Activation of protein kinase C (PKC) by phorbol esters or diacylglycerol mimetics induces apoptosis in androgen-dependent prostate cancer cells, an effect that involves both the activation classic PKC alpha and novel delta isozymes (Fujii, T., García-Bermejo, M. L., Bernabó, J. Caamaño, J., Ohba, M., Kuroki, Li, Yuspa, S. H., Kazanietz, G. (2000) Biol. Chem. 275, 7574-7582 Garcia-Bermejo, Leskow, F. C., Fujii, Wang, Q., Blumberg, P. Han, K. Lee, Marquez, V. E., (2002) 277, 645-655). In...

This study aimed to identify dosiomic features that have a significant impact on biochemical failure (BCF) following low-dose rate (LDR) brachytherapy treatment using Iodine-125 seeds for prostate cancer and provide insights into LDR efficacy approach. Between January 2005 February 2015, 1,205 patients with localized underwent seed implantation without combined external irradiation. A total of 96 were selected this study, including 48 BCF BCF. The divided two cohorts: derivation validation....

Introduction This study aimed to evaluate the prognostic significance of preoperative positron emission tomography-computed tomography (PET-CT) in resectable colorectal cancer (CRC), specifically examining association between standardized uptake value max (SUVmax) and recurrence risk, stratified by pathological stage. Methods A retrospective analysis was conducted on 164 CRC patients who underwent PET-CT before curative resection. SUVmax values were assessed for their correlation with...

Abstract For cell-based medicine, to mimic in vivo cellular localization, various tissue engineering approaches have been studied obtain a desirable arrangement of cells on scaffold materials. We developed novel method cell manipulation called “cell transfer technology”, enabling the cultured onto materials, and controlling topology. Here we show that using this technique, two different types can be transferred surface as stable double layers or patterned arrangements. Various combinations...

Transforming growth factor beta 1 (TGF-beta1) induces alpha2(I) collagen gene (COL1A2) expression in mesangial cells through physical and functional cooperation of Smad proteins Sp1. A transcriptional coactivator, p300, is also suggested to play an important role TGF-beta1/Smad signal transduction. However, the p300 TGF-beta1/Smad-pathway-mediated activation COL1A2 still obscure.Endogenous its modulation by TGF-beta1 were evaluated Western blotting immunofluorescence. The interaction with...

This paper describes the development of extremely wideband and very low-loss RF SAW filters ladder type for future communication systems. Because its large electromechanical coupling factor SH-type SAWs, a Cu-grating/15degYX-LiNbO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> structure was employed as substrate. At first, four-stage filter designed fabricated, where width/length weighted dummy electrodes were used to suppress spurious...

We demonstrate a high average power approximately 4 ps output from phase conjugate laser system based on diode-side-pumped Nd:Gd(0.6)Y(0.4)VO(4) bounce amplifier. An of 16.2 W with peak 210 kW was achieved. A corresponding extraction efficiency 23% measured.

The high coherent, power 193-nm ArF lasers are useful for interference lithography and microprosessing applications. In order to achieve coherence lasers, we have been developing a 193 nm solid state laser the seeding laser. We used sum frequency mixing of fourth harmonic (FH) 904-nm Ti:sapphire with Nd:YVO₄ (1342 nm) generate light. system consists single-mode oscillator seeded by external cavity diode, Pockels cell, 6-pass amplifier, 4-pass 2-pass amplifier wavelength conversion...

We report the observation of crack formation in glass surfaces after high-power laser pulse irradiation. The damage irradiated region was caused by ablation and plasma formation, but cracks liquid drops also appeared outside over a distance many millimeters. These became clearly visible at 12 h or more irradiation surface both soda-lime borosilicate crown glass. In contrast, such delayed not observed fused silica It is considered that chemical interactions components with atmospheric water...

A high power, 6 kHz, single-mode Ti:sapphire laser operating at 904 nm has been developed to produce a 193 light source. The output power was above 10 W with bandwidth of 160 MHz. Hansch–Couillaud locking scheme successfully applied stabilize the frequency pulse laser. thermal lens in crystal having focal length down mm along strong astigmatism compensated by distributing load three amplifiers an even number passes, resulting nearly diffraction limited beam. This contributed generation 200 mW.

Fluorescence microscopy is a useful tool that allows students to learn the principles of fluorescence visually in chemical and biological fields. However, equipment has high purchase maintenance costs thus may not be available educational institutions or insufficiently funded laboratories. In this study, microscope stage with colored light-emitting diodes (LEDs) was designed enabled conversion traditional inverted into view reducing these costs. A 3D printer used produce 12 holes on back...

