppel-like factors research
- Ubiquitin and proteasome pathways
- Chromosomal and Genetic Variations
- Viral Infectious Diseases and Gene Expression in Insects
- Circular RNAs in diseases
- Animal Genetics and Reproduction
- Osteoarthritis Treatment and Mechanisms
- Virology and Viral Diseases
Institute of Hydrobiology
2017-2025
Chinese Academy of Sciences
2010-2025
Yangzhou University
2019-2025
Jiangsu Province Hospital
2022-2025
University of California, Riverside
2025
Central South University
2017-2024
Shanghai University of Traditional Chinese Medicine
2020-2024
Shuguang Hospital
2020-2024
Nankai University
2018-2024
Nanjing University of Chinese Medicine
2022-2024
Bin Han and colleagues report the draft genome sequence of grass carp Ctenopharyngodon idellus, a major commercially farmed species freshwater fish. Analyses identify lineage-specific duplications that may have contributed to adaptation this vegetarian diet. The is an important fish, accounting for ∼16% global aquaculture, has Here we 0.9-Gb gynogenetic female adult 1.07-Gb wild male adult. Genome annotation identified 27,263 protein-coding gene models in genome. A total 114 scaffolds...
To investigate the regulatory effect and mechanism of Vitamin D receptor (VDR) on mitochondrial function in renal tubular epithelial cell under diabetic status.
We described a next generation sequencing (NGS)-based approach to identify sex-specific markers and subsequently determine whether species has male or female heterogamety. To test the accuracy of this technique, we examined snakehead (Channa argus), which is economically important freshwater fish in China. Males grow faster than females, there significant interest developing methods skew breeding towards all-males increase biomass yields. NGS was conducted on DNAs individual male, reads were...
Abstract Methamphetamine (MA) is a potent stimulant and notoriously addictive. Individuals respond to MA effects differently thus have varying susceptible risk of developing use disorder. Cumulative evidence has indicated that gut dysbiosis contributes behavioral response drug effects. However, the role microbiota in disorder remained elusive. Using an MA‐induced conditioned place preference (CPP) rat model, we administrated same dose rats, which then showed distinct preferences drug‐related...
Abstract Background This study aimed to explore the potential regulatory mechanisms of brain metastasis and identify novel underlying targets lung cancer with metastasis. Methods Exosomes were isolated from plasma patients or without low high metastatic cells, small RNA plasma-derived exosomes sequenced. Differentially expressed miRNAs (DE-miRNAs) identified. Human microvascular endothelial cells (HBMECs) transfected miR-550a-3-5p mimics inhibitors exosomes. Cell viability, migration,...
Abstract Ran GTPase activating protein 1 (RanGAP1) has been implicated in various diseases, but its role colorectal cancer (CRC) progression remains unclear. Using tumor tissues and public databases, we found that RanGAP1 was significantly upregulated CRC associated with poor prognosis of patients. N6-methyladenosine (m6A) to play an important higher expression RanGAP1. MeRIP-seq, RIP-qPCR, Luciferase reporter assays other related experiment elucidated the molecular mechanism underlying m6A...
Serine protease cascade-mediated melanization is an important innate immune response in insects and crustaceans, which involves the proteolytic activation of prophenoloxidase (PPO). In this study, we investigated role Aedes aegypti PPO3 antifungal defence. We expressed purified recombinant (rPPO3) Escherichia coli demonstrated that rPPO3 was activated by ethanol and, to a lesser extent, cetylpyridinium chloride. presence Cu2+ , exhibited enzyme activity. Immunoblot results revealed cleaved...
Parasitoid wasps depend on a variety of maternal virulence factors to ensure successful parasitism. Encapsulation response carried out by host hemocytes is one the major immune responses toward limiting endoparasitoid wasp offspring production. We found that VRF1, metalloprotease homolog venom protein identified from wasp, Microplitis mediator, could modulate egg encapsulation in its host, cotton bollworm, Helicoverpa armigera. Here, we show VRF1 proenzyme cleaved after parasitism, and...
Pancreatic cancer (PAAD) is one of the most malignant cancers and immune microenvironment has been proved to be involved in pathogenesis PAAD. m6A modification, related expression regulators, participates development multiple cancers. However, correlation between regulators was largely unknown And because small sample size pancreatic TCGA database, it not enough draw a convincing conclusion. In present study, we downloaded seven datasets with survival data removed batch effects among these...
Transmembrane protein 43 (TMEM43), a member of the transmembrane subfamily, plays critical role in initiation and development cancers. However, little is known concerning biological function molecular mechanisms TMEM43 pancreatic cancer. In this study, expression levels were analyzed cancer samples compared with control samples. The relationship disease-free survival (DFS) overall (OS) assessed patients. vitro vivo assays performed to explore Coimmunoprecipitation (co-IP) followed by mass...
Abstract The tumor suppressor gene SMARCA4, a critical component of the SWI/SNF chromatin remodeling complex, is frequently inactivated in various cancers, including clear cell renal carcinoma (ccRCC). Despite its significance, role SMARCA4 ccRCC development and potential therapeutic vulnerabilities have not been fully explored. Our research found that deficiency was associated with poor prognosis observed subset high-grade ccRCCs. Through functional assays, we determined suppression led to...
Abstract Ohmic heating thawing (OHT), as a novel technique, possesses distinct advantages and is currently garnering attention from researchers. We have investigated the effects of OHT on structure protein quality duck breast meat. Compared to conventional (CT) methods (water [WT], 20 ± 0.5°C; air [AT], 0.5°C), (10, 15, V/cm) has been shown enhance efficiency, reducing time by 28%–86% ( p < 0.05), lowering loss rates 2.55% resulting in milder oxidation with better preservation secondary...
Grass carp ( Ctenopharyngodon idellus ) is an important aquaculture species in China that affected by serious diseases, especially hemorrhagic disease caused grass reovirus (GCRV). have previously shown age-dependent susceptibility to GCRV, however, the mechanism which this occurs remains poorly understood. Therefore, we performed transcriptome and metabolome sequencing on five-month-old (FMO) three-year-old (TYO) identify potential mechanism. Viral challenge experiments showed FMO fish were...
Grass carp are an important farmed fish in China that infected by many pathogens, especially grass reovirus (GCRV). Notably, showed age-dependent susceptibility to GCRV; is, not older than one year were sensitive GCRV, while those over three years old resistant this virus. However, the underlying mechanism remains unclear. Herein, whole genome-wide DNA methylation and gene expression variations between susceptible five-month-old (FMO) three-year-old (TYO) investigated aiming uncover...
Female mosquitoes are vectors of many devastating human diseases because they require blood feeding to initiate reproduction. Thus, elucidation molecular mechanisms managing female mosquito reproduction is essential. Although the regulation gene expression during gonadotrophic cycle has been studied in detail, how this process controlled at chromatin level remains unclear. Chromatin must be accessible for transcription factors (TFs) governing expression. A specialized class TFs, called...