A5112210117- Childhood Cancer Survivors' Quality of Life
- Acute Myeloid Leukemia Research
- Family and Disability Support Research
- Parvovirus B19 Infection Studies
- Ethics and Legal Issues in Pediatric Healthcare
- Autoimmune and Inflammatory Disorders Research
- Acute Lymphoblastic Leukemia research
- Iron Metabolism and Disorders
- Hemoglobinopathies and Related Disorders
- Neuroblastoma Research and Treatments
- Renal cell carcinoma treatment
- Infective Endocarditis Diagnosis and Management
- Neutropenia and Cancer Infections
- Palliative Care and End-of-Life Issues
- Central Venous Catheters and Hemodialysis
- Pediatric Pain Management Techniques
- Child and Adolescent Health
- Histiocytic Disorders and Treatments
- Vascular Tumors and Angiosarcomas
- Oral health in cancer treatment
- Music Therapy and Health
- Gastrointestinal disorders and treatments
- Hemophilia Treatment and Research
- Adrenal and Paraganglionic Tumors
- Chemotherapy-induced cardiotoxicity and mitigation
KK Women's and Children's Hospital
2015-2025
Duke-NUS Medical School
2020
Palmetto Hematology Oncology
2017
Health Promotion Board
2016
National University Cancer Institute, Singapore
2012
National University of Singapore
2012
University of Malaya
2012
Subang Jaya Medical Centre
2012
National University Health System
2012
Boston Children's Hospital
2007-2011
To improve treatment outcome for childhood acute lymphoblastic leukemia (ALL), we designed the Malaysia-Singapore ALL 2003 study with stratification based on presenting clinical and genetic features minimal residual disease (MRD) levels measured by polymerase chain reaction targeting a single antigen-receptor gene rearrangement.Five hundred fifty-six patients received risk-adapted therapy modified Berlin-Frankfurt-Münster-ALL treatment. High-risk was defined MRD ≥ 1 × 10(-3) at week 12...
Assessing habitual food consumption is challenging in multi-ethnic cosmopolitan settings. We systematically developed a semi-quantitative frequency questionnaire (FFQ) population Singapore, using data from two 24-h dietary recalls nationally representative sample of 805 Singapore residents Chinese, Malay and Indian ethnicity aged 18–79 years. Key steps included combining reported items on into standardized groups, developing list for the FFQ, pilot testing different question formats,...
Abstract Primary hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder associated with autosomal recessive variants in genes required for perforin-mediated lymphocyte cytotoxicity. A rapid diagnosis crucial successful treatment. Although defective cytotoxic T (CTL) function causes pathogenesis, quantification of natural killer (NK)–cell exocytosis triggered by K562 target cells currently represents standard diagnostic procedure primary HLH. We have prospectively evaluated...
Introduction: The care of children with cancer creates emotional and financial hardships for their families. There is a lack information on the impact childhood family as whole in Singapore. Thus, we set out to assess well its psychosocial our local context. Materials Methods: All patients diagnosed treated at Departments Paediatrics, KK Women’s Children’s Hospital National University Hospital, Singapore were eligible this study. Families these completed 2 self-administered questionnaires:...
Children with hemophagocytic lymphohistiocytosis (HLH) are at an increased risk of critical illness. In this study, we described the clinical characteristics critically ill children HLH and identify factors associated poor outcomes. who were diagnosed emergent admission to Children's Intensive Care Unit (CICU) between January 1, 2000 October 31, 2015 included. The primary outcome was CICU mortality. Over 15-year period, there 14 patients 23 admissions. Median age diagnosis 8.2 years...
To investigate social, clinical, and disease-related factors associated with diagnostic delay.Two-hundred 9 solid tumor cases reported to the Singapore Childhood Cancer Registry at KK Hospital between 1997 2007 were reviewed retrospectively. The natural logarithms of total delay times correlated disease using univariate multivariate analysis. Subanalysis was performed for periods before after first healthcare contact, which defined as parental physician delay, respectively.Mean 11.6 weeks....
Hemophagocytic lymphohistiocytosis is a rare childhood disorder characterized by uncontrolled proliferation of benign lymphocytes and histiocytes in multiple organs. Neurological presentations central nervous system involvement are highly variable. The authors present case familial hemophagocytic an 8-month-old girl with isolated reactivation optic nerve involvement. She presented fever hepatosplenomegaly at 2 months age. Genetic studies confirmed lymphohistiocytosis. There were no clinical...
Assessment of cancer predisposition syndromes (CPS) in childhood tumours is challenging to paediatric oncologists due inconsistent recognizable clinical phenotypes and family histories, especially cohorts with unknown prevalence germline mutations. Screening checklists were developed facilitate CPS detection patients; however, their value have yet been validated. Our study aims assess the utility screening validated by genetic sequencing an Asian cohort tumours. We evaluated 102 patients...
Poor nutritional status in children with cancer can impact treatment outcomes and mortality. Nutrition screening is a simple yet effective approach to identify malnutrition risk for early intervention. We aim improve the identification of at high malnutrition, so that intervention rehabilitation commence these children. Our multidisciplinary team conducted root cause analysis concluded generic tool did not differentiate different types, stage intensity treatment. Hence, considered identified...