Conventional dispersion-slope compensation filters suffer from a fundamental tradeoff between the amount of and bandwidth. A novel multireflection device, composed two coupled cavity in parallel configuration is proposed that has an adjustable independent The device provides value -6.7 -35.7 ps/sup 3/ over bandwidth 3 nm. center wavelength 10-nm range.

Millimeter-wave sensor applications require antennas which can be easily designed for beams with various shapes. Microstrip comb-line antenna is one of the attractive candidates since feeding loss relatively low rather than a parallel feeding. In design required radiation pattern in plane perpendicular to line, flexibility when number line small. We propose technique extend line. Designs beam- tilting several angles are implemented and feasibility proposed confirmed by experiments this paper.

Ring-shaped crystallization was observed in ion-implanted amorphous silicon by using picosecond extremely high-power laser pulses. A poly-crystalline region is formed circularly around the laser-induced damage even at an oblique incidence. Additionally, ripple structures are concentrically, and spacing decreases with increasing distance from spot center. The results well understood a picture that caused explosively laser-driven shock.

The authors propose and demonstrate novel coupled two-cavity allpass filters realised entirely as thin-film structures for dispersion slope compensation of optical fibres. have centre wavelengths tunable over 15 nm. By cascading two such filters, the can be adjusted between –4.5 –12.0 ps3 a bandwidth 2.4 1.2 nm, respectively. A combination cascaded enables transmission 1.6 ps pulse trains at 1550 nm through 60 km dispersion-shifted fibre without waveform distortion.

A novel multi-reflection device composed of two coupled-cavity filters in a parallel configuration is reported. The provides adjustable dispersion slope between -0.9 and -16.5 ps/sup 3/ over bandwidth 3 nm.

Damage tests of optical windows have been performed under irradiation an all-solid-state 4ω Nd:YAG laser. In the case a fused silica window, transmitted UV power decreased by 13% with 1.8×108 pulses. On other hand, decrease in was less than 1.5% for CaF2 windows. By using highly purified crystal as stable output 600 mW obtained deviation within 1.8% up to 9×108

view Abstract Citations (31) References (9) Co-Reads Similar Papers Volume Content Graphics Metrics Export Citation NASA/ADS Observation of Enhanced Soft X-Ray Emission from the Vicinity North Polar Spur de Korte, P. A. J. ; Bleeker, M. Deerenberg, Tanaka, Y. Yamashita, K. soft X-ray emission vicinity has been found by rocket-borne detectors in energy range 0.15-1.2 keV. The location regions enhanced and observed photon fluxes are fair agreement with a recent experiment Bunner et al. which...

An ultracompact gain block with Bi 2 O 3 -based erbium-doped fiber (Bi-EDF) is presented. The includes two pump LDs, isolators, a photodiode, dichromatic mirrors and Bi-EDF 23 cm long in the amplifier package size of only 45×43×10 mm. We can obtain net 25 dB output power 10 dBm at 1560 nm C-band region.

The authors propose a new method for quantitatively identifying the full charging point and degree of deterioration lead-acid batteries, which are used power storage equipment electric vehicles. Discharge according to hour rate can be also identified. theory this is recognize behavior active materials generated on surfaces electrodes by means applying rectangular positive (charging)/negative (discharging) current pulses battery. Thus degrees judged ascending/descending inclinations battery's...

Water embrittlement in ADI has been studied experimentally for several loading conditions. The phenomenon explained on the basis of a hypothesis hydrogen embrittlement. In addition to conventional tensile specimens, hole-edged CT specimens that can be used measure bending load were used. It was found latter more susceptible water than former, at maximum load. Some pre-strained dry conditions before testing wet Specimens had values beyond non-prestrained rupture point exhibited very similar...

Since aluminum and its alloys possess many excellent properties, such as light weight, high thermal electrical conductivity, corrosion resistance, specific strength so on, they have been widely used in various fields. In order to make the most of them future, it should be indispensable develop a new joining technology for them.With aid ultrasonic vibration, soldering method was proposed investigated this study. Commercial pure attempted soldered air using zinc filler metal. The effects...

Some ductile cast irons were up-quenched into an Al bath to refine the structure, and tested at temperatures near their eutectoid transformations determine whether superplasticity phenomenon occurs in these materials. Superplasticity was indicated by high strain rate sensitivity of flow stress ferrite+austenite+carbon region for M 10 (1%Mn content) austenite+carbon M15 (1.5%Mn content). The not constant M10 M15, but it decreased gradually value identical that M03 (0.3%Mn a higher rate....