The aim of this study was to explore the benefits music therapy (MT) for children with cancer over course their treatment in an acute paediatric hospital setting Singapore. Twenty-five undergoing received MT sessions as part a multidisciplinary team rehabilitation intervention from March 2017 January 2020. A total 37 individualised goals were developed by therapist cohort. Goals scored via Goal Attainment Scale at 3-month intervals up 1 year. Descriptive statistics and correlation analysis...
To explore oral health-related knowledge, abilities, attitudes, practices, and barriers of pediatric oncology nurses at an Asian children's hospital.A cross-sectional study was conducted via a self-administered anonymized questionnaire. Data analyzed to summarize confidence, practice behaviors.All sixty-three responded. Fifteen participants had >80% the knowledge questions correct. Majority (97.3%) agreed on their roles in helping patients maintain health. However, 75.8% felt need for...
Aim: To conduct a retrospective case analysis of the clinical efficacy and adverse effects deferiprone in our population. Methods: All patients with transfusion‐dependent thalassaemia at KK Hospital who have been on were included study. Outcomes measured include change ferritin levels cardiac T2* values during therapy, incidence side effects. Results: Thirty‐three (47.1%) total cohort 70 deferiprone, out which 26 combination therapy desferrioxamine. Majority (76%) had stable iron load four...
Introduction: Genetic mutations have been identified in the pathogenesis of vascular anomalies. Due to overlaps genetic variants causing anomalies and cancer, we used a next-generation sequencing panel for genomic profiling childhood cancers detect somatic children with We aim review utility an oncology molecular diagnosis Methods: Nine patients histologically confirmed were included. DNA was extracted from formalin-fixed paraffin-embedded tissue specimens obtained affected following...
Background: Anthracyclines are widely used to treat childhood cancers; however, they cause cardiotoxicity. To address the paucity of clinical data from Asian populations, this study investigated epidemiology pediatric anthracycline-induced cardiotoxicity, during and after chemotherapy, in a multiethnic population. Procedure: This was single-center, retrospective analysis 458 anthracycline-treated oncology patients at KK Women's Children's Hospital, tertiary children's hospital Singapore 2005...
Background: Traditional health economic evaluations of antimicrobials currently underestimate their value to wider society. They can be supplemented by additional elements including insurance value, which captures the an antimicrobial in preventing or mitigating impacts adverse risk events. Despite being commonplace other sectors, constituents and approaches for estimating have not been investigated. Objectives: This study assessed a novel gram-negative from operational healthcare,...
A case of acute myelogenous leukemia terminating in megakaryocytic myelosis is reported. There was a severe, apparently neoplastic proliferation megakaryocytes so different from that seen granulocytic or myelofibrosis diagnosis warranted. The clinical and pathologic findings the are presented detail. literature this extremely rare hematologic disease reviewed, differentiation chronic malignant myelosclerosis discussed.
Wilms tumor demonstrates significant interethnic epidemiological, histological and outcome differences, is rare poorly studied among Asians. We compared the clinicopathological, loss of heterozygosity (LOH) profile survival outcomes Asian non‐Asian patients with tumor. Clinical charts slides from malignant renal tumors over a period 20 years were retrospectively reviewed. adapted genotyping assay to determine 1p36 16q21‐22 LOH in formalin‐fixed paraffin‐embedded (FFPE) specimens, these...
Abstract Ex vivo evaluation of personalized models can facilitate individualized treatment selection for patients, and advance the discovery novel therapeutic options. However, embryonal malignancies, representative primary cultures have been difficult to establish. We developed patient‐derived cell (PDCs) from chemo‐naïve post–treatment neuroblastoma tumors in a consistent efficient manner, characterized their vitro growth dynamics, histomorphology, gene expression, functional...
Expectant observation of small adrenal lesions has shown promising results in recent studies. We present our 15 years outcome managing infant neuroblastoma.All patients with neuroblastoma below the age 1 year treated at largest pediatric hospital Singapore between 1998 and 2012 were identified.Twenty-two included study. Six antenatally diagnosed. Nineteen (86%) had surgical resection tumor. Eight (36%) received chemotherapy as part their treatment. observed three which large tumors. Median...
Introduction: Treatment of acute lymphoblastic leukaemia (ALL) using intensive chemotherapy has resulted in high cure rates but also substantial morbidity. Infective complications represent a significant proportion treatment-related toxicity. The objective this study was to describe the microbiological aetiology and clinical outcome episodes chemotherapy-induced febrile neutropaenia cohort children treated for ALL at our institution. Materials Methods: Patients with were either HKSGALL93 or...
Langerhans Cell Histiocytosis is a rare disease featuring aberrant proliferation of dendritic cells that can infiltrate the bony skeleton. The authors report case six-year-old female presenting with torticollis. She was found to have extensive lytic LCH lesions in cranio-cervical junction, causing atlanto-axial rotatory subluxation. Decision made for non-surgical approach treat patient. placed Halo brace, and given concomitant chemotherapy. Post-treatment imaging demonstrated near-complete...